Association of cytokine gene polymorphisms with psoriasis in cases from the Nile Delta of Egypt

Abstract

Background:Psoriasis is a chronic inflammatory skin disease with an immunogenetic background. This work was planned to check for the association of polymorphisms related to cytokine genes TNF-α-308 (G/A), IL-10-1082 (G/A), IL-6-174 (G/C), and IL-1Ra (VNTR) with psoriasis in cases from Egypt.Materials and Methods:This work included 46 cases with psoriasis recruited from the Dermatology Departments, University Hospitals, Nile Delta region of Egypt. They included 14 males and 32 females with an age mean ± SD of 46.68 ± 12.16 years and range of 15–70 years. Their genotypes were compared to 98 healthy controls of matched age and sex from the same locality. Genotyping was done through deoxyribonucleic acid amplification using PCR with sequence specific primers for polymorphic alleles.Results:Compared to controls, cases showed significant higher frequency of certain genotypes including IL-6-174 CC (P < 0.001, OR = 6.7), IL-10-1082 GG (P < 0.05, OR = 5.1), and TNF-α-308 GG (P < 0.05, OR = 3.7). TNF-α-308 GG and IL-10-1082 GG genotypes were higher among cases with plaque subtype of moderate severity. Combined heterozygosity for IL-10 GA, IL-6 GC with TNF GA showed a significant low frequency among studied cases.Conclusion:Genetic polymorphisms related to IL6, IL10, and TNF-α genes showed a particular pattern of association with psoriasis that may have a potential impact on disease counseling and management.

Inflammatory breast cancer: High incidence of GCC haplotypes (−1082A/G, −819T/C, and −592A/C) in the interleukin-10 gene promoter correlates with over-expression of interleukin-10 in patients’ carcinoma tissues

“…[54][55][56] Therefore, many genetic studies were conducted to investigate the correlation of IL-10 gene polymorphisms with various immune-mediated diseases. IL-10 -1082 A/G and its association with various diseases were the only studied SNP in Egyptian population such as psoriasis, 57 HBV, 58 Behcet's disease (BD), 59 and various types of tumors. 37,60 Haplotype frequencies are shown for each level of control and IBC group.…”

An investigation of the relationship between serotonin transporter gene promoter polymorphism and psoriasis susceptibility in a Thai population

“…Recently, it has been reported that certain genotypes of cytokine gene polymorphisms are more predominant in psoriatic cases with moderate severity (Settin et al, 2009). This particular finding suggests that certain genetic variations may be considered as severity-modifying polymorphisms with respect to psoriasis.…”

Associations between interleukin-10 polymorphisms and susceptibility to psoriasis: a meta-analysis

“…IL-10 is considered an attractive candidate gene based on its chromosomal location and functional relevance. A number of studies have examined the association between IL-10 polymorphisms and psoriasis, but reported results are contradictory [10][11][12][13][14][15][16][17], possibly because of the low statistical powers of individual studies. Therefore, in order to overcome the limitations of individual studies, resolve inconsistencies, and reduce the likelihood that random errors are responsible for false-positive or -negative associations [18][19][20], we turned to meta-analysis.…”