Association of dietary patterns, anthropometric measurements, and metabolic parameters with C-reactive protein and neutrophil-to-lymphocyte ratio in middle-aged and older adults with metabolic syndrome in Taiwan: a cross-sectional study

Syauqy, Ahmad; Hsu, Chien Yeh; Rau, Hsiao Hsien; Chao, Jane C.-J.

doi:10.1186/s12937-018-0417-z

Cited by 39 publications

(39 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results demonstrate that increased adipose tissue appeared to affect MRT and MRV and resulted in thinning of the macula. NLR, PLR and SIII, which can be simply and inexpensively calculated from complete blood count, have been shown to indicate subclinical inflammation in several previous studies (8,31,32,33). Furuncuoglu et al (33) showed that NLR, PLR, and SIII are positively correlated with BMI in adults.…”

Section: Discussionmentioning

confidence: 95%

“…Furuncuoglu et al (33) showed that NLR, PLR, and SIII are positively correlated with BMI in adults. Another study of 26,016 adult patients determined positive correlation between NLR and MetS and obesity-related anthropometric data (32). One study of obese children with sleep apnea syndrome, a condition capable of leading to chronic hypoxia, showed that NLR and PLR increased with obesity (34).…”

Section: Discussionmentioning

confidence: 99%

“…Complete blood count is an inexpensive and easily accessible test. The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and systemic immuneinflammatory index (SIII), all of which are easily calculated from complete blood count, have been shown to indicate subclinical inflammation in several studies (8,9,10).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers

Öztürk¹,

Özen²,

Çatlı³

et al. 2020

Jcrpe

View full text Add to dashboard Cite

Macular damage may be observed in obesity and metabolic syndrome (MetS), a condition which leads to chronic subclinical inflammation and affects most organ systems. To investigate the association between macular variability and anthropometric measurements, metabolic parameters, and inflammatory markers in children and adolescents with MetS. Methods: Two hundred and twenty eyes of 62 obese and 48 healthy children and adolescents were examined. Bilateral macular retinal thickness (MRT) and macular retinal volume (MRV) were measured in all subjects using optical coherence tomography. Associations between mean MRT and mean MRV and age, auxological measurements including body mass index standard deviation scores (BMI-SDS) and waist circumference-SDS (WC-SDS), metabolic parameters and inflammatory parameters including neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio and systemic immune-inflammatory index (SIII) were investigated. Results: No statistically significant difference was observed between the groups in terms of age or sex distribution (p>0.05). Mean MRT (r=-0.326, p=0.007) and MRV (r=-0.303, p=0.007) values in the obese group with MetS decreased as homeostasis model assessmentinsulin resistance (HOMA-IR) values increased. SIII values were higher in obese groups, but particularly in obese subject with MetS, compared to the control group (p=0.021). The decrease in mean MRT (r=-0.544, p=0.046) and MRV (r=-0.651, p=0.031) in the obese subjects with MetS was negatively correlated with NLR. Mean MRT and MRV decreased in all obese subjects as SIII increased (p<0.05). Conclusion: This is the first study to show that mean MRT and MRV values decrease as BMI-SDS, WC-SDS and HOMA-IR increase in obese children and adolescents with MetS. NLR and SIII may serve as markers of chronic inflammation in obese children with MetS associated with macular damage.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers

Öztürk¹,

Özen²,

Çatlı³

et al. 2020

Jcrpe

View full text Add to dashboard Cite

show abstract

“…37 In addition, the western dietary pattern was revealed to be significantly associated with increased odds ratios of high CRP and NLR in both genders. 38 Monocytes play an important role in inflammation and atherosclerosis in MetS 39 and the production of inflammation cytokines. 40 The LMR has been recognized as a potentially predictive and prognostic maker for inflammation in distinct populations.…”

Section: Discussionmentioning

confidence: 99%

<p>Comparison of the Value of Neutrophil to High-Density Lipoprotein Cholesterol Ratio and Lymphocyte to High-Density Lipoprotein Cholesterol Ratio for Predicting Metabolic Syndrome Among a Population in the Southern Coast of China</p>

