Association of catechol‐O‐methyltransferase variants with loudness dependence of auditory evoked potentials

Abstract

These findings support the hypothesis that the LDAEP is also influenced by dopaminergic transmission. However, replications of these very preliminary but potentially important findings in independent samples are needed.

How Human Electrophysiology Informs Psychopharmacology: from Bottom-up Driven Processing to Top-Down Control

“…It has been suggested that the LDAEP is not only influenced by serotonin but also by dopaminergic neurotransmission (Juckel et al, 1997). Although the dopamine receptor agonists pergolide (D1/D2) and bromocriptine (D2) had no effect on the LDAEP, dopamine transporter availabilities correlate with LDAEP (Juckel et al, 2008), indicating that synaptic dopamine levels may modulate LDAEP. However, dopamine depletion did not modulate LDAEP .…”

Chronic modulation of serotonergic neurotransmission with sertraline attenuates the loudness dependence of the auditory evoked potential in healthy participants

“…This has included studies examining the acute effects of SSRIs in healthy participants (Uhl et al 2006;Guille et al 2008). Indeed, some studies have reported evidence indicating that the LDAEP is not only determined by serotonergic function, with both synaptic dopamine (DA) reuptake transporter availability (Pogarell et al 2004) and DA inactivation (via the COMT enzyme; Juckel et al 2008c), BDNF levels (Lang et al 2005) and N-methyl-D-aspartate (NMDA) receptors (O'Neill et al 2007) implicated. This raises the question of whether the LDAEP is a reliable indicator of serotonergic function in humans.…”

Psychophysiological Markers of Anxiety Disorders and Anxiety Symptoms

“…These studies provide evidence that the LDAEP is linked with the serotonin transporter polymorphism although there are inconsistencies in predicting directional changes in serotonin neurotransmission (O'Neill et al, 2008). There is evidence suggesting that the LDAEP is also modulated by dopaminergic neurotransmission (Juckel et al, 2008). High intensity dependence of auditory and visual evoked potentials were associated with low levels of dopamine metabolites (i.e., homvanillic acid) in cerebrospinal fluid and urine O'Neill et al, 2008).…”

“…Recently, Juckel and colleagues (2008) found that the LDAEP is also related with the genetic variants of the cCOMT-implicated in the inactivation of synaptic dopamine (Stein et al, 2005;Samochowiec et al, 2004). Reduced COMT activity caused by genetic polymorphisms was associated with a weaker LDAEP (Juckel et al, 2008). The LDAEP has been utilized to study dysfunctional serotonergic and dopaminergic activity in patients with GAD , PTSD (Park et al, 2010), schizophrenia or depression (Gallinat et al, 2000).…”