Association of C-509T and T869C polymorphisms of transforming growth factor-b1 gene with susceptibility to and progression of IgA nephropathy

Lim, Chun Soo; Kim, Y S; Chae, Dong‐Wan; Ahn, Curie; Han, Jingjun; Kim, S; Lee, J S; Kim, I S

doi:10.5414/cnp63061

Cited by 24 publications

(25 citation statements)

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“…In addition, Vuong et al (2009) have reported an association between the TGF-β1 -C509T polymorphism and IgAN. Lim et al (2005) and Qin et al (2008) have found a similar association. Thus, the TGF-β1 -C509T susceptibility gene has an important role in the pathogenesis of IgAN.…”

Section: Introductionmentioning

confidence: 68%

“…Eight association studies relating to the TGF-β1 gene -C509T polymorphism with susceptibility to IgAN met the inclusion requirements for the meta-analysis (Carturan et al, 2004;Sato et al, 2004;Lim et al, 2005;Xue et al, 2005;Qin et al, 2008;Brezzi et al, 2009;Vuong et al, 2009;Li et al, 2011). A total of 1364 cases and 1483 controls were investigated.…”

Section: Subject Characteristicsmentioning

confidence: 99%

“…A total of 1364 cases and 1483 controls were investigated. Three studies were from China (Xue et al, 2005;Qin et al, 2008;Li et al, 2011), 2 from Italy (Carturan et al, 2004;Brezzi et al, 2009), 1 from Japan (Sato et al, 2004), 1 from Korea (Lim et al, 2005), and 1 from Sweden (Vuong et al, 2009). All cases of IgAN were diagnosed using World Health Organization diagnosis criteria.…”

Section: Subject Characteristicsmentioning

confidence: 99%

“…Thus, the TGF-β1 -C509T susceptibility gene has an important role in the pathogenesis of IgAN. Despite the association between TGF-β1 -C509T and IgAN observed in some Swedish, South Korea, and Chinese populations (Lim et al, 2005;Vuong et al, 2009;Li et al, 2011), the results of later studies are inconsistent (Carturan et al, 2004;Sato et al, 2004;Xue et al, 2005;Qin et al, 2008;Brezzi et al, 2009). Considering the possible small effect size of this genetic polymorphism in IgAN and the relatively small sample size in each study, discrepancies are likely to become apparent because a single study may have been underpowered for the detection of a small but real association.…”

Section: Introductionmentioning

confidence: 99%

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Meta-analysis demonstrates association of the TGF-β1 gene -C509T polymorphism with susceptibility to IgA nephropathy in European but not in Asian populations

Wang

Li²,

Feng³

2013

Genet. Mol. Res.

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ABSTRACT. There are conflicting reports associating the TGF-β1 gene -C509T polymorphism with susceptibility to IgA nephropathy. We investigated this association through a meta-analysis. Case-control studies were searched up to January 2012; the genotype frequencies in the control group were found to be consistent with Hardy-Weinberg equilibrium. Publication bias was tested by funnel plot and the Egger regression test. Eight studies, comprising 1364 cases and 1483 controls, were included. Significant heterogeneity was observed (χ 2 = 18.29, P = 0.01). Under the random-effects model, the overall odds ratio (OR) was 1.01 [95% confidence interval (95%CI) = 0.74-1.38; P = 0.94]. In the subgroup analysis based on ethnicities, no significant effect was observed in the Asian descent groups (five comparisons, OR = 0.78; 95%CI = 0.53-1.15; moderate heterogeneity between studies). However, an association was observed in the European descent groups (OR = 1.5; 95%CI = 1.15-1.96; P = 0.003; no significant heterogeneity between studies). There was no evidence of publication bias according to funnel plot and the Egger regression test (a = -2.16, P = 0.23). There was heterogeneity between studies and no clear evidence of an association between the TGF-β1 gene -C509T polymorphism and susceptibility to IgA nephropathy in the worldwide population. Subgroup analysis suggests that the TGF-β1 gene -C509T polymorphism would not be a risk factor for IgA nephropathy in Asians but might play a role in Europeans. More studies are required for definitive conclusions.

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Section: Introductionmentioning

confidence: 68%

Section: Subject Characteristicsmentioning

confidence: 99%

Section: Subject Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Meta-analysis demonstrates association of the TGF-β1 gene -C509T polymorphism with susceptibility to IgA nephropathy in European but not in Asian populations

Wang

Li²,

Feng³

2013

Genet. Mol. Res.

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“…The gene polymorphism can affect the activation of target gene, and the gene sites of T869C, C509T, and G915C were the important mutation points of TGF-b1. Some epidemiologic studies [10][11][12][13][14] investigating the association of TGF-1 T869C, C509T, G915C gene polymorphism with the risk of IgAN were conducted in the past decades. This meta-analysis was conducted to investigate whether the TGF-1 T869C, C509T, G915C gene polymorphism was associated with the risk of IgAN, by widely collecting the reported studies.…”

Section: Introductionmentioning

confidence: 99%

Association ofT869, C509T, G915Cgene polymorphism of transforming growth factor-β1 with IgA nephropathy risk

Zhou¹,

Guo²,

Yin

2014

Renal Failure

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This meta-analysis was conducted to assess the association of transforming growth factor-b1 (TGF-1) T869C, C509T, G915C gene polymorphism with the risk of IgA nephropathy (IgAN). The association literatures were identified from PubMed, Cochrane Library up to October 1, 2013, and eligible reports were recruited and synthesized. Five reports were recruited into this metaanalysis for the association of TGF-1 T869C, C509T, G915C gene polymorphism with IgAN risk. In this meta-analysis, the association of TGF-1 T869C, C509T, G915C gene polymorphism with IgAN risk was not found. In conclusion, TGF-1 T869C, C509T, G915C gene polymorphism is not associated with the IgAN risk. However, more studies should be performed in the future to confirm this association.

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Advances in Genetics of Immunoglobulin A Nephropathy

Zhang

Magistroni

Gharavi

2016

Pathogenesis and Treatment in IgA Nephropathy

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Association of C-509T and T869C polymorphisms of transforming growth factor-b1 gene with susceptibility to and progression of IgA nephropathy

Cited by 24 publications

References 0 publications

Meta-analysis demonstrates association of the TGF-β1 gene -C509T polymorphism with susceptibility to IgA nephropathy in European but not in Asian populations

Meta-analysis demonstrates association of the TGF-β1 gene -C509T polymorphism with susceptibility to IgA nephropathy in European but not in Asian populations

Association ofT869, C509T, G915Cgene polymorphism of transforming growth factor-β1 with IgA nephropathy risk

Advances in Genetics of Immunoglobulin A Nephropathy

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