Association of choline and betaine levels with cancer incidence and survival: A meta-analysis

Youn, Jiyoung; Cho, Eunyoung; Lee, Jung Eun

doi:10.1016/j.clnu.2018.01.042

Cited by 37 publications

(25 citation statements)

References 45 publications

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“…Multiple well-established ways aimed for curative treatment of HCC patients. However, the prognosis is still poor with five-year survival in the range of 5%-30% 1,2 . To improve long-term survival and diminish suffering of HCC patients, many convenient modifiable ways have been proposed to guide patient care, among which favorable dietary nutrients and nutritional status 3,4 still remain as major challenges.…”

Section: Introductionmentioning

confidence: 99%

“…Particularly, choline is a major source of methyl groups via oxidation to betaine, their functions involving the re-methylation of homocysteine to methionine are critical for DNA and histone methylation homeostasis, and therefore have been reported to be associated with cancer risk 2 (including liver cancer) and survival [7][8][9][10] . Experimental studies have reported that when deprived of choline, varying degrees of liver damages and liver diseases developed, including elevated transaminases 11 , affected lipid metabolism and transport 12 , fatty liver 13 , liver cirrhosis 13 and even liver cancer 14 , whereas choline or betaine supplementation ameliorated liver damage 15,16 , and choline supplementation increased global DNA methylation and DNA methyltransferase expression in HepG2 cells 17 , which implied that choline or betaine might not only be associated with hepatocarcinogenesis, but also with liver cancer survival.…”

Section: Introductionmentioning

confidence: 99%

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Serum choline is associated with hepatocellular carcinoma survival: a prospective cohort study

Liu¹,

Yishake²,

Fang³

et al. 2020

Preprint

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Background: Higher choline/betaine levels have been linked to lower risk of liver cancer, whereas existing data in relation to hepatocellular carcinoma (HCC) prognosis are scarce. Our objective was to examine the associations of the serum choline and betaine with HCC survival. Methods: 866 newly diagnosed HCC patients were enrolled in the Guangdong Liver Cancer Cohort. Serum choline and betaine were assessed using high-performance liquid chromatography with online electro-spray ionization tandem mass spectrometry. Liver cancer-specific survival (LCSS) and overall survival (OS) were calculated. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs). Results: Both LCSS (T3 vs. T1: HR=0.69, 95% CI: 0.51-0.94; P-trend <0.05) and OS (T3 vs. T1: HR=0.73, 95% CI: 0.54-0.99; P-trend <0.05) were better with sex-specific tertiles of serum choline levels. The associations were not significantly modified across strata of selected prognostic factors, except in the different C-reactive protein (CRP) levels, the favorable associations between serum choline and LCSS and OS were only existed among patients with CRP ≥3.0 mg/L. No significant associations were found between serum betaine levels and either LCSS or OS. Conclusions: This study revealed that higher serum choline levels were associated with better HCC survival, especially in HCC patients with systemic inflammation status. No significant associations were found between serum betaine and HCC survival. Our finding might open new prospect in understanding the benefits of choline on HCC survival. Registration: The Guangdong Liver Cancer Cohort was registered at clinicaltrials.gov as NCT 03297255.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum choline is associated with hepatocellular carcinoma survival: a prospective cohort study

Liu¹,

Yishake²,

Fang³

et al. 2020

Preprint

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“…Trimethylglycine (betaine) is a derivative of the amino acid glycine, a non-toxic natural substance; its physiological roles include osmoprotectant and methyl group donor activities. In addition, several reports found that Trimethylglycine has an anti-inflammatory effect on different diseases [10,11]. Particularly, in cancer it has been reported that Trimethylglycine intake may reduce the risk of nasopharyngeal carcinoma, breast, lung, liver, and colorectal cancer, highlighting a possible protective effect in the inhibition of tumor development [10,46], but the specific effect of its treatment has not yet been established.…”

Section: Discussionmentioning

confidence: 99%

“…In nasopharyngeal carcinoma, betaine intake was associated with a reduced risk of development of this neoplasia. In colorectal cancer metanalysis it was observed that high levels of Trimethylglycine were associated with a reduced risk of cancer incidence, suggesting that use of this osmoprotectant and anti-inflammatory agent may function as a preventive treatment in colon cancer [11]; however, experimental support is missing for this idea in both established and early stages of colon cancer development.…”

Section: Introductionmentioning

confidence: 99%

Use of STAT6 Phosphorylation Inhibitor and Trimethylglycine as New Adjuvant Therapies for 5-Fluorouracil in Colitis-Associated Tumorigenesis

