Association of CD14 −159 (−260C/T) polymorphism and asthma risk

Yang, Yang; Xu, Jin; Zhou, Zongke; Yu, Haiyang

doi:10.1097/md.0000000000004959

Cited by 6 publications

(10 citation statements)

References 52 publications

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“…Apart from other cells as T and B lymphocytes, eosinophils, basophils or neutrophils, monocytes are gaining importance as regulators of inflammation in asthma and as key players in the pathogenesis 34 – 36 . Our results show the expansion of this subset in AA regardless the severity of the symptoms (i.e., IMAA and MSAA), as well as a reduction of mCD14, a monocyte marker associated to asthma 3 . In contrast, some authors have described no differences in the staining for mCD14 37 , 38 , even though these could be the result of a low statistical sample size.…”

Section: Discussionmentioning

confidence: 52%

“…One of the most studied CD14 polymorphisms in asthma is the CD14 (−159 C/T) SNP (rs2569190) 11 . Previous studies investigating the association of this SNP with allergic asthma yielded variable results regarding to the strength and direction of association 3 , 17 , 24 . These contradictory results can be explained by differences in ethnicity, low sample size, age of patients or gene-environment interaction 21 , 25 .…”

Section: Discussionmentioning

confidence: 99%

“…Since those landmark studies, different works have confirmed these results 18 , 19 , while the C allele has been associated with high IgE levels, atopy and asthma 15 , 17 , 20 . However, this association has not been consistently replicated 3 , 13 , 21 – 24 . These different results may be attributed to a number of factors, like the low sample size, asthma phenotype (atopic, non-atopic or mixed asthma), age of study population (children or adults), ethnicity (African, Caucasian or Asiatic population) or gene-environment interactions (e.g., endotoxin levels) 21 , 25 .…”

Section: Introductionmentioning

confidence: 95%

“…Innate defences also rely on pattern recognition receptors, such as toll-like receptors (TLRs), capable of detecting pathogen-associated molecular patterns (PAMPs). Lipopolysaccharide (LPS) is a PAMP that interacts with CD14 (monocytes, macrophages, and neutrophils) 2 , a receptor whose gene has been linked to asthma/allergy 3 . CD14 transfers LPS to the TLR4-MD2 complex, which induces the secretion of a set of cytokines (IL-12/IL-18) that act as an innate-adaptive bridge and favour the TH 1 differentiation 4 .…”

Section: Introductionmentioning

confidence: 99%

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The CD14 (−159 C/T) SNP is associated with sCD14 levels and allergic asthma, but not with CD14 expression on monocytes

Nieto‐Fontarigo

Salgado

San-José

et al. 2018

Sci Rep

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LPS-ligation to CD14/TLR-4 on monocytes/macrophages triggers the production of IL-12-family cytokines. IL12/18 promote TH1-differentiation, counteracting the TH2-driven asthma. Therefore, CD14 modulation could alter the TH2-differentiation and should be taken into account when studying asthma. To analyse the alteration in CD14 levels and its association with CD14 (−159 C/T) SNP (rs2569190) in Caucasian adults with stable allergic asthma, we performed a cross-sectional study (277 healthy subjects vs. 277 patients) where clinical parameters, CD14 values and the CD14 (−159 C/T) SNP were studied. Apart from typical biomarkers, we found an increment of neuron-specific enolase (NSE) in allergic asthma, probably linked to monocyte activity. Indeed, we evidenced increased monocyte numbers, but lower CD14 expression and normalised sCD14 values in patients. Moreover, we noticed an association of the T allele (P = 0.0162) and TT genotype (P = 0.0196) of the CD14 SNP with a decreased risk of allergic asthma and augmented sCD14 levels. In conclusion, monocyte CD14 expression and normalized sCD14 values were reduced in stable state asthmatics, and this could be related to the presence of an expanded CD14low monocyte subset. This study also demonstrates that the CD14 (−159 C/T) polymorphism is a risk factor for moderate-severe allergic asthma in adult Caucasians.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The CD14 (−159 C/T) SNP is associated with sCD14 levels and allergic asthma, but not with CD14 expression on monocytes

Nieto‐Fontarigo

Salgado

San-José

et al. 2018

Sci Rep

View full text Add to dashboard Cite

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“…The quality of included eligible studies regarding the role of serum leptin levels in BC was assessed based on Newcastle–Ottawa Scale (NOS), which included the selection, the comparability of the groups, and the ascertainment of the exposure or outcome of interest with use of a “-” rating system. [11,25,26] The total scores ranged 0 to 9. A study with scores of ≥7 points was viewed as a high-quality study (Table 2).…”

