Association of dietary tomato intake with bladder cancer risk in a prospective cohort of 101,683 individuals with 12.5 years of follow-up

Xu, Xin; Xie, Bo; Li, Shiqi; Wang, Shuo; Xia, Dan; Meng, Hua

doi:10.18632/aging.203252

Cited by 3 publications

(6 citation statements)

References 27 publications

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“…To our knowledge this is the first study to report a protective effect of tomato salsa against CRC risk. In contrast, a previous study did not observe a significant association between bladder cancer risk and tomato salsa consumption after adjustment for confounders in the PLCO cohort (29). These results suggest that the protective effect of tomato salsa against cancer risk is heterogenous among different cancers.…”

Section: Discussioncontrasting

confidence: 94%

“…Although intake of tomato and/or lycopene has been associated with reduced risk of several cancers such as hepatocellular carcinoma (13), prostate cancer (14), pancreatic cancer (15), gastric cancer (16), ovarian cancer (17), and CRC (18,19), in this large PLCO study CRC risk was not significantly associated with consumption of raw tomato, tomato juice, or tomato catsup. That was consistent with a previous study investigating bladder cancer (29), but inconsistent with a previous case-control study conducted in a CRC population in Italy, in which there was a protective association between a higher intake of tomato and the incidence of CRC (18), and sub-sites of CRC stratified by cancer site (19). These differences may be due to the retrospective nature of the previous studies on this topic, which only examined associations with total tomato intake.…”

Section: Discussionsupporting

confidence: 72%

“…These differences may be due to the retrospective nature of the previous studies on this topic, which only examined associations with total tomato intake. The current study investigated the effects of specific types of tomato products (i.e., raw tomato and tomato catsup) on the incidence of CRC, which may have differential effects on health outcomes (29). Similarly, selection and recall bias due to the retrospective designs and residual confounders in previous studies may also have led the inconsistent results.…”

Section: Discussionmentioning

confidence: 99%

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Associations between colorectal cancer risk and dietary intake of tomato, tomato products, and lycopene: evidence from a prospective study of 101,680 US adults

Jiang,

Chen,

et al. 2023

Front. Oncol.

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BackgroundPrevious epidemiological studies have yielded inconsistent results regarding the effects of dietary tomato, tomato products, and lycopene on the incidence of colorectal cancer (CRC), possibly due to variations in sample sizes and study designs.MethodsThe current study used multivariable Cox regression, subgroup analyses, and restricted cubic spline functions to investigate correlations between CRC incidence and mortality and raw tomato, tomato salsa, tomato juice, tomato catsup, and lycopene intake, as well as effect modifiers and nonlinear dose-response relationships in 101,680 US adults from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.ResultsDuring follow-up 1100 CRC cases and 443 CRC-specific deaths occurred. After adjustment for confounding variables, high consumption of tomato salsa was significantly associated with a reduced risk of CRC incidence (hazard ratio comparing the highest category with the lowest category 0.8, 95% confidence interval 0.65–0.99, p for trend = 0.039), but not with a reduced risk of CRC mortality. Raw tomatoes, tomato juice, tomato catsup, and lycopene consumption were not significantly associated with CRC incidence or CRC mortality. No potential effect modifiers or nonlinear associations were detected, indicating the robustness of the results.ConclusionIn the general US population a higher intake of tomato salsa is associated with a lower CRC incidence, suggesting that tomato salsa consumption has beneficial effects in terms of cancer prevention, but caution is warranted when interpreting these findings. Further prospective studies are needed to evaluate its potential effects in other populations.

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Section: Discussioncontrasting

confidence: 94%

Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

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Associations between colorectal cancer risk and dietary intake of tomato, tomato products, and lycopene: evidence from a prospective study of 101,680 US adults

Jiang,

Chen,

et al. 2023

Front. Oncol.

