Association of circulating sTRAIL and high-sensitivity CRP with type 2 diabetic nephropathy and foot ulcers

Arik, Hasan Onur; Yalçın, Arzu Didem; Gümüşlü, Saadet; Genc, Gizem Esra; Turan, Adil; Şanlioğlu, Ahter Dilşad

doi:10.12659/msm.889514

Cited by 17 publications

(13 citation statements)

References 19 publications

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“…fasting serum glucose and glycated haemoglobin, were worse in T1D compared with T2D patients, but did not show significant variations in respect to the severity of DFS [18]. The results of this study clearly confirm previous reports that significantly higher levels of hs-CRP and neopterin were observed in T2D complicated with foot ulcers [19,21]. Higher serum levels of neopterin among T2D compared with T1D patients indicates activation of cell-mediated immune response and increase in reactive oxygen species [22,23].…”

Section: Discussionsupporting

confidence: 87%

Assessment of serum neopterin as an inflammatory and cardiovascular marker in type 1 and 2 diabetes complicated by diabetic foot syndrome: a comparative study

Al-Nimer¹,

Dezayee

2018

Clinical Diabetology

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Introduction. Neopterin is a byproduct of nerve transmitter coenzyme that is synthesized and released by macrophages and T-lymphocytes. It is a useful inflammatory marker of diabetes progression, as its levels increase with the progression of the disease from prediabetes to type 2 diabetes (T2D). This study aimed to compare serum neopterin levels between type-1 and type-2 diabetes patients with diabetic foot syndrome (DFS), and assess the relation between serum neopterin levels and cardiometabolic risk factors. Materials and methods. This observational cross-sectional study was carried out in the Centre of Diabetes Mellitus in Erbil, Iraq from 1 st January to 31 st December 2016. A total of 30 healthy subjects and 140 patients with DFS [70 patients with type 1 diabetes (T1D) and 70 patients with T2D] were enrolled in the study. The main outcome measurements included anthropometric measurements, blood pressure, fasting serum glucose, glycated haemoglobin, lipid profile, neopterin and high sensitivity C-reactive protein (hs-CRP). Results. Serum neopterin levels of T2D patients were significantly (p < 0.001) higher than the corresponding levels of T1D patients (18.6 ± 2.1 nmol/L vs. 12.6 ± 1.3 nmol/L). The changes in the serum neopterin levels were related to cardiometabolic risk factors. In T1D, a significant positive correlation between serum levels of neopterin and diastolic blood pressure were observed, while in T2D the significant positive correlation was found between fasting serum triglyceride levels and neopterin levels. Serum levels of neopterin were insignificantly correlated with hs-CRP in T1D and T2D. Conclusions. In patients with DFS, serum neopterin levels are significantly higher in those with T2D compared with T1D patients. Neopterin levels are not related to the grading of DFS, but are invariably related to cardiometabolic risk factors.

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Section: Discussionsupporting

confidence: 87%

Assessment of serum neopterin as an inflammatory and cardiovascular marker in type 1 and 2 diabetes complicated by diabetic foot syndrome: a comparative study

Al-Nimer¹,

Dezayee

2018

Clinical Diabetology

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“…We showed the pro-inflammatory effect of sOX-2 in our previous studies [12,13–17]. A patient of ours with TEN (toxic epidermal necrolysis) also had DM and had higher sOX-2 levels versus a healthy control group, despite TEN treatment [15].…”

Section: Introductionsupporting

confidence: 59%

Evaluation of soluble CD200 levels in type 2 diabetic foot and nephropathic patients: Association with disease activity

