Association of Chlamydia pneumoniae (Strain TWAR) Infection With Wheezing, Asthmatic Bronchitis, and Adult-Onset Asthma

Hahn, David L.

doi:10.1001/jama.1991.03470020051031

Cited by 438 publications

(172 citation statements)

References 26 publications

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“…Based on a prevalence of C. pneumoniae infection in acute bronchitis patients of between 5 % [13] and 25 % [21], this result was not surprising. Thus, use of a bronchitis control group would afford a more challenging test for association than the use of an asymptomatic control group.…”

Section: Resultsmentioning

confidence: 94%

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Association ofChlamydia pneumoniaeIgA antibodies with recently symptomatic asthma

Hahn

Anttila²,

Saikku

1996

Epidemiol. Infect.

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SUMMARYTo determine whether recently diagnosed adult-onset asthma is associated with serologic evidence of chronic Chlamydia pneumoniae infection, we performed a case-control study in a primary care clinic of cases with asthma (25 adults reporting first symptoms of asthma within 2 years of enrollment) and 45 concurrently enrolled sex and age (± 10 years) matched nonasthmatic controls with normal pulmonary function. C. pneumoniae-specific IgA, IgG and IgG4 antibodies, and circulating immune complexes (CIC) were measured by microimmunofluorescence testing. Results showed that frequencies of IgG titres > 16 (92%), IgG4 titres > 16 (20%) and CIC > 4 (60%) in asthma patients were not significantly different from those of controls. However, asthmatics had a significantly higher prevalence of C. pneumoniae-specific IgA titres > 10 (72 % of cases vs 44 % of controls, P < 0 05). After adjustment for the effects of age, sex and smoking, the odds ratio for an association of IgA and asthma was 3-7 (95 % confidence interval 1 2-11 5). We conclude that recently symptomatic reversible airway obstruction in adults is associated with the presence of C. pneumoniae-specific IgA antibodies, a proposed indicator of chronic respiratory C. pneumoniae infection.

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Section: Resultsmentioning

confidence: 94%

“…Diagnoses in the control group included visits for antibodies (IgG, IgA and IgM) [13]. The MIF test, when properly interpreted (not accepting non-specific bright fluorescence), is specific, and moreover, can differentiate immunoglobulin classes.…”

Section: Resultsmentioning

confidence: 99%

Association ofChlamydia pneumoniaeIgA antibodies with recently symptomatic asthma

Hahn

Anttila²,

Saikku

1996

Epidemiol. Infect.

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“…Most of the published information linking M. pneumoniae or C. pneumoniae infection to asthma is derived from studies in adult patients [6,7,11,12]. Few data are available regarding childhood [8,9].…”

mentioning

confidence: 99%

Importance of acute Mycoplasma pneumoniae and Chlamydia pneumoniae infections in children with wheezing

Esposito¹,

Blasi²,

Arosio³

et al. 2000

Eur Respir J

180

130

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In order to evaluate the role of Mycoplasma pneumoniae and Chlamydia pneumoniae in reactive airway disease, 71 children aged 2±14 yrs with an acute episode of wheezing and 80 age-matched healthy children were studied.Sera for the determination of specific antibody levels and nasopharyngeal aspirates for the detection of M. pneumoniae and C. pneumoniae deoxyribonucleic acid were obtained on admission and after 4±6 weeks. All children with wheezing received a standard therapy with inhaled corticosteroids and bronchodilators for 5±7 days; when antibiotic was added on the basis of the judgement of the paediatrician in charge, clarithromycin 15 mg . kg body weight -1 . day -1 for 10 days was used.Acute M. pneumoniae and C. pneumoniae infections were detected significantly more often in children with wheezing than in controls. In patients infected with one of the two pathogens, a history of recurrent wheezing was significantly more frequent than in those without either infection. During a 3-month follow-up period, among nonantibiotic-treated children, those with acute M. pneumoniae and/or C. pneumoniae infection showed a significantly higher recurrence of wheezing than those without acute M. pneumoniae and/or C. pneumoniae infection (p=0.03).These results highlight the apparently significant relationship of Mycoplasma pneumoniae and Chlamydia pneumoniae with wheezing in children, particularly in subjects with a history of recurrent episodes, and the possible improvement in the course of reactive airway disease within paediatric patients with acute Mycoplasma pneumoniae and/or Chlamydia pneumoniae infection.

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“…This bacterial species is a well-known cause of common human respiratory infection [2,3], with several studies also reporting that chronic chlamydial infection (persistent infection) can be an important clinical manifestation of persistent respiratory diseases such as asthma and atherosclerosis [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Effect of the steroid receptor antagonist RU486 (mifepristone) on an IFNγ-induced persistent Chlamydophila pneumoniae infection model in epithelial HEp-2 cells

Ishida

Yamazaki

Motohashi

et al. 2012

Journal of Infection and Chemotherapy

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Association of Chlamydia pneumoniae (Strain TWAR) Infection With Wheezing, Asthmatic Bronchitis, and Adult-Onset Asthma

Cited by 438 publications

References 26 publications

Association ofChlamydia pneumoniaeIgA antibodies with recently symptomatic asthma

Association ofChlamydia pneumoniaeIgA antibodies with recently symptomatic asthma

Importance of acute Mycoplasma pneumoniae and Chlamydia pneumoniae infections in children with wheezing

Effect of the steroid receptor antagonist RU486 (mifepristone) on an IFNγ-induced persistent Chlamydophila pneumoniae infection model in epithelial HEp-2 cells

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