Lymphocyte to High-Density Lipoprotein Ratio but Not Platelet to Lymphocyte Ratio Effectively Predicts Metabolic Syndrome Among Subjects From Rural China

Abstract

Background: This study intended to use two novel inflammatory indicators: lymphocyte to high-density lipoprotein cholesterol ratio (LHR) and platelet to lymphocyte ratio (PLR), to predict newly diagnosed metabolic syndrome (MetS) among subjects from rural Northeast China.Methods: Adult participants without MetS at baseline (n = 4,980, age = 52.65 ± 10.21 years; 51.9% men) were originated from the Northeast China Rural Cardiovascular Health Study (NCRCHS). LHR (Q1: ≤1.04; Q2: 1.04–1.35; Q3: 1.35–1.79; Q4: ≥1.79) and PLR (Q1: ≤78.50; Q2: 78.50–107.27; Q3: 107.27–140.00; Q4: ≥140.00) were divided in quartile.Results: After 4.66-year follow-up, 1,194 subjects were diagnosed MetS (cumulative incidence 24.0; 25.8% for female and 22.3% for male, P = 0.002). Newly diagnosed MetS had higher value of hemoglobin and platelet count compared to those without MetS. As for LHR, from Q1 to Q4, there were increasing value of waist circumference (WC), serum triglycerides (TG), rates of current smoking and drinking whereas decreasing value of HDL-C. However, for PLR, rates of current smoking and drinking significantly decreased from Q1 to Q4. Similarly, the value of WC and TG showed a decreasing trend. In a logistic regression analysis, after adjusted for possible confounders, LHR [OR (95% CI) Q2: 1.13 (0.86, 1.48); OR (95% CI) Q3: 1.23 (0.94, 1.61); OR (95% CI) Q4: 1.57(1.20, 2.06)] but not PLR was effective predictor of newly diagnosed MetS among rural Chinese.Conclusion: MetS had closed relationship with inflammation among subjects from rural China. As a novel marker of inflammation, LHR but not PLR might be an effective predictor of newly diagnosed MetS and should be widely used in the epidemiological study.

MHR and NHR but not LHR were associated with coronary artery disease in patients with chest pain with controlled LDL-C

“…LHR was proposed by Chen et al 12 as a novel inflammatory indicator. Consistent with the results from Chen et al ,12 other studies have confirmed the role of LHR in predicting the presence and severity of metabolic syndrome 20 21. Considering the close relationship between metabolic syndrome and atherosclerosis, it is reasonable to wonder on the effect of LHR on the development of CAD.…”

Combination model of neutrophil to high-density lipoprotein ratio and system inflammation response index is more valuable for predicting peripheral arterial disease in type 2 diabetic patients: A cross-sectional study

“…Obtaining the numbers of neutrophils, monocytes, lymphocytes, and platelets is inexpensive and easy via complete blood count, which are altered when an organism is inflamed. Furthermore, new hematological parameters related to HDL-C and complete blood cells, such as NHR ( 8 ), MHR ( 9 ), LHR ( 10 ), PHR ( 11 ), SII ( 12 ), SIRI ( 13 , 14 ), and AISI ( 15 ) have been proposed as novel inflammatory biomarkers.…”

The association between lymphocyte to high‐density lipoprotein ratio and depression: Data from NHANES 2015–2018

“…LHR could act as an index of inflammatory status according to previous studies (H. Chen et al, 2019;T. Chen et al, 2020;Yu et al, 2021).…”

“…LHR: lymphocyte to high-density lipoprotein ratio; BMI: body mass index. 2020) that can predict the occurrence and severity of MetS (Yu et al, 2021). Cytokines and proteolytic enzymes induced by chronic inflammation, insulin, and insulin growth factors, I and II may explain the association between LHR and MetS (Lao et al, 2008;Pasini et al, 2010;Tamariz et al, 2008).…”