Association of coffee consumption with risk of colorectal cancer: a meta-analysis of prospective cohort studies

Gan, Yong; Wu, Jiang; Zhang, Shengchao; Li, Liqing; Cao, Shiyi; Mkandawire, Naomie; Ji, Kun; Herath, Chulani; Gao, Chao; Xu, Hong; Zhou, Yanfeng; Song, Xingyue; Chen, Shanquan; Chen, Yawen; Yang, Tingting; Li, Jing; Qiao, Yan; Hu, Sujuan; Yin, Xiaoxv; Lu, Zuxun

doi:10.18632/oncotarget.8627

Cited by 42 publications

(48 citation statements)

References 54 publications

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“…Meta-analyses of prospective cohort studies worldwide 12,13,34 and in Japan 20 did not detect any increase in the risk of rectal cancer associated with coffee drinking. Among never smokers, however, an increased risk was observed in both women and men.…”

Section: Discussionmentioning

confidence: 79%

“…Among never smokers, however, an increased risk was observed in both women and men. Meta-analyses of prospective cohort studies worldwide 12,13,34 and in Japan 20 did not detect any increase in the risk of rectal cancer associated with coffee drinking. The observed association with rectal cancer in the present subgroup analyses should be interpreted with caution due to the small number of cases comprising the subgroup.…”

Section: Discussionmentioning

confidence: 79%

“…33 The present findings are also consistent with our previous meta-analysis of Japanese cohort studies, 20 where no association was found between coffee consumption and colorectal cancer. Interestingly, a meta-analysis of prospective cohort studies showed that coffee drinking was not associated with colorectal cancer risk in an analysis comparing the high versus low consumption (HR 0.98), whereas coffee drinking was significantly inversely associated with risk of colorectal cancer in a doseresponse analysis comparing those consuming 6 cups/day with nondaily drinkers (HR 0.93, 0.90, and 0.87 for 6 cups/ day, 7 cups/day and 8 cups/day, respectively), 34 suggesting a threshold for whatever anticarcinogenic effect there may be for coffee drinking. The authors of the US cohort study ascribed their findings to the use of a standard questionnaire in a single defined population and a comparatively higher number of incident cases.…”

Section: Discussionmentioning

confidence: 97%

“…The US cohort study 16 detected a reduction in risk only for those who drank 4-5 cups/day and 6 cups/day but not for those who drank 3 cups/day, as compared to non-coffee-drinkers. Interestingly, a meta-analysis of prospective cohort studies showed that coffee drinking was not associated with colorectal cancer risk in an analysis comparing the high versus low consumption (HR 0.98), whereas coffee drinking was significantly inversely associated with risk of colorectal cancer in a doseresponse analysis comparing those consuming 6 cups/day with nondaily drinkers (HR 0.93, 0.90, and 0.87 for 6 cups/ day, 7 cups/day and 8 cups/day, respectively), 34 suggesting a threshold for whatever anticarcinogenic effect there may be for coffee drinking.…”

Section: Discussionmentioning

confidence: 97%

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Coffee drinking and colorectal cancer and its subsites: A pooled analysis of 8 cohort studies in Japan

Kashino

Akter

Mizoue

et al. 2018

Intl Journal of Cancer

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Coffee is a rich source of bioactive compounds that have potential anticarcinogenic effects. However, it remains unclear whether coffee drinking is associated with colorectal cancer. Also, despite different etiological factors involved in gut physiology, few studies have investigated this association by anatomical site of the lesion. To address these issues, this study examined the association between coffee drinking and colorectal cancer in a pooled analysis from 8 cohort studies conducted in Japan. Among 320,322 participants followed up for 4,503,274 person-years, 6,711 incident colorectal cancer cases were identified. Study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using the random effects model. Coffee drinking was not materially associated with colorectal cancer risk in men or women (pooled HR 0.92, 95% CI 0.82-1.03 in men and pooled HR 0.90, 95% CI 0.76-1.07 in women). Analysis by subsite showed a lower risk of colon cancer among female drinkers of ≥3 cups coffee/day (pooled HR 0.80, 95% CI 0.64-0.99). There was no such association in men. Coffee drinking was not associated with risk of rectal cancer in men or women. Results were virtually the same among never smokers except for an increased risk of rectal cancer associated with frequent coffee consumption. Coffee drinking may be associated with lower risk of colon cancer in Japanese women.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

See 2 more Smart Citations

Coffee drinking and colorectal cancer and its subsites: A pooled analysis of 8 cohort studies in Japan

Kashino

Akter

Mizoue

et al. 2018

Intl Journal of Cancer

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“…Indeed, preceding meta-analysis or cohort studies have reported that coffee consumption was associated with both reduced (3) and non-increased (1,2,(7)(8)(9) risk of all-sites cancer mortality. However, its association with the risk of site-specific cancer incidence, such as breast cancer (10,11) colon cancer, (12,13) pancreas cancer, (14)(15)(16) liver cancer, (17)(18)(19) and prostate cancer (20) is also controversial. Furthermore, the effect of coffee consumption on all-sites cancer incidence has not been extensively investigated.…”

