Association of Chronic Periodontitis with Helicobacter pylori Infection in Stomach or Mouth: A Systematic Review and Meta-Analysis

Abstract

Helicobacter pylori (H. pylori) infection and periodontitis are both inflammatory conditions associated with systemic diseases. Researchers have attempted to investigate the correlation between them. This systematic review and meta-analyses were conducted to investigate the association of H. pylori infection in the stomach and/or in subgingival plaque and gingival crevicular fluid with chronic periodontitis. The protocol was created according to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) statement. The study was designed according to the Cochrane criteria. A comprehensive literature search was performed in MEDLINE, Scopus, and CENTRAL, combined with hand-searching and assessment of gray literature. The meta-analysis of the included studies was made by the Review Manager (RevMan) 5.4 software. The effect measure of the outcome was odds ratios with 95% confidence intervals. Heterogeneity was assessed by chi-square and I2. Four observational studies involving 818 subjects were included in this meta-analysis. The odds of oral H. pylori presence were higher in patients with chronic periodontitis, compared to healthy controls, with an odds ratio of 1.87 (95% confidence interval 0.85–4.10; p = 0.12). The odds of the presence of H. pylori in the stomach also were higher in patients with chronic periodontitis, with an odds ratio of 1.80 (95% confidence interval 0.82–3.95; p = 0.15). There is no evidence for an association between chronic periodontitis and the prevalence of H. pylori, detected either in subgingival plaque and gingival crevicular fluid or in the stomach.

Impact of CD34-dependent Micro Vessel Density on Periapical Odontogenic Cysts

“…Furthermore, chronic colon inflammation (colitis) leads indirectly to periodontitis by altering specific metabolic pathways (20). Additionally, Helicobacter pylori (H. pylori) stomach infection was suggested to be present in chronic periodontitis patients, CANCER DIAGNOSIS & PROGNOSIS 3: 189-193 (2023) but their exact relation is under investigation (21). In conjunction, apical periodontitis is the result of chronic endodontic inflammation mediated by bacteria of the Porphyromonas spp.…”

Programmed cell death of periodontal ligament cells

“…Helicobacter pylori is a Gram‐negative spiral bacterium that is commonly believed to be closely associated with the occurrence and development of gastritis and stomach ulcers. Patients with periodontitis may have a higher rate of H. pylori infection (Tsimpiris et al, 2022). Studies have shown that H. pylori arrests human periodontal ligament fibroblasts in the G2 phase of the cell cycle and promotes apoptosis (Li et al, 2019).…”