et al. 2014

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BackgroundCD200 (OX-2) is a novel immune-effective molecule, existing in a cell membrane-bound form, as well as in a soluble form in serum (s OX-2), which acts to regulate inflammatory and acquired immune responses.Material/MethodsWe planned this study to evaluate the sOX-2 levels of type 2 diabetic foot (group B), and compare it with that of healthy controls (group A). The patient group had the following values: DM period: 27.9±10.3 year [mean ±SD], HbA1c: 9.52±2.44% [mean ±SD].ResultsBlood samples for sCD200 measurement were always taken in the morning between 8 and 10 A.M.. The results were reported as means of duplicate measurements. Concentrations of sOX-2 in the serum samples were quantified using an ELISA kit. Serum hs-CRP levels were measured using an hs-CRP assay kit. The sOX-2 level in group B was 173.8±3.1 and in group A was 70.52±1.2 [p<0.0001). In subgroup analysis of T2DM-DFI patients, we noticed that sOX-2 levels were higher in WGS (Wagner grading system) I and II patients than in WGS III and IV patients. The HbA1c, BUN, creatinine, hs-CRP levels, and sedimentation rates were higher in the patient group (p<0.0001, p<0.001, p<0.001, p<0.005, and p<0.0001, respectively).ConclusionsWe suggest that there are vascular, immunologic, and neurologic components in DFI, whereas autoimmune diseases and inflammatory skin disorders have only an immunologic component. This is possibly evidence of a pro-inflammatory effect seen in DFI as a vascular complication.

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“…As a common characteristic pathological change of all types of diabetes, hyperglycemia can cause hyperinsulinemia and increase the risk of diabetic angiopathy. Under hyperglycemic condition, end-products of glycosylation and oxidative stress can activate glomerular endothelial cells, which produce adhesion molecules such as ICAM-1, further causing the adhesion, infiltration across vascular walls, and transformation of monocytes into macrophages [ 15 – 18 ]. Activated macrophages can produce large amounts of cytokines, including TNF-α, which facilitates glomerular sclerosis.…”

Section: Discussionmentioning

confidence: 99%

Effect of Puerarin on Expression of ICAM-1 and TNF-α in Kidneys of Diabetic Rats

Pan

Wang

et al. 2015

Med Sci Monit

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Background:As an important factor causing end-stage renal disease, diabetic nephropathy is correlated with low-grade chronic inflammation and immune system activation. This study aimed to investigate the protective function of puerarin on the kidneys of diabetic rats. Material/Methods:A cohort of healthy male SD rats (7 weeks old) were randomly divided into a control group, a model group, and a puerarin treatment group with high (H), moderate (M), and low (L) dosage. After streptozotocin induction, puerarin was applied via intragastric administration for 8 consecutive weeks with dosages of 0.25, 0. 5 and 1.0 mg/(kg·d) for L, M, and H groups, respectively. Fasting blood glucose (BG), creatinine (Scr), urea nitrogen (BUN), and urine albumin excretion rate (UAER) were measured, along with morphological observation of renal cells. The expression of intracellular adhesion molecule 1 (ICAM-1) and tumor necrosis factor a (TNF-a) was determined using immunohistochemical (IHC) staining, while renal cortex cell apoptosis was assayed by in situ end-labeling method. Results:Model rats had significantly elevated levels of BG, Scr, BUN, and UAER compared to controls (p<0.05). All these increases were partially but significantly suppressed by puerarin (p<0.05), which also caused marked improvement of histopathological damages. Puerarin at each dosage significantly eliminated elevations of ICAM-1 and TNF-a levels in model rats (p<0.05), and decreased apoptotic indexes of renal cortex cells (p<0.05). Conclusions:Early-stage renal damages can be significantly improved by puerarin, possibly via its suppression of ICAM-1 and TNF-a expression in diabetic rat kidneys.

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Association of circulating sTRAIL and high-sensitivity CRP with type 2 diabetic nephropathy and foot ulcers

Cited by 17 publications

References 19 publications

Assessment of serum neopterin as an inflammatory and cardiovascular marker in type 1 and 2 diabetes complicated by diabetic foot syndrome: a comparative study

Assessment of serum neopterin as an inflammatory and cardiovascular marker in type 1 and 2 diabetes complicated by diabetic foot syndrome: a comparative study

Evaluation of soluble CD200 levels in type 2 diabetic foot and nephropathic patients: Association with disease activity

Effect of Puerarin on Expression of ICAM-1 and TNF-α in Kidneys of Diabetic Rats

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