Association of decreased C1q/tumor necrosis factorrelated protein-5 levels with metabolic and hormonal disturbance in polycystic ovary syndrome

Abstract

Objective: C1q/tumor necrosis factor-related protein-5 (CTRP5) is a novel peptide hormone involved in the metabolism of energy regulation. Polycystic ovary syndrome (PCOS), which is a reproductive and metabolic disorder, is associated with insulin resistance. The aim of the current study was to compare circulating levels of CTRP5 in women with and without PCOS and to investigate possible associations between CTRP5 and metabolic-hormonal parameters. Material and Methods: The present cross-sectional study contained 80 women with PCOS and 80 age and body mass index-matched women without PCOS. Circulating levels of CTRP5 were calculated using an enzyme-linked immunosorbent assay. We also measured hormonal and metabolic parameters. Results: Patients with PCOS had lower levels of circulating CTRP5 compared with women without PCOS (6.90±2.64 vs 11.73±3.66 ng/mL, p<0.001). CTRP5 was negatively correlated with insulin resistance, free-androgen index, and body mass index in both the PCOS and control groups. Moreover, patients with PCOS who had insulin resistance showed lower circulating CTRP5 levels compared with those without insulin resistance. In both the control and PCOS groups, overweight subjects had lower circulating levels of CTRP5 compared with participants of normal weight. Logistic regression analyses indicated that subjects in the lowest tertile for CTRP5 level had higher risk for PCOS compared with those in the highest tertile of CTRP5. Conclusion: Decreased circulating levels of CTRP5 were associated with higher risk of PCOS, as well as having metabolic disturbance among women with PCOS.

Circulating levels of C1q/TNF‐α‐related protein 6 (CTRP6) in polycystic ovary syndrome

“…75 In the pathogenesis of PCOS, studies have shown a downregulation in adiponectin expression, 76 and lower levels of circulating CTRP3 and CTRP5. 22,23 Conversely, in the present study, we found that high serum levels of CTRP6 inversely correlated with metabolic disturbances in PCOS individuals, when compared with healthy controls, exhibiting a strong independent association with adiponectin. Low levels of adiponectin, CTRP3 and CTRP5 on one hand, and high levels of CTRP6 and CTRP15 on the other, have been witnessed in individuals diagnosed with insulin resistance, metabolic syndrome, and T2DM.…”

“…21 Moreover, circulating levels of CTRP3 and CTRP5 were also reported to be reduced in PCOS. 22,23 However, so far, there is no additional evidence on the role of other CTRPs in PCOS pathogenesis.…”

Circulating CTRP5 in rheumatoid arthritis: an exploratory biomarker study

“…For instance, an inverse correlation has been demonstrated between CTRP5 and TG in patients with type 2 diabetes and nonalcoholic fatty liver disease [ 27 ]. Furthermore, a weak negative correlation between CTRP5 and TG and a positive correlation with HDL-C was recently reported in women with polycystic ovary syndrome [ 28 ]. Whereas no correlation between circulating CTRP5 and HDL-C was detected, some shreds of evidence linked the upregulated CTRP5 to increased adipose tissue [ 29 , 30 ].…”

“…The expression of CTRP5 in children's adipocytes was directly correlated to the degree of obesity and their age [ 29 ]. Conversely, several investigations identified an inverse correlation between CTRP5 levels and BMI [ 27 , 28 ]. According to the present data, although BMI was significantly different between RA patients and healthy individuals, we observed a non-significant negative trend between circulating CTRP5 and BMI in RA patients.…”