Association of cigarette smoking and CRP levels with DNA methylation in α-1 antitrypsin deficiency

Siedliński, Mateusz; Klanderman, Barbara J.; Sandhaus, Robert A.; Barker, Alan F.; Brantly, Mark; Eden, Edward; McElvaney, Noel G.; Rennard, Stephen I.; Stocks, James M.; Stoller, James K.; Strange, Charlie; Turino, Gerard M.; Campbell, Edward J.; DeMeo, Dawn L.

doi:10.4161/epi.20319

Cited by 24 publications

(15 citation statements)

References 21 publications

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“…Alanine aminotrans- 7 These results were in good agreement with results of a previous study. 9 Moreover, the prevalence of T2DM (16.9%), HTG (6.5%), and HP (52.9%) was lower in the centenarians than Chinese national levels (25.0%, 12.9%, and 66.9%, respectively).…”

Section: Assessment Of the Health Status Of Centenarians In The Southmentioning

confidence: 86%

Assessment of the Health Status of Centenarians in the South of China: A Cross‐Sectional Study

Zhang

Yang

et al. 2014

J American Geriatrics Society

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Section: Assessment Of the Health Status Of Centenarians In The Southmentioning

confidence: 86%

Assessment of the Health Status of Centenarians in the South of China: A Cross‐Sectional Study

Zhang

Yang

et al. 2014

J American Geriatrics Society

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“…Target genes were identified using a web-based gene network and functional annotation tool (genemania.org/) and review of prior human studies investigating the genetic and epigenetic control of inflammation (30,48,(67)(68)(69)(70) (additional details on target gene selection are provided in SI Materials and Methods). A total of 249 target genes were identified.…”

Section: Methodsmentioning

confidence: 99%

Social and physical environments early in development predict DNA methylation of inflammatory genes in young adulthood

McDade

Ryan

Jones

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

116

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Chronic inflammation contributes to a wide range of human diseases, and environments in infancy and childhood are important determinants of inflammatory phenotypes. The underlying biological mechanisms connecting early environments with the regulation of inflammation in adulthood are not known, but epigenetic processes are plausible candidates. We tested the hypothesis that patterns of DNA methylation (DNAm) in inflammatory genes in young adulthood would be predicted by early life nutritional, microbial, and psychosocial exposures previously associated with levels of inflammation. Data come from a population-based longitudinal birth cohort study in metropolitan Cebu, the Philippines, and DNAm was characterized in whole blood samples from 494 participants (age 20–22 y). Analyses focused on probes in 114 target genes involved in the regulation of inflammation, and we identified 10 sites across nine genes where the level of DNAm was significantly predicted by the following variables: household socioeconomic status in childhood, extended absence of a parent in childhood, exposure to animal feces in infancy, birth in the dry season, or duration of exclusive breastfeeding. To evaluate the biological significance of these sites, we tested for associations with a panel of inflammatory biomarkers measured in plasma obtained at the same age as DNAm assessment. Three sites predicted elevated inflammation, and one site predicted lower inflammation, consistent with the interpretation that levels of DNAm at these sites are functionally relevant. This pattern of results points toward DNAm as a potentially important biological mechanism through which developmental environments shape inflammatory phenotypes across the life course.

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“…Interestingly, DNA methylation induced by cigarette smoking affected α-1 anti-trypsin deficiency, which may be linked to the development of emphysema [85]. In this study, CpG methylation occurred mainly in genes that regulate signal transduction proteins inducible by TGF-β.…”

Section: Other Epigenetic Mechanisms That Affect Protein Translation mentioning

confidence: 54%

The Role of Mnk-1, Eukaryotic Translation Initiation Factors and Translation Control in the Pathogenesis of Asthma

Khan¹,

Roth²

2017

J Cell Signal

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Association of cigarette smoking and CRP levels with DNA methylation in α-1 antitrypsin deficiency

Abstract: Association of cigarette smoking and CRP levels with DNA methylation in α-1 antitrypsin deficiency, Epigenetics,7:7,[720][721][722][723][724][725][726][727][728]

Cited by 24 publications

References 21 publications

Assessment of the Health Status of Centenarians in the South of China: A Cross‐Sectional Study

Assessment of the Health Status of Centenarians in the South of China: A Cross‐Sectional Study

Social and physical environments early in development predict DNA methylation of inflammatory genes in young adulthood

The Role of Mnk-1, Eukaryotic Translation Initiation Factors and Translation Control in the Pathogenesis of Asthma

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