Association of Cardiovascular Risk Factors and Coronary Artery Lesion Among Coronary Artery Disease Patients

Abstract

Background Coronary artery disease (CAD) is associated with the numbers of risk factors causing coronary atherosclerosis. Coronary artery stenosis is mostly caused by coronary atherosclerosis.Objective This study aims to analyze the association between coronary artery stenosis and cardiovascular risk factors.Methods An observational study was conducted among CAD patients. The diagnostic coronary angiogram was performed from femoral approach using standard catheters and techniques to find out any abnormalities.Result A total 73 patients (44 male and 29 female) with coronary artery disease undergoing diagnostic coronary angiography was included with the documented cardiovascular risk factors. The coronary stenosis was found in 40 patients on the basis of stenosis grading. Among the established cardiovascular risk factors, sex, diabetes mellitus and smokers show are significantly associated with coronary stenosis among CAD patients. The present study shows the significant association of coronary stenosis among male CAD patients (OR 2.47; CI 0.94 – 6.48, p <0.05) and similar association has been observed in diabetes mellitus (OR 3.32; CI 1.12 – 9.84, p <0.05) and smoking (OR 4.10; CI 1.45 – 11.61, p <0.01).Conclusion The prevalence of CAD is increased with numbers of presence of cardiovascular risk factors. Male gender, diabetes mellitus and smoking are significantly associated with coronary stenosis among CAD patients. However, hypertension and dyslipidemia are comparable between coronary stenosis and no significant stenosis group.Kathmandu University Medical Journal Vol.12(2) 2014: 137-140

Association of ESR1 (rs2234693 and rs9340799), CETP (rs708272), MTHFR (rs1801133 and rs2274976) and MS (rs185087) polymorphisms with Coronary Artery Disease (CAD)

“…The present study also depicts a significant difference between lipid levels and BMI in patients as compared to controls. These findings are in line with previous studies done by Iyer et al, [55], Raina et al, [56], Kalra et al, [57], Sekhri et al, [58], Koju et al, [59].…”

Association of smoking with coronary artery disease in Nepalese populations: a case control study

“…10,11 As Nepal is a resource poor country, if there is a continuous increase in disease burden by non-communicable disease such as CAD, Nepalese people cannot afford the costly curative services. 12 As in highincome countries, the major risk factors in the Nepalese population include tobacco use, alcohol consumption, unhealthy diet and physical inactivity, 13,14 which were recognized based on a prevalence study. Moreover, although it has policy on smoking reduction such as banning smoking in public places and writing the risk of smoking on the cover of a cigarette box, the obvious risk of CAD has still not been documented.…”

Dietary nutrients of relative importance associated with coronary artery disease: Public health implication from random forest analysis

“…Like in high-income countries, major traditional risk factors: tobacco use, alcohol consumption, unhealthy diet, and physical inactivity were reported in prevalence studies in the Nepalese population [22]. Although people's food habits vary with different ethnicities and geography, Nepalese commonly consume rice or bread, pulses, and vegetables, with potatoes prepared mostly in vegetable oil as the main meal.…”