Association ofT869, C509T, G915Cgene polymorphism of transforming growth factor-β1 with IgA nephropathy risk

Abstract

This meta-analysis was conducted to assess the association of transforming growth factor-b1 (TGF-1) T869C, C509T, G915C gene polymorphism with the risk of IgA nephropathy (IgAN). The association literatures were identified from PubMed, Cochrane Library up to October 1, 2013, and eligible reports were recruited and synthesized. Five reports were recruited into this metaanalysis for the association of TGF-1 T869C, C509T, G915C gene polymorphism with IgAN risk. In this meta-analysis, the association of TGF-1 T869C, C509T, G915C gene polymorphism with IgAN risk was not found. In conclusion, TGF-1 T869C, C509T, G915C gene polymorphism is not associated with the IgAN risk. However, more studies should be performed in the future to confirm this association.

Association of angiotensin II type-1 receptor A1166C gene polymorphism with the susceptibility of immunoglobulin A nephropathy

“…The pooled statistic was counted using the fixed effects model, but a random effects model was conducted when the p value of heterogeneity test was less than 0.1. [11][12][13] Results were expressed with odds ratios (OR) for dichotomous data, and 95% confidence intervals (CI) were also calculated. p50.05 Pei 1997 Asian 82 73 13 168 56 37 7 100 Maruyama 2001 Asian 75 20 0 95 80 19 0 99 Woo 2004 Asian 110 7 1 118 84 10 0 94 Huang 2010 Asian 113 17 0 130 100 20 0 120 was required for the overall OR to be deemed statistically significant.…”