Association of CRP, CD14, Pro-Inflammatory Cytokines and Their Receptors (TNFA, LTA, TNFRSF1A, TNFRSF1B, IL1B, and IL6) Genes with Chronic Obstructive Pulmonary Disease Development

Korytina, G. F.; Akhmadishina, L. Z.; Kochetova, O. V.; Aznabaeva, Yu. G.; Измайлова, С. М.; Загидуллин, Ш. З.; Victorova, T. V.

doi:10.1134/s1022795420080086

Cited by 2 publications

(1 citation statement)

References 27 publications

(27 reference statements)

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“…The lincRNA_2411 .6 was 11 × over-expressed in the mastitic samples compared to the healthy samples (FC = 11.31, FDR = 3.19E-02) and is predicted to interact with TNFRSF1A which is located upstream. This receptor encodes the type 1 receptor for tumor necrosis factor - α (TNFα) 58 , which is a pro-inflammatory cytokine secreted by inflammatory cells 59 . Numerous studies have investigated TNF α in relation to mastitis and have found that concentrations increase during mastitis caused by E .…”

Section: Resultsmentioning

confidence: 99%

Novel lncRNA regulatory elements in milk somatic cells of Holstein dairy cows associated with mastitis

Asselstine,

Medrano,

Muniz

et al. 2024

Commun Biol

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Despite regulatory elements such as long non - coding RNAs representing most of the transcriptome, the functional understanding of long non - coding RNAs in relation to major health conditions including bovine mastitis is limited. This study examined the milk somatic cell transcriptome from udder quarters of 6 Holstein dairy cows to identify differentially expressed long non - coding RNAs using RNA - Sequencing. Ninety - four differentially expressed long non - coding RNAs are identified, 5 of which are previously annotated for gene name and length, 11 are annotated for gene name and 78 are novel, having no gene name or length previously annotated. Significant inflammatory response and regulation of immune response pathways (false discovery rate < 0.05) are associated with the differentially expressed long non - coding RNAs. QTL annotation analysis revealed 31 QTL previously annotated in the genomic regions of the 94 differentially expressed long non - coding RNAs, and the majority are associated with milk traits. This research provides a better understanding of long non - coding RNAs regulatory elements in milk somatic cells, which may enhance current breeding strategies for more adaptable or high mastitis resistant cattle.

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Section: Resultsmentioning

confidence: 99%

Novel lncRNA regulatory elements in milk somatic cells of Holstein dairy cows associated with mastitis

Asselstine,

Medrano,

Muniz

et al. 2024

Commun Biol

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Cartographic atlas of frequency variation for 45 pharmacogenetic markers in populations of Russia and its neighbor states

Balanovskaya¹,

Петрушенко

Кошель

et al. 2020

BRSMU

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The lack of information about the frequency of pharmacogenetic markers in Russia impedes the adoption of personalized treatment algorithms originally developed for West European populations. The aim of this paper was to study the distribution of some clinically significant pharmacogenetic markers across Russia. A total of 45 pharmacogenetic markers were selected from a few population genetic datasets, including ADME, drug target and hemostasis-controlling genes. The total number of donors genotyped for these markers was 2,197. The frequencies of these markers were determined for 50 different populations, comprised of 137 ethnic and subethnic groups. A comprehensive pharmacogenetic atlas was created, i.e. a systematic collection of gene geographic maps of frequency variation for 45 pharmacogenetic DNA markers in Russia and its neighbor states. The maps revealed 3 patterns of geographic variation. Clinal variation (a gradient change in frequency along the East-West axis) is observed in the pharmacogenetic markers that follow the main pattern of variation for North Eurasia (13% of the maps). Uniform distribution singles out a group of markers that occur at average frequency in most Russian regions (27% of the maps). Focal variation is observed in the markers that are specific to a certain group of populations and are absent in other regions (60% of the maps). The atlas reveals that the average frequency of the marker and its frequency in individual populations do not indicate the type of its distribution in Russia: a gene geographic map is needed to uncover the pattern of its variation.

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Association of CRP, CD14, Pro-Inflammatory Cytokines and Their Receptors (TNFA, LTA, TNFRSF1A, TNFRSF1B, IL1B, and IL6) Genes with Chronic Obstructive Pulmonary Disease Development

Cited by 2 publications

References 27 publications

Novel lncRNA regulatory elements in milk somatic cells of Holstein dairy cows associated with mastitis

Novel lncRNA regulatory elements in milk somatic cells of Holstein dairy cows associated with mastitis

Cartographic atlas of frequency variation for 45 pharmacogenetic markers in populations of Russia and its neighbor states

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