Association of cognitive activities of daily living (ADL) function and nonmotor burden in nondemented Parkinson’s disease patients.

Abstract

Objective: In Parkinson's disease (PD), nonmotor symptoms (NMS) considerably influence disease progression and cognitive decline. Depression, anxiety, sleep disturbances, and hallucinations (DASH), may indicate a risk for dementia (PDD). Mild impairments in activities of daily living (ADL) caused by cognitive dysfunction are also present in the prodromal stage of PDD. The association of both factors has been sparsely investigated. Aim was to evaluate these specific NMS in a large nondemented PD cohort and their co-occurrence with cognitive dysfunction and ADL impairments. Method: Data of 226 PD

Arithmetic Errors in Financial Contexts in Parkinson’s Disease

“…The binary logistic regressions showed attention, visuospatial/constructional function, and story memory predicted arithmetic errors, suggesting degeneration in these domains at least partly causing arithmetic deficits. Current research in PD also discusses the importance of attention and visuospatial function for cognitive status und progression to PDD, introducing these domains as candidates for early biomarkers (Lopes et al, 2017;Becker et al, 2020). Associations between visuo-spatial/constructional functions and numerosity in healthy adults are in line with finding visuo-spatial/constructional functions to predict arithmetic errors in the current study (Lammertyn et al, 2002;Thompson et al, 2013).…”

“…The binary logistic regression including ADL explained no more than a small amount of variance in arithmetic errors. The insignificant effect might be explained by patients in the current study being less heavily impacted on ADL, with ADL impairment occurring later in the process of transition from PD-MCI to PDD (Becker et al, 2020).…”

One-Year Changes in Activities of Daily Living, Usability, Falls and Concerns about Falling, and Self-Rated Health for Different Housing Adaptation Client Profiles

“…Adults with high level of disability, and older adults with medium level of disability including at least moderate cognitive impairment had cognitive impairments already at baseline, and their patterns of decline or no change over time were expected. People with cognitive impairments increasingly become dependent in ADL and other activities [ 38 , 39 ], and they, to a large extent, lack the capacity to adapt to functional decline and to changes in the physical environment [ 40 ]. They most often reduce the number of activities they perform or perform them with significant assistance from others.…”