Chen¹,

Chen²,

Tang³

et al. 2020

DMSO

View full text Add to dashboard Cite

Background: This study aimed to determine the optimal cutoff values and evaluate the associations of neutrophil to high-density lipoprotein cholesterol ratio (NHR) and lymphocyte to high-density lipoprotein cholesterol ratio (LHR) with metabolic syndrome (MetS), stratified by sex. Methods: A large-scale cross-sectional survey was conducted among 1401 adults from January to April 2018 in six communities in Wanzhai Town, Zhuhai City, on the southern coast of China. Receiver operating characteristics (ROC) analyses and logistic regression analysis were conducted to assess the optimal cutoff and value of NHR and LHR for predicting MetS. Results: Hematological parameters showed the correlation with the occurrence of MetS (red blood cells, hemoglobin, and white blood cells and subtypes). Binomial logistic regression analysis found that LHR (OR: 3.671; 95% CI: 2.385-5.651; p<0.001) and NHR (OR: 1.728; 95% CI: 1.353-2.207; p<0.001) can predict MetS in females, independent of confounding factors. Although LHR (OR: 1.571; 95% CI: 1.001-2.468; p=0.05) and NHR (OR: 1.163; 95% CI: 0.909-1.48; p<0.01) were independent risk factors for MetS in males after adjustment for age, current smoking, current alcohol use, physical activity, educational attainment, waist circumference, systolic pressure, diastolic pressure and hypersensitive C-reactive protein (hs-CRP), when further adjusted for fasting plasma glucose level, LHR and NHR, both lost their independence. ROC curves showed that LHR had the highest AUC for predicting MetS in females and NHR had the highest AUC in males. The cutoff points of LHR and NHR were 1.36 and 2.31 in females, and 1.96 and 3.38 in males. Conclusion: LHR and NHR may become valuable makers and have strong predictive power for predicting MetS, especially in females.

show abstract

“…Moreover, multiple studies have focused on assessing the role of NLR and PLR in patients with related-comorbidities; a study performed with 155 obese and non-obese patients with obstructive sleep apnea found significantly higher values in terms of NLR among obese individuals (46). Metabolic syndrome related obesity is another disorder commonly associated with chronic inflammation that was found to be related with NLR (48). Nevertheless, the findings remain contradictory because similar to our study, Bahadir et al also failed to prove an association between NLR and obesity or metabolic syndrome (49).…”

Section: Discussionmentioning

confidence: 99%

Early Inflammatory Status Related to Pediatric Obesity

et al. 2019

View full text Add to dashboard Cite

Background: Obese individuals are often in a chronic inflammatory condition due to the malfunction of immune-related activities in the adipose tissue, involving a transient infiltration of neutrophils within the abdominal fat and their binding to adipocytes. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are considered cost-effective markers for the detection of subclinical inflammation. Our study intends to assess the early stages of inflammation associated with overweight and obesity in children. Materials and Methods: We performed a prospective study with 164 children, aged between 5 and 18 years, admitted to a Pediatric Tertiary Hospital in Romania between January 2018 and January 2019. The patients were divided according to body mass index (BMI) into two groups: Group 1: 77 overweight and obese children (BMI percentile ≥85), and Group 2: 87 children with a normal BMI, in order to evaluate the correlation between BMI and laboratory parameters (CBC, ESR, transaminase, total protein, albumin, and blood glucose levels), inflammatory biomarkers, NLR and PLR, and changes in abdominal ultrasound findings. Results: We found that the leukocyte, lymphocyte, erythrocyte, platelet, CRP, and transaminase levels were significantly higher in the overweight/obese group ( p = 0.0379, p = 0.0002, p = 0.0003, p = 0.0006, p < 0.0001, p = 0.0332, and p < 0.0001, respectively). No significant statistical differences between the two groups in terms of neutrophil, hemoglobin, albumin, total protein, and glycemia levels were noted ( p > 0.05). Moreover, NLR and PLR did not differ significantly between the two groups ( p = 0.4674 and p = 0.9973, respectively). Conclusions: Obesity is associated with systemic low-grade inflammation which is reaching alarming rates worldwide among both children and adults. Our study proved that leukocyte, lymphocyte, erythrocyte, and platelet levels are significantly higher in overweight/obese children, emphasizing the inflammatory status related to this condition. Therefore, obesity-related studies involving pediatric patients are of major interest in order to develop appropriate methods to prevent the development of further complications in adulthood.

show abstract

Association of dietary patterns, anthropometric measurements, and metabolic parameters with C-reactive protein and neutrophil-to-lymphocyte ratio in middle-aged and older adults with metabolic syndrome in Taiwan: a cross-sectional study

Cited by 39 publications

References 55 publications

Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers

Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers

<p>Comparison of the Value of Neutrophil to High-Density Lipoprotein Cholesterol Ratio and Lymphocyte to High-Density Lipoprotein Cholesterol Ratio for Predicting Metabolic Syndrome Among a Population in the Southern Coast of China</p>

Early Inflammatory Status Related to Pediatric Obesity

Contact Info

Product

Resources

About