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confidence: 99%

Association between coffee consumption and all‐sites cancer incidence and mortality

et al. 2017

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The preventive effect of coffee on cancer at different sites has been reported, but the effect on all‐sites cancer incidence has not been extensively investigated. We evaluated the association between frequency of coffee consumption and risk of all‐sites cancer incidence and mortality among 39 685 men and 43 124 women (age 40–79 years, at baseline), in the Three‐Prefecture Cohort Study. The association between frequency of coffee consumption and risk of all‐sites cancer incidence and mortality was assessed by a Cox proportional hazards regression model, adjusted for potential confounders. During 411 341 person‐years among men and 472 433 person‐years among women, a total of 4244 men and 2601 women developed cancer at different sites and a total of 3021 men and 1635 women died of cancer at different sites. We showed an inverse association between frequency of coffee consumption and all‐sites cancer incidence in both men and women. Comparing participants who consumed coffee with those who never drank coffee, the adjusted hazard ratios (95% confidential interval) for all‐sites cancer incidence was 0.74 (0.62–0.88) for coffee consumption of ≥5 cups/day in men (P for trend < 0.001) and 0.76 (0.58–1.02) in women (P for trend = 0.020). Coffee consumption frequency was inversely associated with mortality from all‐sites cancer. In this population, increasing coffee consumption resulted in a decreased risk of all‐sites cancer incidence and mortality.

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Association of Coffee Drinking With Mortality by Genetic Variation in Caffeine Metabolism

et al. 2018

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and Asia show consistent inverse associations between coffee drinking and mortality, including deaths from cardiovascular disease and some cancers. However, concerns about coffee, particularly among people with common genetic polymorphisms affecting caffeine metabolism and among those drinking more than 5 cups per day, remain.OBJECTIVE To evaluate associations of coffee drinking with mortality by genetic caffeine metabolism score. DESIGN, SETTING, AND PARTICIPANTSThe UK Biobank is a population-based study that invited approximately 9.2 million individuals from across the United Kingdom to participate. We used baseline demographic, lifestyle, and genetic data form the UK Biobank cohort, with follow-up beginning in 2006 and ending in 2016, to estimate hazard ratios (HRs) for coffee intake and mortality, using multivariable-adjusted Cox proportional hazards models. We investigated potential effect modification by caffeine metabolism, defined by a genetic score of previously identified polymorphisms in AHR, CYP1A2, CYP2A6, and POR that have an effect on caffeine metabolism. Of the 502 641 participants who consented with baseline data, we included those who were not pregnant and had complete data on coffee intake and smoking status (n = 498 134).EXPOSURES Total, ground, instant, and decaffeinated coffee intake. MAIN OUTCOMES AND MEASURESAll-cause and cause-specific mortality. RESULTSThe mean age of the participants was 57 years (range, 38-73 years); 271 019 (54%) were female, and 387 494 (78%) were coffee drinkers. Over 10 years of follow-up, 14 225 deaths occurred. Coffee drinking was inversely associated with all-cause mortality. Using non-coffee drinkers as the reference group, HRs for drinking less than 1, 1, 2 to 3, 4 to 5, 6 to 7, and 8 or more cups per day were 0.94 (95% CI, 0.88-1.01), 0.92 (95% CI, 0.87-0.97), 0.88 (95% CI, 0.84-0.93), 0.88 (95% CI, 0.83-0.93), 0.84 (95% CI, 0.77-0.92), and 0.86 (95% CI, 0.77-0.95), respectively. Similar associations were observed for instant, ground, and decaffeinated coffee, across common causes of death, and regardless of genetic caffeine metabolism score. For example, the HRs for 6 or more cups per day ranged from 0.70 (95% CI, 0.53-0.94) to 0.92 (95% CI, 0.78-1.10), with no evidence of effect modification across strata of caffeine metabolism score (P = .17 for heterogeneity). CONCLUSIONS AND RELEVANCECoffee drinking was inversely associated with mortality, including among those drinking 8 or more cups per day and those with genetic polymorphisms indicating slower or faster caffeine metabolism. These findings suggest the importance of noncaffeine constituents in the coffee-mortality association and provide further reassurance that coffee drinking can be a part of a healthy diet.

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Association of coffee consumption with risk of colorectal cancer: a meta-analysis of prospective cohort studies

Cited by 42 publications

References 54 publications

Coffee drinking and colorectal cancer and its subsites: A pooled analysis of 8 cohort studies in Japan

Coffee drinking and colorectal cancer and its subsites: A pooled analysis of 8 cohort studies in Japan

Association between coffee consumption and all‐sites cancer incidence and mortality

Association of Coffee Drinking With Mortality by Genetic Variation in Caffeine Metabolism

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