Association of CTLA4 Gene Polymorphism in Iranian Patients with Ankylosing Spondylitis

Abstract

This study could suggest an association between specific allele in the promoter region of CTLA4 gene and AS disease.

The associations between PD-1, CTLA-4 gene polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis and systemic review

“…Through electronic and manual searching methods, we identified forty-one potentially relevant investigations and twenty of these were chose for full-text review based on title or abstract details [17][18][19][20][21][22][23][24][30][31][32][33][34][35][36][37][38][39][40][41]. Twelve studies were excluded because either they were not about the association between PD-1, CTLA-4 polymorphisms and the risk of AS, or they contained no extractable data, other polymorphism data or review [30][31][32][33][34][35][36][37][38][39][40][41].…”

“…Twelve studies were excluded because either they were not about the association between PD-1, CTLA-4 polymorphisms and the risk of AS, or they contained no extractable data, other polymorphism data or review [30][31][32][33][34][35][36][37][38][39][40][41]. Finally, we enrolled a total of eight published articles, which met our inclusion criteria [17][18][19][20][21][22][23][24] (Fig. 1).…”

“…Meta-analysis was performed on the CTLA-4-308 T/C and +49 G/A polymorphisms. For CTLA-4-308 T/C polymorphism, there were only two studies regarding this polymorphism and the risk of AS [22,23]. There was no evidence of heterogeneity under the allele model (T versus C: I 2 = 0.0 %, P heterogeneity = 0.661), the dominant model (TT+TC versus CC: I 2 = 0.0 %, P heterogeneity = 0.595), the recessive model (TT versus CC+TC: I 2 = 0.0 %, P heterogeneity = 0.589) and the additive model (TT versus CC: I 2 = 0.0 %, P heterogeneity = 0.558).…”

“…More than 100 polymorphisms had been identified in the CTLA-4 gene, and of these polymorphisms, CTLA-4 +49 A/G and −318 C/T polymorphisms had been best investigated in AS. However, the relationships between those polymorphisms and susceptibility to AS remain unclear; some studies on association between PD-1, CTLA-4 polymorphisms and AS risk had used comparatively small samples [17][18][19][20][21][22][23][24], and the results about the role of PD-1 or CTLA-4 gene polymorphisms in AS patients are inconsistent and inconclusive.…”

Untitled

“…14 Several researchers have examined whether genetic polymorphisms in the CTLA-4 gene are associated with various conditions such as autoimmune diseases. [15][16][17][18][19] In particular, some studies of genetic polymorphisms in human liver and kidney transplant have suggested that CTLA-4 may play a minor role in allograft rejection. 7,20 Many of the reports have been inconclusive 21 ; therefore, they can be considered as substantial genes for determining non-HLA risk related to organ transplant.…”