Association of chromosome 8q24 variants with prostate cancer risk in the Siberian region of Russia and meta-analysis

Abstract

Compelling evidence demonstrates the importance of chromosome 8q24 as a locus of susceptibil ity to prostate cancer. In this work, the association of common 8q24 variants, rs6983267 and rs1447295, with a sporadic risk of prostate cancer was analyzed in the Russian population of Siberia. For this purpose, the above polymorphisms were genotyped in 393 cases and 384 control individuals. The A allele of rs1447295 was significantly associated with prostate cancer risk (OR[CI 95%] = 1.74 [1.26-2.4], p = 7.8 × 10 -4 ). The com mon G-A haplotype of rs6983267-rs1447295 also showed association with prostate cancer risk in Russians (OR[CI 95%] = 2.03 [1.1-3.75], p = 0.02). A meta analysis combining our data with previously published results was performed to better evaluate the association between the SNPs studied and prostate cancer risk; its results strongly supported the association for both loci (p < 10 -6 ). Thus, our study has confirmed the asso ciation of chromosome 8q24 with a risk of prostate cancer.

A duplex probe-directed recombinase amplification assay for detection of single nucleotide polymorphisms on 8q24 associated with prostate cancer

“…In 2006, Amundadottir et al found in Iceland, Sweden, and other populations that multiple SNPs in the chromosome 8q24 region are closely related to the risk of prostate cancer (PCa) by a large genome-wide association study (GWAS) (3). This correlation has been followed and confirmed in European Americans, African Americans and native Hawaiians, Spain, the Netherlands, Japan, and other peoples (4)(5)(6)(7)(8)(9)(10)(11). China has a few studies on the correlation between 8q24 region and PCa (12,13), but the results are not completely consistent.…”