Association of cervical spine signs and symptoms with temporomandibular disorders in adults

Balthazard, Pierre; Hasler, Véronique; Goldman, Daniel S; Grondin, Francis

doi:10.11124/jbisrir-d-19-00107

Cited by 7 publications

(7 citation statements)

References 22 publications

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“…The prevalence of TMD is increasing and has become the second most important musculoskeletal disorder affecting the quality of life [ 12 ]. Along with inflammatory progression, the injured articular cartilage in TMD has limited capacity to heal.…”

Section: Discussionmentioning

confidence: 99%

Rapamycin-Induced Autophagy Promotes the Chondrogenic Differentiation of Synovium-Derived Mesenchymal Stem Cells in the Temporomandibular Joint in Response to IL-1β

Liu

Wang

et al. 2020

BioMed Research International

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Cartilage defects in temporomandibular disorders (TMD) lead to chronic pain and seldom heal. Synovium-derived mesenchymal stem cells (SMSCs) exhibit superior chondrogenesis and have become promising seed cells for cartilage tissue engineering. However, local inflammatory conditions that affect the repair of articular cartilage by SMSCs present a challenge, and the specific mechanism through which the function remains unclear. Thus, it is important to explore the chondrogenesis of SMSCs under inflammatory conditions of TMD such that they can be used more effectively in clinical treatment. In this study, we obtained SMSCs from TMD patients with severe cartilage injuries. In response to stimulation with IL-1β, which is well known as one of the most prevalent cytokines in TMD, MMP13 expression increased, while that of SOX9, aggrecan, and collagen II decreased during chondrogenic differentiation. At the same time, IL-1β upregulated the expression of mTOR and decreased the ratio of LC3-II/LC3-I and the formation of autophagosomes. Further study revealed that rapamycin pretreatment promoted the migration of SMSCs and the expression of chondrogenesis-related markers in the presence of IL-1β by inducing autophagy. 3-Benzyl-5-((2-nitrophenoxy)methyl)-dihydrofuran-2(3H)-one (3BDO), a new activator of mTOR, inhibited autophagy and increased the expression of p-GSK3βser9 and β-catenin, simulating the effect of IL-1β stimulation. Furthermore, rapamycin reduced the expression of mTOR, whereas the promotion of LC3-II/LC3-I was blocked by the GSK3β inhibitor TWS119. Taken together, these results indicate that rapamycin enhances the chondrogenesis of SMSCs by inducing autophagy, and GSK3β may be an important regulator in the process of rapamycin-induced autophagy. Thus, inducing autophagy may be a useful approach in the chondrogenic differentiation of SMSCs in the inflammatory microenvironment and may represent a novel TMD treatment.

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Section: Discussionmentioning

confidence: 99%

Rapamycin-Induced Autophagy Promotes the Chondrogenic Differentiation of Synovium-Derived Mesenchymal Stem Cells in the Temporomandibular Joint in Response to IL-1β

Liu

Wang

et al. 2020

BioMed Research International

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“…In the United States, TMD affect 5-12% of population. (Ahn et al, 2007;Balthazard et al, 2020) found that Myofascial release is effective in treating temporomandibular dysfunction previous study proved that Myofascial release in reduces pain, tenderness and improve function of temporomandibular joint. Fascia is located between the skin and the underlying structure of muscle and bone, it is a seamless web of connective tissue that covers and connects the muscles, organs and skeletal structures in our body.…”

Section: Introductionmentioning

confidence: 99%

“…Popping clicking and muscle tenderness is common condition that occurs at temporomandibular joint. Mechanically, the large amplitude of jaw opening or closing is associated with neck extension or lexion (Balthazard et al, 2020). It can be concluded that 90% of the patients with cervical pain were found to have temporomandibular disorders.…”

Section: Introductionmentioning

confidence: 99%

Comparison of two different techniques of mobilization in mechanical neck pain with decrease temporomandibular joint mobility

Iqbal¹,

Rishi²,

Sen³

2020

ijrps

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Pain in the anatomic region of neck is known as mechanical neck pain which is primarily caused by overuse of a normal anatomical structure, secondary to injury and deformity of anatomical structure. Also, mechanical neck pain can be defined as generalized neck pain provoked by sustained neck postures, neck movement, and pain on palpation of cervical musculature without pathologies. Restrictions of the neck movement occur and forced movement on the neck may worsen the pain. Mechanical neck pain is also known as nonspecific neck pain. It is a common complaint which affects 45-54% of the general population. The incidence of neck pain is higher in women (15%) than men (9%). High prevalence of neck pain was reported in desk job workers. 1-year prevalence of neck pain and work-related neck pain was reported as 43.3% and 28.3%. To compare the effect of Maitland and Mulligan mobilization with myofascial release on mechanical neck pain with decreased temporomandibular joint mobility. Total 45 subjects were selected and divided into three groups by random sampling method. This study concludes that Maitland mobilization and Mulligan mobilization are effective in mechanical neck pain with TMJ disability.

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“…The SCM is a biomechanical unit consisting of the mandible, skull, hyoid bone, supra-and infrahyoid muscles, and cervical spine, acting in an interconnected manner for stable functioning. Owing to this interrelationship, the presence of cervical changes can have an impact on the stomatognathic system and may affect the mandible and skull base, leading to TMD (Iunes, et al, 2009;Zieliński, et al, 2021;De Abreu, et al, 2021;Balthazard, et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of cervical alterations in patients with temporomandibular dysfunction in a specialized referral service

Silva

Cabral

2022

RSD

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The muscular structures of the body are interconnected, with the cervical and masticatory systems forming a part of the complex called Manducatory System, which is a part of the organic postural system. Alterations in one of these components induce compensatory changes and affect other systems. These adjustments can lead to temporomandibular dysfunction (TMD) and craniocervical dysfunction. Their etiology is multifactorial, with a high prevalence of chronic pain, especially in cases of headaches. Cervical alterations are common in TMD, considering the degree of pain and discomfort experienced by patients. This study aimed to conduct a survey of medical records regarding the frequency of TMD with cervical changes in patients who visited our institution between 2017 and 2019. Approximately 81.86% of patients showed cervical changes, and the sternocleidomastoid muscle showed the greatest involvement, especially in the mastoid portion. TMD showed greater involvement in women and was most prevalent between 40-49 years of age. This study contributes to scientific literature, since there are few reports highlighting the need to promote research and financial support in this subject area, which can help improve the diagnosis and treatment of these craniocervicomandibular disorders.

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Association of cervical spine signs and symptoms with temporomandibular disorders in adults

Cited by 7 publications

References 22 publications

Rapamycin-Induced Autophagy Promotes the Chondrogenic Differentiation of Synovium-Derived Mesenchymal Stem Cells in the Temporomandibular Joint in Response to IL-1β

Rapamycin-Induced Autophagy Promotes the Chondrogenic Differentiation of Synovium-Derived Mesenchymal Stem Cells in the Temporomandibular Joint in Response to IL-1β

Comparison of two different techniques of mobilization in mechanical neck pain with decrease temporomandibular joint mobility

Prevalence of cervical alterations in patients with temporomandibular dysfunction in a specialized referral service

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