Mendoza

Sánchez-Barrera

Callejas

et al. 2020

IJMS

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Colorectal cancer (CRC) is one of the most widespread and deadly types of neoplasia around the world, where the inflammatory microenvironment has critical importance in the process of tumor growth, metastasis, and drug resistance. Despite its limited effectiveness, 5-fluorouracil (5-FU) is the main drug utilized for CRC treatment. The combination of 5-FU with other agents modestly increases its effectiveness in patients. Here, we evaluated the anti-inflammatory Trimethylglycine and the Signal transducer and activator of transcription (STAT6) inhibitor AS1517499, as possible adjuvants to 5-FU in already established cancers, using a model of colitis-associated colon cancer (CAC). We found that these adjuvant therapies induced a remarkable reduction of tumor growth when administrated together with 5-FU, correlating with a reduction in STAT6-phosphorylation. This reduction upgraded the effect of 5-FU by increasing both levels of apoptosis and markers of cell adhesion such as E-cadherin, whereas decreased epithelial–mesenchymal transition markers were associated with aggressive phenotypes and drug resistance, such as β-catenin nuclear translocation and Zinc finger protein SNAI1 (SNAI1). Additionally, Il-10, Tgf-β, and Il-17a, critical pro-tumorigenic cytokines, were downmodulated in the colon by these adjuvant therapies. In vitro assays on human colon cancer cells showed that Trimethylglycine also reduced STAT6-phosphorylation. Our study is relatively unique in focusing on the effects of the combined administration of AS1517499 and Trimethylglycine together with 5-FU on already established CAC which synergizes to markedly reduce the colon tumor load. Together, these data point to STAT6 as a valuable target for adjuvant therapy in colon cancer.

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“…Кроме описания позитивных результатов влияния диетического бетаина на снижение сердечно-сосудистых заболеваний в литературе приводятся обнадеживающие данные о роли этого вещества: в защите от аллергии [34], уменьшении риска возникновения рака кишечника [40], продлении сроков выживаемости некоторых онкологических больных [13], предотвращении гиперлипидемии [19], снижении резистентности к инсулину [14].…”

Section: механизмы влияния биотина на уменьшение риска возникновения unclassified

Биологическая Роль И Польза Для Здоровья Бетаина В Зерновых Культурах (Обзор)

Полонский¹

2020

Bulletin of KSAU

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Цель исследования – анализ современной научной литературы по влиянию на здоровье человека бетаина, входящего в состав зерновых культур. К веществам, способствующим профилактике ряда серьезных заболеваний человека, относится бетаин, который содержится в зерновых культурах. Известно, что бетаин осуществляет несколько функций в организмах растений и животных, это осмолит, шаперон и донор метильной группы. Установлено, что суточная доза бетаина для большинства людей (в разных группах населения) составляет от 100 до 300 мг. Сегодня представляется весьма вероятным, что нарушения метаболизма бетаина вследствие повышения концентрации гомоцистеина в плазме крови являются фактором риска развития атеросклеротических заболеваний сосудов, а также появления тромбозов. Найдено, что алейроновые фракции зерна и пшеничные отруби способны выступать хорошим источником бетаина, оказывающим благоприятное физиологическое действие на человека. Показано более чем двукратное увеличение содержания бетаина в плазме крови после употребления как пшеничных отрубей, так и алейроновых фракций зерна по сравнению с исходным уровнем. Установлено, что бетаиновая терапия может предотвращать сосудистые события и иметь клинические преимущества в защите от аллергии, уменьшении риска возникновения некоторых форм рака, продлении сроков выживаемости онкологических больных, снижении резистентности к инсулину. Исходя из этого, бетаин сегодня используется в качестве ингредиента функционального питания и пищевой добавки. Хотя зерновые культуры считаются одним из основных компонентов питания человека, исследований содержания в них бетаина проведено недостаточно, а в Российской Федерации публикации по указанной теме практически отсутствуют. Обзор современной литературы предлагается с целью привлечения внимания генетиков, селекционеров, физиологов растений, биотехнологов и растениеводов к указанной проблеме.

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Association of choline and betaine levels with cancer incidence and survival: A meta-analysis

Cited by 37 publications

References 45 publications

Serum choline is associated with hepatocellular carcinoma survival: a prospective cohort study

Serum choline is associated with hepatocellular carcinoma survival: a prospective cohort study

Use of STAT6 Phosphorylation Inhibitor and Trimethylglycine as New Adjuvant Therapies for 5-Fluorouracil in Colitis-Associated Tumorigenesis

Биологическая Роль И Польза Для Здоровья Бетаина В Зерновых Культурах (Обзор)

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