Association of CTLA4 single nucleotide polymorphisms with viral but not autoimmune liver disease

Abstract

We describe the association of the CTLA4 -318C>T variation with chronic HBV infection and cryptogenic cirrhosis but find no association of the +49G>A variation with autoimmune liver disease.

Association analysis of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients

“…Although early studies found an association between SNP 49G coding and PBC [22][23][24], ensuing reports showed negative relationships with susceptibility [25][26][27][28][29][30] or a positive association with liver damage [31]. A recent investigation reported that rs231725 in the 3'…”

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“…12 Several reports have shown that CTLA-4 gene polymorphisms may be associated with the susceptibility and chronicity of the disease in HBV-infected patients; however, the results are controversial. [9][10][11][12] Gu and associates reported that the A allele instead of CTLA4 49A/G (rs231775) polymorphisms enhances the inhibitory effect on T-cell activation, and the A/G variant may decrease the HBV clearance capability of T cells; thus, increasing HBV-related HCC susceptibility. 12 Duan and associates evaluated the CTLA-4 49A/G and 318 T/C polymorphisms in 172 chronic HBV-infected patients.…”

“…41 The diversity in a HBV clinical course was largely related to the host immunologic genetic variety especially costimulatory molecules which have roles in immune responses. 10,11,9,42 Therefore according to, the importance of costimulatory molecules, in this study their genetic variations was evaluated in allogeneic and autologous HSCT patients with and without HBV. The CTLA-4 preserves T-cell homeostasis and induces Fas-independent apoptosis of activated T cells elicited.…”

“…9 Alizadeh et al and Schott et al have shown a significant association between CTLA-4 -318 C/T with a susceptibility to chronic HBV infection. 10,11 Jiang and associates showed that the GG genotype of the CTLA-4 49A/G in Chinese liver transplant patients is related to a reduced risk of the HBV recurrence. 43 Han and associates have shown a relation between the GG genotype of the CTLA-4 49A/G, with the lower TNF-α and IFN-γ levels in patients with chronic HBV infection.…”

“…8 Cytotoxic T-lymphocyte antigen-4 gene polymorphisms, which may affect the function of CTLA4 in regulating the immune response, has been proposed to affect the susceptibility and chronicity of the disease in patients with HBV infection; however, the results are still controversial. [9][10][11][12]2 Similar to CTLA4, CD28 also binds to B7 family of receptors (CD80 and CD86), but it provides a positive costimulatory signal for T-cell proliferative response after being expressed on T cells. 13,14 Several polymorphisms in the CD28 gene may affect the intensity of T-cell-mediated immunity, resulting in various autoimmune diseases, and the occurrence of post transplant allograft rejection.…”