Association of Circulating Chemerin With Subclinical Parameters of Atherosclerosis

Zylla, Stephanie; Dörr, Marcus; Völzke, Henry; Schminke, Ulf; Felix, Stephan B.; Nauck, Matthias; Friedrich, Nele

doi:10.1161/atvbaha.118.311219

Cited by 21 publications

(23 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…BMI was the only variable that correlated with chemerin and there was no significant difference in the BMI between the two groups. Recently, several studies have reported that elevated circulating chemerin levels correlate with endothelial dysfunction and can be a biomarker of subclinical atherosclerosis (42)(43)(44). However, in our study, no such relationship between the chemerin levels, quantitative IMT, and arterial stiffness was observed.…”

Section: Discussioncontrasting

confidence: 87%

Association of Adipocytokines With Carotid Intima Media Thickness and Arterial Stiffness in Obstructive Sleep Apnea Patients

Song

et al. 2020

Front. Endocrinol.

View full text Add to dashboard Cite

Objective: Obstructive sleep apnea (OSA) results in increased carotid intima-media thickness (IMT) and arterial stiffness; however, the association between adipocytokines and IMT/arterial stiffness in OSA patients is unclear. Methods:We enrolled 95 normal weight and overweight, not obese, participants from May 2018 to December 2018 in this study. All subjects underwent a carotid artery ultrasound examination and polysomnography. Blood samples were used to determine serum chemerin, adiponectin, SFRP5, and apelin levels. Correlations between two quantitative variables were assessed using the Pearson or Spearman coefficient.Stepwise models of multiple linear regression analysis were performed to assess the independent relationships.Result: IMT in OSA patients was significantly higher than in the non-snorers. There were significant differences in the arterial stiffness parameters such as distensibility coefficient (DC), compliance coefficient (CC), and pulse wave velocity (PWV). SFRP5 level was lower in OSA patients than in non-snorers. Adiponectin correlated with CC, DC, and PWV among OSA patients; however, the relationship disappeared after a multivariable adjustment. Age was independently associated with all quantitative IMT and stiffness indices. AHI and minimum oxygen saturation (Mini SaO 2 ) were independently related to arterial stiffness. Conclusion:The quantitative IMT and carotid arterial elasticity were significantly worse among OSA patients. Age was the main independent factor correlated with quantitative IMT and arterial stiffness, and AHI and mini SaO 2 were associated factors. There were no relationships between aforementioned adipocytokines and quantitative IMT/carotid arterial stiffness.

show abstract

Section: Discussioncontrasting

confidence: 87%

Association of Adipocytokines With Carotid Intima Media Thickness and Arterial Stiffness in Obstructive Sleep Apnea Patients

Song

et al. 2020

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…Staining of plaques from ApoE−/− mice showed that chemerin increased the lipid content in the plaques and reduced the collagen content, thus increasing the possibility of plaque rupture. In a previous clinical study, chemerin levels were elevated in patients with coronary heart disease and were associated with the number of unstable plaques and the number of coronary lesions [24,38], and the results of this study are in accordance with those findings. In this study, all lipid parameters in ApoE−/− mice were significantly higher than those in WT mice, which is consistent with the genetic characteristics of the model animals.…”

Section: Discussionsupporting

confidence: 91%

“…Chemerin, which is considered an adipokine, was first identified in 2007. Recently, chemerin has been shown to be closely related to inflammation, metabolic syndrome and cardiovascular diseases [ 24 ]. Several studies have concluded that chemerin can be considered a marker of a high atherosclerotic risk [ 25 , 26 ]; however, the specific mechanism of chemerin in AS development has not yet been clarified.…”

Section: Discussionmentioning

confidence: 99%

Chemerin enhances the adhesion and migration of human endothelial progenitor cells and increases lipid accumulation in mice with atherosclerosis

