Association of Cardiovascular Risk Factors With MRI Indices of Cerebrovascular Structure and Function and White Matter Hyperintensities in Young Adults

Williamson, Wilby; Lewandowski, Adam J.; Forkert, Nils D.; Griffanti, Ludovica; Okell, Thomas W.; Betts, Jill F.; Boardman, Henry; Siepmann, Timo; McKean, David; Huckstep, O J; Francis, Jane M; Neubauer, Stefan; Phellan, Renzo; Jenkinson, Mark; Doherty, Aiden; Dawes, Helen; Frangou, Eleni; Malamateniou, Christina; Foster, Charlie; Leeson, Paul

doi:10.1001/jama.2018.11498

Cited by 121 publications

(121 citation statements)

References 42 publications

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“…The neurodegeneration of AD-signature regions was measured by both MRI and [ 18 F] fluorodeoxyglucose (FDG) PET imaging. Cerebral white matter hyperintensities (WMHs) on MRI were used as a measure of cerebrovascular injury [33,34]. Additionally, we explored the associations between other categories of alcohol intake and the neuroimaging biomarkers mentioned above.…”

Section: Introductionmentioning

confidence: 99%

Association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: A cross-sectional study

Kim

Byun

et al. 2020

PLoS Med

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Background An emerging body of literature has indicated that moderate alcohol intake may be protective against Alzheimer disease (AD) dementia. However, little information is available regarding whether moderate alcohol intake is related to reductions in amyloid-beta (Aβ) deposition, or is protective via amyloid-independent mechanisms in the living human brain. Here we examined the associations of moderate alcohol intake with in vivo AD pathologies, including cerebral Aβ deposition, neurodegeneration of AD-signature regions, and cerebral white matter hyperintensities (WMHs) in the living human brain.

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Section: Introductionmentioning

confidence: 99%

Association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: A cross-sectional study

Kim

Byun

et al. 2020

PLoS Med

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“…Astrocytes and oligodendrocytes express store‐operated calcium entry (SOCE) channels TRPM3 and Orai/Stim, which are essential for glial Ca 2+ calcium signaling and play a role in the conduction, physiological, and pathological, such as in multiple sclerosis, stroke, and traumatic injury . A recent clinical study demonstrated that less white matter hyperintensities on MRI were closely related to a greater cerebral vascular density and diameter and a higher cerebral blood flow (Figures and ) …”

Section: The Organization and Function Of White Mattermentioning

confidence: 99%

“…24 A recent clinical study demonstrated that less white matter hyperintensities on MRI were closely related to a greater cerebral vascular density and diameter and a higher cerebral blood flow (Figures 1 and 2). 25…”

Section: The Org Aniz Ati On and Fun C Ti On Of White Mat Termentioning

confidence: 99%

White matter repair and treatment strategy after intracerebral hemorrhage

et al. 2019

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The predilection site of intracerebral hemorrhage (ICH) is in the basal ganglia, which is rich in white matter (WM) fiber bundles, such as cerebrospinal tract in the internal capsule. ICH induced damage to this area can easily lead to severe neurological dysfunction and affects the prognosis and quality of life of patients. At present, the pathophysiological mechanisms of white matter injury (WMI) after ICH have attracted researchers' attention, but studies on the repair and recovery mechanisms and therapy strategies remain rare. In this review, we mainly summarized the WM recovery and treatment strategies after ICH by updating the WMI‐related content by reviewing the latest researches and proposing the bottleneck of the current research.

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“…Cardiocerebral vascular diseases (CCVDs), including thrombosis, atherosclerosis, hypertension, cardiac hypertrophy, myocardial infarction, heart failure, stroke, and cerebral ischemia, are the major health problem all over the world, claiming more than 17.3 million lives annually [1][2][3]. Given the high incidence and high mortality of CCVDs, seeking feasible prevention and treatment strategy is highly imperative and critical to human health [4,5].…”

Section: Introductionmentioning

confidence: 99%

A Systems Pharmacology Approach for Identifying the Multiple Mechanisms of Action for the Rougui‐Fuzi Herb Pair in the Treatment of Cardiocerebral Vascular Diseases

Liu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Cardiocerebral vascular diseases (CCVDs) are the main reasons for high morbidity and mortality all over the world, including atherosclerosis, hypertension, myocardial infarction, stroke, and so on. Chinese herbs pair of the Cinnamomum cassia Presl (Chinese name, rougui) and the Aconitum carmichaelii Debx (Chinese name, fuzi) can be effective in CCVDs, which is recorded in the ancient classic book Shennong Bencao Jing, Mingyibielu and Thousand Golden Prescriptions. However, the active ingredients and the molecular mechanisms of rougui-fuzi in treatment of CCVDs are still unclear. This study was designed to apply a system pharmacology approach to reveal the molecular mechanisms of the rougui-fuzi anti-CCVDs. The 163 candidate compounds were retrieved from Traditional Chinese Medicine System Pharmacology Database and Analysis Platform (TCMSP). And 84 potential active compounds and the corresponding 42 targets were obtained from systematic model. The underlying mechanisms of the therapeutic effect for rougui-fuzi were investigated with gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Then, component-target-disease (C-T-D) and target-pathway (T-P) networks were constructed to further dissect the core pathways, potential targets, and active compounds in treatment of CCVDs for rougui-fuzi. We also constituted protein-protein in interaction (PPI) network by the reflect target protein of the crucial pathways against CCVDs. As a result, 21 key compounds, 8 key targets, and 3 key pathways were obtained for rougui-fuzi. Afterwards, molecular docking was performed to validate the reliability of the interactions between some compounds and their corresponding targets. Finally, UPLC-Q-Exactive-MSE and GC-MS/MS were analyzed to detect the active ingredients of rougui-fuzi. Our results may provide a new approach to clarify the molecular mechanisms of Chinese herb pair in treatment with CCVDs at a systematic level.

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Association of Cardiovascular Risk Factors With MRI Indices of Cerebrovascular Structure and Function and White Matter Hyperintensities in Young Adults

Cited by 121 publications

References 42 publications

Association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: A cross-sectional study

Association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: A cross-sectional study

White matter repair and treatment strategy after intracerebral hemorrhage

A Systems Pharmacology Approach for Identifying the Multiple Mechanisms of Action for the Rougui‐Fuzi Herb Pair in the Treatment of Cardiocerebral Vascular Diseases

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