<p>Comparison of the Value of Neutrophil to High-Density Lipoprotein Cholesterol Ratio and Lymphocyte to High-Density Lipoprotein Cholesterol Ratio for Predicting Metabolic Syndrome Among a Population in the Southern Coast of China</p>

Abstract

Background: This study aimed to determine the optimal cutoff values and evaluate the associations of neutrophil to high-density lipoprotein cholesterol ratio (NHR) and lymphocyte to high-density lipoprotein cholesterol ratio (LHR) with metabolic syndrome (MetS), stratified by sex. Methods: A large-scale cross-sectional survey was conducted among 1401 adults from January to April 2018 in six communities in Wanzhai Town, Zhuhai City, on the southern coast of China. Receiver operating characteristics (ROC) analyses and logistic regression analysis were conducted to assess the optimal cutoff and value of NHR and LHR for predicting MetS. Results: Hematological parameters showed the correlation with the occurrence of MetS (red blood cells, hemoglobin, and white blood cells and subtypes). Binomial logistic regression analysis found that LHR (OR: 3.671; 95% CI: 2.385-5.651; p<0.001) and NHR (OR: 1.728; 95% CI: 1.353-2.207; p<0.001) can predict MetS in females, independent of confounding factors. Although LHR (OR: 1.571; 95% CI: 1.001-2.468; p=0.05) and NHR (OR: 1.163; 95% CI: 0.909-1.48; p<0.01) were independent risk factors for MetS in males after adjustment for age, current smoking, current alcohol use, physical activity, educational attainment, waist circumference, systolic pressure, diastolic pressure and hypersensitive C-reactive protein (hs-CRP), when further adjusted for fasting plasma glucose level, LHR and NHR, both lost their independence. ROC curves showed that LHR had the highest AUC for predicting MetS in females and NHR had the highest AUC in males. The cutoff points of LHR and NHR were 1.36 and 2.31 in females, and 1.96 and 3.38 in males. Conclusion: LHR and NHR may become valuable makers and have strong predictive power for predicting MetS, especially in females.

Lymphocyte to High-Density Lipoprotein Ratio but Not Platelet to Lymphocyte Ratio Effectively Predicts Metabolic Syndrome Among Subjects From Rural China

“…They also concluded that LHR may be a useful marker of inflammation to assess the presence and severity of MetS (16). Similarly, Tong Chen and colleagues revealed that both LHR (OR: 3.671) and neutrophil to high-density lipoprotein cholesterol ratio (NHR) (OR: 1.728) can predict MetS in females only independent of associated risk factors (17). In consistent with previous studies, data from our study also found that increasing value of LHR was correlated with higher risk of MetS.…”

“…Hemogram parameters, like lymphocyte, platelet count, and biochemical indexes, like HDL-C, LDL-C, were reported to be markers of inflammation. Lymphocyte to high-density lipoprotein cholesterol ratio (LHR) and platelet to lymphocyte ratio (PLR), as a novel inflammatory marker, were proved to be associated with many cardiovascular risk factors (13)(14)(15)(16)(17). To the best of our knowledge, there was no studies aiming to assess the possible predictive effect of LHR and PLR on newly diagnosed MetS among rural subjects from Northeast China.…”

Relationship between neutrophils to HDL-C ratio and severity of coronary stenosis

“…Furthermore, as regards the complex interaction between neutrophils and HDL-C, a comprehensive indicator of NHR may be more effective and reliable than a single indicator. In previous studies, NHR was calculated as a simple ratio of neutrophils and HDL-C, and related reports have assessed them as predictive markers of metabolic syndrome [ 23 ]. Another study showed a correlation between NHR and the extent of coronary artery disease [ 24 ].…”

Serum 25-Hydroxyvitamin D Is Inversely Associated with Monocyte Percentage to HDL Cholesterol Ratio among Young Healthy Adults in Qatar

“…Recent studies investigated whether lymphocytes and neutrophils as predictors of inflammation. LHR and NHR along with MHR were good predictive biomarkers of inflammatory diseases such as metabolic syndrome [ 55 , 56 ]. In our study, we found no association between serum 25(OH)D and LHR and NHR.…”