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“…[ 37 ] However, in the meta‐analysis for tomato consumption and prostate cancer in the Western population, dietary tomato consumption was not associated with the risk of prostate cancer, [ 38 ] and tomato consumption was not significantly related to the risk of bladder cancer. [ 39 ]…”

Section: Discussionmentioning

confidence: 99%

“…[37] However, in the meta-analysis for tomato consumption and prostate cancer in the Western population, dietary tomato consumption was not associated with the risk of prostate cancer, [38] and tomato consumption was not significantly related to the risk of bladder cancer. [39] Previous studies with the cohort of the US National Health and Nutrition Examination Survey (NHANES) and Prostate, Lung, Colorectal, and Ovarian screening trial reported an inverse asso-ciation of tomato and lycopene consumption with risk of all-cause and CVD mortality. [21,23] These findings for tomato and lycopene consumption and CVD mortality were consistent with our results.…”

Section: Discussionmentioning

confidence: 99%

Association between Tomato and Lycopene Consumption and Risk of All‐Cause and Cause‐Specific Mortality: Korean Genome and Epidemiology Study Cohort

Jung

Shin

2023

Molecular Nutrition Food Res

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Scope Tomato has well‐known beneficial health effects and is an important source of lycopene. The study aims to clarify the evidence for the association between tomato and lycopene consumption and all‐cause and cause‐specific mortality in Korean adults. Methods and results Data analyzed in the current study are obtained from the Korean Genome and Epidemiology Study Cohort. Mortality outcomes are determined based on death records from 2001 to 2020. Tomato and lycopene consumption is assessed using food frequency questionnaires and antioxidant databases and divided into quintiles. Over a mean follow‐up of 11.5 years, 5863 deaths are recorded among 139913 participants aged over 40 years. Tomato consumption is not associated with the risk of all‐cause and cancer mortality. However, the highest tomato consumption group has a lower risk of cardiovascular disease (CVD) mortality (HR = 0.779; 95% CI = 0.633, 0.957). Lycopene consumption is inversely associated with all‐cause (HR = 0.872; 95% CI = 0.801, 0.950), and CVD (HR = 0.680; 95% CI = 0.548, 0.845) mortality. Conclusion A higher intake of tomatoes and lycopene is inversely related to the risk of CVD mortality, and lycopene consumption is associated with a lower risk of all‐cause mortality.

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J-Shaped Association of Tomato Intake with New-Onset Hypertension in General Adults: A Nationwide Prospective Cohort Study

Zhao

Tian

et al. 2022

Nutrients

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We aim to examine the prospective association between the intake of dietary tomatoes and the risk of new-onset hypertension and its modifiable factors in general adults. A total of 11,460 adults without hypertension from the China Health and Nutrition Survey (CHNS) were enrolled, with follow-up beginning in 1997 and ending in 2015. Dietary tomato intake was measured by three consecutive 24-h dietary recalls combined with a household food inventory. The study outcome was new-onset hypertension, defined as systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg or diagnosed by physicians or under anti-hypertensive treatment during the follow-up. Finally, 4015 subjects developed new-onset hypertension during 92,335.5 person-years of follow-up. After multivariate adjustment for dietary and non-dietary risk factors, hazard ratios for increased consumption of dietary tomatoes were 0.42 (95% confidence interval, 0.37–0.47), 0.51 (0.46–0.57), and 0.82 (0.74–0.92) compared with non-consumers. Overall, cubic spline regression suggested a novel J-shaped association between dietary tomato intake and new-onset hypertension, with the lowest risk observed at approximately 10 to 13 g/day (p < 0.001 for curvature). Moreover, the association between dietary tomato intake and risk of new-onset hypertension was stronger in females or individuals who refrained from smoking or drinking (p = 0.024, p = 0.043, and p = 0.044 for interaction, respectively).

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Association of dietary tomato intake with bladder cancer risk in a prospective cohort of 101,683 individuals with 12.5 years of follow-up

Cited by 3 publications

References 27 publications

Associations between colorectal cancer risk and dietary intake of tomato, tomato products, and lycopene: evidence from a prospective study of 101,680 US adults

Associations between colorectal cancer risk and dietary intake of tomato, tomato products, and lycopene: evidence from a prospective study of 101,680 US adults

Association between Tomato and Lycopene Consumption and Risk of All‐Cause and Cause‐Specific Mortality: Korean Genome and Epidemiology Study Cohort

J-Shaped Association of Tomato Intake with New-Onset Hypertension in General Adults: A Nationwide Prospective Cohort Study

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