Association of complete blood cell counts with metabolic syndrome in an elderly population

Abstract

BackgroundMetabolic syndrome’s (MetS) role in predicting cardiovascular diseases and diabetes has been confirmed in many large cohort studies. Nontraditionally, hematogram components are significantly related to MetS in many different age groups. However, little is known about its role among the elderly.MethodsWe enrolled 18,907 subjects over the age of 65 years who underwent regular health examinations. They were divided into three groups according to age: young old (YO: ≥ 65 and < 74 years old), old old (OO: ≥ 75 and < 84 years old), and oldest old (ODO: ≥ 85 years old). The MetS components were determined, and correlations between MetS and hematogram components were evaluated using Pearson and multivariate linear regression analyses. The hematogram components were the independent variables evaluated separately against the dependent variable (MetS components).ResultsWhile SBP and HDL-C increased, most other MetS and hematogram parameters decreased in men with age. Fewer significant differences were noted among the women. In the YO and OO groups for both genders, the subjects with MetS had higher WBC and Hb. None of the hematogram components were different for subjects with or without MetS in the ODO group. Multiple regression results show that most of the relationships between hematogram and MetS components disappeared in the ODO groups. The WBC levels were mainly correlated with WC and TG. At the same time, Hb was associated with BP, FPG, and LDL-C. Compared to WBC and Hb, PLT was least related to MetS, except in the cases of LDL-C and TG. Among the MetS components, BMI, LDL-C, and TG were consistently related to all the hematogram components in YO and OO men. However, only TG had the same consistency among YO and OO women.ConclusionsThis study’s three major findings are as follows: WBC and Hb are associated with MetS, even among the YO and OO groups, regardless of gender; among the three hematogram components, Hb had the strongest and PLT had the weakest correlation with MetS; and TG is not the only component with relatively higher r values, and it is related to all hematogram components.

Predicting young-onset type 2 diabetes mellitus with metabolic syndrome components in healthy young adults

“…In the present study, subjects with higher FPG levels had the second highest hazard ratio among the other MetS components. This finding contradicts the results of our previous reports and several other major studies in populations of other ages . In these studies, compared to other MetS components, FPG has always been shown to be less related to other parameters such as uric acid, haemoglobin, or insulin resistance.…”

“…This finding contradicts the results of our previous reports and several other major studies in populations of other ages. [22][23][24] In these studies, compared to other MetS components, FPG has always been shown to be less related to other parameters such as uric acid, haemoglobin, or insulin resistance. This contradiction can be explained by the complex interaction between insulin secretion and resistance.…”

Relationship between platelet count and platelet width distribution and serum uric acid concentrations in patients with untreated essential hypertension

“…Additionally normocytic anemia is common among hypertensive patients. Lower hemoglobin concentrations were found in patients with uncontrolled than among those with well controlled HTN, indicating a higher cardiovascular risk in uncontrolled HTN . In this study, HGB and HCT mean values did not differ significantly between hypertensive hyperuricemic subjects and nonhypertensive hyperuricemic subjects.…”

Metabolic Syndrome Is Associated with Oxidative Stress and Proinflammatory State

“…More concretely, it has been evidenced that the number of circulating neutrophils, monocytes, and lymphocytes are positively correlated with BMI, body fat, and insulin resistance [38]. Moreover, the prevalence of MetS and MetS components increases white blood cell count in both men and women, which may be useful as a marker of low-grade systemic inflammation and cardiovascular disease risk [39,40].…”