Association of Coffee, Decaffeinated Coffee and Caffeine Intake from Coffee with Cognitive Performance in Older Adults: National Health and Nutrition Examination Survey (NHANES) 2011–2014.

Dong, Xiaofeng; Li, Shiru; Sun, Jing; Li, Yan; Zhang, Dongfeng

doi:10.3390/nu12030840

Cited by 133 publications

(118 citation statements)

References 51 publications

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“…Another limitation of the experimental studies is that most of them were carried out on male animals (or the animal sex was not stated), whereas human studies indicate that the effect of caffeine on cognition is sex-dependent [ 95 , 200 , 201 ]. For example, caffeine intake was associated with better cognitive performance in older women, but not in men [ 202 ].…”

Section: Discussionmentioning

confidence: 99%

“…Decaffeinated coffee constituents have been demonstrated to exert potential beneficial effects in neurodegenerative diseases [ 94 ]. However, decaffeinated coffee was not associated with a protective effect on cognitive performance in older people [ 95 ]. The data from the human studies do not allow to conclude on the role of caffeine itself in the modulation of AD risk.…”

Section: Caffeine In Alzheimer’s Diseasementioning

confidence: 99%

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Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies

et al. 2021

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Alzheimer’s disease (AD) is the most common type of dementia leading to progressive memory loss and cognitive impairment. Considering that pharmacological treatment options for AD are few and not satisfactory, increasing attention is being paid to dietary components that may affect the development of the disease. Such a dietary component may be caffeine contained in coffee, tea or energy drinks. Although epidemiological data suggest that caffeine intake may counteract the development of cognitive impairment, results of those studies are not conclusive. The aim of the present study is to review the existing experimental studies on the efficacy of caffeine against AD and AD-related cognitive impairment, focusing on the proposed protective mechanisms of action. In conclusion, the reports of studies on experimental AD models generally supported the notion that caffeine may exert some beneficial effects in AD. However, further studies are necessary to elucidate the role of caffeine in the effects of its sources on cognition and possibly AD risk.

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Section: Discussionmentioning

confidence: 99%

Section: Caffeine In Alzheimer’s Diseasementioning

confidence: 99%

Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies

et al. 2021

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“…An intervention study showed that the biomarkers of oxidative damage chosen such as 3-nitrotyrosine were lower in high level consumers of instant coffee compared to those who consumed water, suggesting that the consumption of coffee may protect healthy adults from the oxidative damage [ 163 ]. In a clinical study with a total of 2513 participants aged ≥60 years, Dong et al [ 164 ] found that the prevalence of low cognitive performance decreased with increasing intake of total coffee and caffeinated coffee with a nonlinear, L-shaped dose–response relationship. However, no significant association was found between decaffeinated coffee and cognitive performance.…”

Section: Other Ndds and Healthy Subjectsmentioning

confidence: 99%

Beneficial Effects of Epigallocatechin-3-O-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative Diseases

Fukutomi¹,

Ohishi

Koyama

et al. 2021

Molecules

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Many observational and clinical studies have shown that consumption of diets rich in plant polyphenols have beneficial effects on various diseases such as cancer, obesity, diabetes, cardiovascular diseases, and neurodegenerative diseases (NDDs). Animal and cellular studies have indicated that these polyphenolic compounds contribute to such effects. The representative polyphenols are epigallocatechin-3-O-gallate in tea, chlorogenic acids in coffee, resveratrol in wine, and curcumin in curry. The results of human studies have suggested the beneficial effects of consumption of these foods on NDDs including Alzheimer’s and Parkinson’s diseases, and cellular animal experiments have provided molecular basis to indicate contribution of these representative polyphenols to these effects. This article provides updated information on the effects of these foods and their polyphenols on NDDs with discussions on mechanistic aspects of their actions mainly based on the findings derived from basic experiments.

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“…Caffeine attributes to most cognitive benefits. There are mixed studies depicting the positive association of decaffeinated coffee compared to caffeinated coffee affecting cognitive performance [30]. A recent publication by Dong et al concluded from the National Health and Nutrition Examination Survey (NHANES), which was conducted by Centers for Disease Control and Prevention (CDC), that coffee, caffeinated coffee, and caffeine were associated with cognitive performance while decaffeinated coffee was not [30].…”

Section: Review Bioactive Compounds Of Coffee and Their Propertiesmentioning

confidence: 99%

Neuroprotective and Neurodegenerative Aspects of Coffee and Its Active Ingredients in View of Scientific Literature

Wasim

Kukkar

Awad

et al. 2020

Cureus

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Coffee and its components have several neuroprotective properties that lower the risk of cognitive decline and other neurodegenerative diseases. This study reviews the mechanisms by which coffee and its respective compounds affect the brain and its pathologies. Many epidemiological studies in this literature review have shown coffee to reduce the risk of developing dementia, stroke, and Alzheimer's disease. It may also have a positive impact on the disease course of amyotrophic lateral sclerosis, Parkinson's disease, and depression. The optimal benefits achieved from coffee in these pathologies rely on higher daily doses. Most of its effects are attributed to caffeine by the antagonism of adenosine receptors in the central nervous system; however, other coffee constituents like chlorogenic acids have also shown much promise in therapeutic value. Existing research considers coffee to have great potential, but additional studies are still needed to clarify the mechanisms and actual causal relationships in certain neuropathologies.

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Association of Coffee, Decaffeinated Coffee and Caffeine Intake from Coffee with Cognitive Performance in Older Adults: National Health and Nutrition Examination Survey (NHANES) 2011–2014.

Cited by 133 publications

References 51 publications

Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies

Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies

Beneficial Effects of Epigallocatechin-3-O-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative Diseases

Neuroprotective and Neurodegenerative Aspects of Coffee and Its Active Ingredients in View of Scientific Literature

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