Association of Cystatin C with Measures of Obesity and Its Impact on Cardiovascular Events Among Healthy US Adults

Panaich, Sidakpal; Veeranna, Vikas; Bavishi, Chirag; Zalawadiya, Sandip; Kottam, Anupama; Afonso, Luís

doi:10.1089/met.2014.0018

Cited by 7 publications

(4 citation statements)

References 28 publications

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“…Another study illustrated a stronger correlation between CysC and WC compared to BMI. [40] These data indicate that the close association between CysC and MetS may be mediated by visceral fat.…”

Section: Discussionmentioning

confidence: 91%

Association of body mass index, waist circumference, and metabolic syndrome with serum cystatin C in a Chinese population

Xiao

Jiang²,

Qin³

et al. 2017

Medicine

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Background: The aim of the study was to evaluate the association of body mass index (BMI), waist circumference (WC), and metabolic syndrome (MetS) with serum cystatin C (CysC) in a Chinese population.Methods: The population was composed of 5866 subjects. MetS was diagnosed using the American Heart Association/National Heart, Lung, and Blood Institute 2005 (NCEP-R) criteria. Covariates were analyzed using logistic regression and Spearman partial correlation.Results: In this population, triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG), high sensitivity C-reactive protein (hs-CRP), BMI, WC, systolic blood pressure (SBP), diastolic blood pressure (DBP), serum creatinine (Scr), and CysC were significantly higher, and HDL-C and the estimated glomerular filtration rate (Chronic Kidney Disease Epidemiology Collaboration) (eGFR CKD-EPI ) were significantly lower in the MetS than in the non-MetS group. TG, LDL-C, FPG, hs-CRP, BMI, WC, SBP, DBP, and Scr were significantly higher, and HDL-C and eGFR CKD-EPI were significantly lower in the 4th quartile than in the 1st quartile of CysC. Logistic regression analysis showed that sex, age, hs-CRP, and CysC were independently associated with the presence of MetS (OR = 3.732, 1.028, 1.051, and 3.334, respectively; P < 0.05). No significant association between the presence of MetS and either Scr or eGFR CKD-EPI was observed. After adjustment for age and sex, BMI, WC, hs-CRP, and Scr were all positively correlated, whereas eGFR CKD-EPI was negatively correlated with CysC (r = 0.029, 0.061, 0.189, 0.227, and À0.210, respectively; P < 0.05).Conclusion: The present study revealed that the CysC was more closely associated with the presence of MetS, as compared Scr or eGFR CKD-EPI. CysC was positively correlated with BMI, and more strongly, positively correlated with WC and inflammation.Abbreviations: BMI = body mass index, CysC = cystatin C, DBP = diastolic blood pressure, eGFR CKD-EPI = estimated glomerular filtration rate (Chronic Kidney Disease Epidemiology Collaboration), hs-CRP = high sensitivity C-reactive protein, LDL-C = lowdensity lipoprotein cholesterol, MetS = metabolic syndrome, SBP = systolic blood pressure, Scr = serum creatinine, TG = triglyceride, WC = waist circumference.

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Section: Discussionmentioning

confidence: 91%

Association of body mass index, waist circumference, and metabolic syndrome with serum cystatin C in a Chinese population

Xiao

Jiang²,

Qin³

et al. 2017

Medicine

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“…35 Magnusson 2013 et al, showed that abdominal obesity is significantly associated with increased baseline levels of Cystatin C. Another study illustrated a stronger correlation between Cystatin C and WC compared to BMI. 36,37 Moreover, cystatin C was well expressed in human adipose tissue, subcutaneous and omental fat, says that cystatin C may has a role in inflammation and controlling adipose tissue mass by inhibiting cathepsins. Hence serum Cystatin C causes stability of plaques which benefits the individuals with normal kidney function.…”

Section: Discussionmentioning

confidence: 99%

Cystatin C, oxidative stress and body fat distribution in the middle aged individuals with coronary artery disease

Srilakshmi¹,

Reddy²,

Rambabu³

et al. 2020

IJCBR

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Introduction: Oxidative stress plays an important role in the progression of atherosclerosis, it is the principal cause for coronary artery disease (CAD). Lipid peroxidation product Malondialdehyde (MDA) is an index of oxidative stress. To assess the oxidative stress, MDA and total antioxidant capacity (TAC) are estimated. Body fat distribution was assessed by obesity and blood lipids, which in turn was measured by Body mass index (BMI) and waist circumference (WC). Cystatin C was measured as an emerging cardio vascular risk factor. Materials and Methods: Study consists of two groups, 145 subjects diagnosed with CAD are included in study group and 66 age and sex matched subjects (non CAD) are included in control group. Results: In this study, Cystatin C is highly significant observed in CAD cases than controls. BMI and WC are not significantly increased; whereas significant increase in mean MDA and decrease in mean TAC levels. Conclusion:Oxidative stress is markedly observed in CAD cases, due to toxic effects of ROS. Increase in Cystatin C levels significantly correlated with WC in middle aged individuals.

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“…In a recent trial Panaich et al have tried to explore the link between cystatin C and anthropometric measures and its influence on cardiovascular mortality, and they found that cystatin C corelated better with measures of visceral adiposity that included waist circumference and waist to hip ratio compared to BMI. It appeared to predict cardiovascular outcomes better in those with measures that do not suggest obesity than those who have abnormal anthropometric measures [55].…”

Section: Cystatin C As a Predictor Of Cv Disease In Diabetes Mellitusmentioning

confidence: 96%

Cystatin C and Its Role in Patients with Type 1 and Type 2 Diabetes Mellitus

Bashier

Seddik

Alhashemi

et al. 2015

Advances in Endocrinology

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Diabetes mellitus is the commonest cause of CKD. It is the leading cause of new patients requiring renal replacement therapy, accounting for 40%, 34%, and 30% of cases in United States, Germany, and Australia, respectively. Recent studies have shown that a low-molecular weight protein, cystatin C, freely filtered by the kidneys is a novel biomarker that may be used for detection of early renal dysfunction in patients with type 1 or type 2 diabetes. Cystatin C has also been shown to detect cardiovascular disease in patients with diabetes and it may also be linked with incident type 2 diabetes in obese patients. We aim to review current evidence based literature on use of cystatin C for early detection of diabetic nephropathy due to type 1 and type 2 diabetes in comparison to conventional methods and explore its association with other comorbidities.

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Association of Cystatin C with Measures of Obesity and Its Impact on Cardiovascular Events Among Healthy US Adults

Abstract: CysC correlated better with measures of visceral adiposity (WC and WHR) compared to BMI and appears to be a better predictor of adverse cardiovascular outcomes among those with anthropometric measures not suggestive of obesity compared to those with abnormal measures of anthropometry.

Cited by 7 publications

References 28 publications

Association of body mass index, waist circumference, and metabolic syndrome with serum cystatin C in a Chinese population

Association of body mass index, waist circumference, and metabolic syndrome with serum cystatin C in a Chinese population

Cystatin C, oxidative stress and body fat distribution in the middle aged individuals with coronary artery disease

Cystatin C and Its Role in Patients with Type 1 and Type 2 Diabetes Mellitus

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