Section: Methodsmentioning

confidence: 99%

Association of serum leptin with breast cancer

Wang

Cao³

et al. 2019

Medicine

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Background: Accumulating evidence has demonstrated that leptin is associated to the tumorigenesis and progression of breast cancer (BC). However, these studies remain inconsistent. Thus, a meta-analysis was conducted to investigate the role of leptin in the patients with BC. Method: A systematic search in PubMed, Embase, ISI Web of Science, and Chinese National Knowledge Infrastructure (CNKI) databases was conducted up to September 1, 2017. The standardized mean difference (SMD) with 95% confidence interval (CI) was applied to pool the effect size. A funnel plot and Egger test were used to evaluate publication bias. Results: Finally, 43 eligible studies were included in the current meta-analysis. Overall, serum leptin levels in BC cases were significantly higher compared with the controls (SMD = 0.61, P <.0001). When subgroup analyses were restricted to ethnicity and menstrual status, higher serum leptin concentration was also detected in patients with BC. Moreover, BC cases with body mass index (BMI) >25 indicated significantly higher serum leptin levels (SMD = 1.48, P = .034). Furthermore, the BC cases with lymph node metastases showed significantly higher serum leptin concentration (SMD = 0.53, P = .015). Conclusion: The present meta-analysis suggests that the serum leptin may profiles as a pivotal role in the pathogenesis and metastasis of BC. In addition, leptin will provide useful information for a therapeutic target to treat BC.

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The state of studying the polymorphism of individual genes in the development of bronchial asthma

Banadyha

2024

MPU

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The study of the polymorphism of individual genes is the basis of both preventive medicine and is used in the selection of adequate therapy. Polymorphism of individual candidate genes in bronchial asthma (BA) is studied taking into account many personal characteristics and the influence of environmental factors. Aim - to analyze the status of the study of the role of polymorphism of β2-adrenoceptors (ADRβ2) in the pathogenesis of bronchial asthma in children and to compare them with our own findings. Materials and methods. The results of research on polymorphism of individual genes in children with BA, which includes the PubMed database, were analyzed. An in-depth study of the anamnesis data (disease, life, hereditary), a complex clinical and laboratory examination of children (n=101) of school age with BA was carried out (the average age was: for boys 11.15±0.48 years; for girls - 10.63±0.7 years). Patients were diagnosed with BA in accordance with the GINA recommendations of the current revision. Determination of the Arg16Gly polymorphism of the ADRβ2 gene (rs 1042713) was performed by the polymerase chain reaction method followed by restriction enzyme analysis. The obtained data were processed in the Statsoft STATISTICA software package. Mean values were given as (M±m), Student's test was used for comparison. Results. The assessment of the frequency of polymorphism of the Arg16Gly gene in BA established that two variants prevailed in boys: Arg16Gly and Gly16Gly; at that time, the Gly16Gly genotype prevailed among girls, which, according to individual studies, is associated with good effectiveness of the applied therapy (nebulization of salbutamol). Mutations in the ADRβ2 gene in patients with BA were twice as frequent in the Arg16Gly genotype and three times as frequent in the Gln27Glu genotype, in contrast to healthy children. Such a polymorphism affects the functional activity of ADRβ2, the occurrence and course of BA. Conclusions. The Arg16Gly polymorphism of the ADRβ2 gene in children with BA largely determines the sensitivity of ADRβ2 to the applied exacerbation therapy and the effectiveness of basic treatment. In patients with the Gly16Gly genotype, most researchers note the good clinical effectiveness of both fast broncholytic drugs (β2 short-acting agonists) and basic anti-inflammatory drugs. The diagnosed homozygous Arg16Arg genotype of the ADRβ2 gene mostly accompanies the uncontrolled (or partially controlled) course of asthma in children. The revealed features of the Arg16Gly polymorphism of the ADRβ2 gene will help the doctor to draw up an adequate treatment plan, which is based on the genetically determined sensitivity of ADRβ2 receptors to medical preparations. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the author.

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Association of CD14 −159 (−260C/T) polymorphism and asthma risk

Cited by 6 publications

References 52 publications

The CD14 (−159 C/T) SNP is associated with sCD14 levels and allergic asthma, but not with CD14 expression on monocytes

The CD14 (−159 C/T) SNP is associated with sCD14 levels and allergic asthma, but not with CD14 expression on monocytes

Association of serum leptin with breast cancer

The state of studying the polymorphism of individual genes in the development of bronchial asthma

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