et al. 2020

View full text Add to dashboard Cite

Background The role of adipokines in the development of atherosclerosis (AS) has received increasing attention in recent years. This study aimed to explore the effects of chemerin on the functions of human endothelial progenitor cells (EPCs) and to investigate its role in lipid accumulation in ApoE-knockout (ApoE−/−) mice. Methods EPCs were cultured and treated with chemerin together with the specific p38 mitogen-activated protein kinase (MAPK) inhibitor SB 203580 in a time- and dose-dependent manner. Changes in migration, adhesion, proliferation and the apoptosis rate of EPCs were detected. ApoE−/− mice with high-fat diet-induced AS were treated with chemerin with or without SB 203580. Weights were recorded, lipid indicators were detected, and tissues sections were stained. Results The data showed that chemerin enhanced the adhesion and migration abilities of EPCs, and reduced the apoptosis ratio and that this effect might be mediated through the p38 MAPK pathway. Additionally, chemerin increased the instability of plaques. Compared with the control group and the inhibitor group, ApoE−/− mice treated with chemerin protein had more serious arterial stenosis, higher lipid contents in plaques and decreased collagen. Lipid accumulation in the liver and kidney and inflammation in the hepatic portal area were enhanced by treatment with chemerin, and the size of adipocytes also increased after chemerin treatment. In conclusion, chemerin can enhance the adhesion and migration abilities of human EPCs and reduce the apoptosis ratio. In animals, chemerin can increase lipid accumulation in atherosclerotic plaques and exacerbate plaques instability. At the same time, chemerin can cause abnormal lipid accumulation in the livers and kidneys of model animals. After specifically blocking the p38 MAPK pathway, the effect of chemerin was reduced. Conclusions In conclusion, this study showed that chemerin enhances the adhesion and migration abilities of EPCs and increases the instability of plaques and abnormal lipid accumulation in ApoE−/− mice. Furthermore, these effects might be mediated through the p38 MAPK pathway.

show abstract

“…These suggest that chemerin is an adipokine whose secretion can be altered by exercise-induced adiposity reduction. Chemerin is generally elevated in T2DM patients 33,34 , especially in older T2DM patients 41 . Moreover, chemerin was suggested to be a better measure for insulin sensitivity than HOMA-IR in normoglycemic subjects 10 .…”

Section: Discussionmentioning

confidence: 99%

Semaphorin 3 C is a Novel Adipokine Representing Exercise-Induced Improvements of Metabolism in Metabolically Healthy Obese Young Males

Nam

Ahn

Park

et al. 2020

Sci Rep

View full text Add to dashboard Cite

This study investigated the endurance exercise-induced changes in lesser known adipokines (visfatin, chemerin, apelin, semaphorin 3 C) related to obesity and metabolism, and their correlations with the changes in the parameters of obesity and glucose homeostasis. Forty metabolically healthy obese young males were randomly assigned to control group (C, n = 12) or exercise group (Ex, n = 28). The subjects in Ex participated in a 8-week supervised endurance exercise training program, comprised of four sessions of treadmill running at 65-70% of VO 2max per week. Serum levels of visfatin, chemerin, apelin, and semaphorin 3 C were significantly decreased in Ex. At baseline, apelin and semaphorin 3 C appeared to be correlated with obesity measures, including body mass index, % total fat and trunk fat, and waist circumference. Exercise-induced changes in these obesity measures significantly correlated with the changes in chemerin and semaphorin 3 C. Basal chemerin, apelin and semaphorin 3 C correlated with glucose homeostasis parameters, including fasting plasma glucose, fasting plasma insulin, homeostasis model assessment of insulin resistance and β-cell function, and quantitative insulin-sensitivity check index to different extents. Furthermore, the changes in apelin and semaphorin 3 C well predicted the improvements in glycemic parameters. We suggest that semaphorin 3 C is a novel adipokine involved in pathophysiology of obesity and metabolism, and that it is a biomarker representing an exercise-induced improvement in metabolically healthy obese young males.

show abstract

Association of Circulating Chemerin With Subclinical Parameters of Atherosclerosis

Abstract: Supplemental Digital Content is available in the text.

Cited by 21 publications

References 54 publications

Association of Adipocytokines With Carotid Intima Media Thickness and Arterial Stiffness in Obstructive Sleep Apnea Patients

Association of Adipocytokines With Carotid Intima Media Thickness and Arterial Stiffness in Obstructive Sleep Apnea Patients

Chemerin enhances the adhesion and migration of human endothelial progenitor cells and increases lipid accumulation in mice with atherosclerosis

Semaphorin 3 C is a Novel Adipokine Representing Exercise-Induced Improvements of Metabolism in Metabolically Healthy Obese Young Males

Contact Info

Product

Resources

About