Association of cardiac autonomic neuropathy with alteration of sympatho-vagal balance through heart rate variability analysis

Khandoker, Ahsan H.; Jelinek, Herbert F.; Moritani, Toshio; Palaniswami, Marimuthu

doi:10.1016/j.medengphy.2009.11.005

Cited by 59 publications

(64 citation statements)

References 37 publications

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“…The physiological interpretations of tone and entropy in various experimental settings were previously reported [5,15]. Lower tone values (negative) indicate that vagal activity predominates in the sympatho-vagal balance in a healthy population at rest [5,16,17].…”

Section: Discussionmentioning

confidence: 78%

“…Lower tone values (negative) indicate that vagal activity predominates in the sympatho-vagal balance in a healthy population at rest [5,16,17]. Higher tone (nearing zero or positive) and lower entropy values indicate that parasympathetic efferent pathways are progressively withdrawing their activity [15]. The main novelty of this work is to look at the tone and entropy values of fHRV at multiple lags with progress of gestational ages (early and late fetuses).…”

Section: Discussionmentioning

confidence: 99%

“…We suggest that the present results of increasing tone of the late foetus group is an alternate expression of this increased sympathetic activity and decreasing entropy as a reduction of HRV because entropy represents the total acceleration-inhibition activity of the cardiac autonomic nervous system function and outcome. Also, it was verified that tone was increased when HRV is significantly depressed after blockade of parasympathetic efferent pathways and the resulting dominance of the sympathetic division [15].…”

Section: Gradual Increase In Sympathetic Activity With Foetal Cardiovmentioning

confidence: 91%

“…This latter point makes it especially useful for clinical investigation where short time recordings are more likely to be taken [15]. In our previous study [15], the physiological implication of a T-E trace on a curvi-linear relation with a series of autonomic perturbations experiments was described. The T-E analysis results quantified parasympathetic nervous system activity during these perturbations as part of the sympatho-vagal control mechanism of heart function.…”

Section: Changes Of T-e Values At Different Lagsmentioning

confidence: 96%

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Tone Entropy Analysis of Foetal Heart Rate Variability

Khandoker

Karmakar

Kimura

et al. 2015

Entropy

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Development of the foetal autonomic nervous system can be indirectly understood by looking at the changes in beat to beat variability in foetal heart rates. This study presents Tone-Entropy (T-E) analysis of foetal heart rate variability (HRV) at multiple lags (1-8) to understand the influence of gestational ages (early and late) on the development of the foetal autonomic nervous system (ANS). The analysis was based on foetal electrocardiograms (FECGs) of 46 healthy foetuses of 20-32 weeks (early group) and 22 foetuses of 35-41 weeks (late group). Tone represents sympatho-vagal balance and entropy the total autonomic activities. Results show that tone increases and entropy decreases at all lags for the late foetus group. On the other hand, tone decreases and entropy increases at lags 1-4 in the early foetus group. Increasing tone in late foetuses might represent significant maturation of sympathetic nervous systems because foetuses approaching to delivery period need increased sympathetic activity. T-E could be quantitative clinical index to determine the early foetuses from late ones on the basis of maturation of autonomic nervous system.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Gradual Increase In Sympathetic Activity With Foetal Cardiovmentioning

confidence: 91%

Section: Changes Of T-e Values At Different Lagsmentioning

confidence: 96%

See 2 more Smart Citations

Tone Entropy Analysis of Foetal Heart Rate Variability

Khandoker

Karmakar

Kimura

et al. 2015

Entropy

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“…Reduced HRV is the earliest sign of CAN 2,[5][6][7][8] . Decline in HRV in T2DM was seen in several studies 3,[9][10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

Diabetic Cardiac Autonomic Dysfunction and Its Relationship with Duration of Diabetes

Phurpa¹,

Ferdousi

2016

J Bangladesh Soc Physiol

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Background: Duration of diabetes may have an important influence on cardiac autonomic dysfunction in type 2 diabetes mellitus.Objective: To assess the relationship of cardiac autonomic dysfunction in type 2 diabetes mellitus(T2DM) with the duration of diabetes.Methods: This crosssectional study was carried out from January to December 2015 on 54 long-term T2DM male patients aged 45 to 55 years, selected from the Endocrinology OPD of BSMMU, Dhaka. Thirty age matched recently diagnosed male T2DM patients(RT2DM) were control. Cardiac autonomic function was assessed by Heart Rate Variability(HRV). HRV measures were obtained by RMS multi channel polyrite-D. For statistical analysis, unpaired t-test and Pearsons correlation coefficient test were used.Results: Mean RR, SDNN, and HF nu were significantly lower (p < 0.001) whereas, mean HR, LF nu and LF/HF were significantly (p < 0.001) higher in LT2DM than those of RT2DM. SDNN, RMSSD and variance showed significant (p < 0.001) negative correlation with the duration of diabetes.Conclusions: Duration of diabetes had strong negative relationship with the diabetic cardiac autonomic dysfunction.Bangladesh Soc Physiol. 2016, June; 11(1): 1-5

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