Association of contrast sensitivity with LogMAR visual acuity and glycosylated hemoglobin in non-insulin dependent diabetes mellitus

Abstract

A tertiary care center-based prospective case-control study was undertaken to evaluate the association of contrast sensitivity with LogMAR visual acuity and glycosylated hemoglobin (HbA1c) in 205 cases of non-insulin dependent diabetes mellitus and 115 controls. LogMAR visual acuity and contrast sensitivity were scored using ETDRS and Pelli-Robson charts, respectively. Bivariate correlation between contrast sensitivity and LogMAR visual acuity showed significant inverse correlation in cases without retinopathy (r = -0.466) and with non-proliferative retinopathy (r = -0.307). In a multivariate model, on applying linear regression analysis, LogMAR visual acuity (p < 0.001) and HbA1c (p = 0.002) had significant association with contrast sensitivity. Significant difference in contrast sensitivity was not observed between cases without diabetic retinopathy and with non-proliferative diabetic retinopathy, implying no association with retinal microvascular changes. Contrast sensitivity dysfunction observed in diabetes mellitus results from changes in retinal function secondary to alteration in carbohydrate metabolism depicted in glycosylated hemoglobin.

Contrast Sensitivity in Diabetic Patients without Retinopathy And It’s Correlation with the Duration of Diabetes And Glycemic Control

“…(6) Misra et al also found association between contrast sensitivity and visually acuity as well as glycosylated haemoglobin in patients with Type 2 Diabetes Mellitus. (7) Our study found that there is some reduction in contrast sensitivity in diabetic patients even before they develop visible retinal changes on ophthalmoscopy. However this reduction is not statistically significant when compared with healthy controls.…”

Retinal sensitivity changes associated with diabetic neuropathy in the absence of diabetic retinopathy

“…Prediabetic hyperinsulinemia and toxic inflammatory factors might affect the ganglion cell layer of the neural retina, resulting in reduced visual functions including contrast sensitivity 22. Results from our study demonstrate that subjects with DN have reduced contrast sensitivity compared with those without DN.…”

Contrast sensitivity is associated with outer‐retina thickness in early‐stage diabetic retinopathy

“…; McAnany & Park ,, ), letter contrast sensitivity (CS) (Stavrou & Wood ; Misra et al. ; McAnany & Park ) and MP sensitivity (Verma et al. ; Nittala et al.…”