Association of CYP2E1 and NAT2 Polymorphisms with Lung Cancer Susceptibility among Mongolian and Han Populations in the Inner Mongolian Region

CYP2E1 and GSTM1 gene polymorphisms, environmental factors, and the susceptibility to lung cancer

“…Wang et al found that there were significant differences in the distribution of RsaI genotypes between the 2 groups—the homozygous mutant (c2/c2 (TT)) in the control group was 6.9%, but in patients with lung cancer, it was only 0.8%. Zhang's study on Mongolian and Han populations in the Inner Mongolian Region showed that c1 compared c2 with the OR = 1.382, 95% CI = 1.178‐1.587, P = .003. Our study also showed that the frequency of TT of CYP2E1 in patients with lung cancer was significantly lower (2.2%) than the control group (6.4%), and that the risk of lung cancer in homozygous mutant (TT) patients was significantly lower (OR = 0.24, 95% CI = 0.07‐0.76, P = .015) compared with CC and CT.…”

“…T A B L E 2 Logistic regression analysis of genetic polymorphism and susceptibility to lung cancer 2 groups-the homozygous mutant (c2/c2 (TT)) in the control group was 6.9%, but in patients with lung cancer, it was only 0.8%. Zhang's study 3…”

“…CYP2E1 RsaI polymorphism consists of wild CC genotype, heterozygous CT genotype, and homozygous mutation TT genotype, which is caused by the C‐T replacement in 5′ regulatory region. Studies show that the CYP2El RsaI polymorphism is closely related to the susceptibility to lung cancer, but results are not consistent …”

“…RsaI polymorphism is closely related to the susceptibility to lung cancer, but results are not consistent. [2][3][4][5][6] Glutathione S-transferase (GST) is a phase II enzyme. The unequal exchange of homologous chromosomes in the highly homologous region of the glutathione S-transferase M1 (GSTM1) gene leads to the loss of 15KB bases, forming the GSTM1 ± polymorphism; this polymorphism includes the function type GSTM1 (+), and the homozygous deletion genotype GSTM1 (−).…”

Note of clarification of data on the association between CYP2E1 RsaI polymorphism and lung cancer risk

“…It is required to clarify the association between CYP2E1 RsaI polymorphism and lung cancer risk. Moreover, several newly published papers [5][6][7][8][9][10] on this topic have emerged since then. We re-conducted a systematic meta-analysis to clarify the association between CYP2E1 RsaI polymorphism and lung cancer risk on the basis of a total of 31 studies with 6848 cases and 8782 controls, which may provide comprehensive evidence for the association of CYP2E1 RsaI polymorphism with lung cancer risk.…”