Association of different HLA antigens with various toxic effects of gold salts in rheumatoid arthritis.

Hakala, M; Assendelft, A H van; Ilonen, Jorma; Jalava, S; Tiilikainen, A

doi:10.1136/ard.45.3.177

Cited by 47 publications

(9 citation statements)

References 28 publications

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“…Apart from these drugs, gold was probably the most common agent recognized as initiating an LP-like eruption (Penneys et al, 1974). Gold salts can cause a range of mucocutaneous lesions (Hakala et al, 1986), of which oral lichenoid lesions may be the first (Brown et al, 1993;Laeijendecker and Van loost, 1994).…”

Section: (3) Drugsmentioning

confidence: 99%

Update On Oral Lichen Planus: Etiopathogenesis and Management

Scully

Beyli²,

Ferreiro

et al. 1998

Critical Reviews in Oral Biology & Medicine

476

461

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Lichen planus (LP) is a relatively common disorder of the stratified squamous epithelia, which is, in many ways, an enigma. This paper is the consensus outcome of a workshop held in Switzerland in 1995, involving a selection of clinicians and scientists with an interest in the condition and its management. The oral (OLP) eruptions usually have a distinct clinical morphology and characteristic distribution, but OLP may also present a confusing array of patterns and forms, and other disorders may clinically simulate OLP. Lesions may affect other mucosae and/or skin. Lichen planus is probably of multifactorial origin, sometimes induced by drugs or dental materials, often idiopathic, and with an immunopathogenesis involving T-cells in particular. The etiopathogenesis appears to be complex, with interactions between and among genetic, environmental, and lifestyle factors, but much has now been clarified about the mechanisms involved, and interesting new associations, such as with liver disease, have emerged. The management of lichen planus is still not totally satisfactory, and there is as yet no definitive treatment, but there have been advances in the control of the condition. There is no curative treatment available; immunomodulation, however, can control the condition. Based on the observed increased risk of malignant development, OLP patients should be offered regular follow-up examination from two to four times annually and asked to report any changes in their lesions and/or symptoms. Follow-up may be particularly important in patients with atrophic/ulcerative/erosive affections of the tongue, the gingiva, or the buccal mucosa. Much more research is required into the genetic and environmental aspects of lichen planus, into the premalignant potential, and into the possible associations with chronic liver, and other, disorders. More clinical studies are required into the possible efficacy of immunomodulatory drugs such as pentoxifylline and thalidomide.

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Section: (3) Drugsmentioning

confidence: 99%

Update On Oral Lichen Planus: Etiopathogenesis and Management

Scully

Beyli²,

Ferreiro

et al. 1998

Critical Reviews in Oral Biology & Medicine

476

461

View full text Add to dashboard Cite

show abstract

“…Apart from these drugs, gold was probably the most common agent recognized as initiating a lichenoid reaction (Penneys et al, 1974). Gold salts can cause a range of mucocutaneous lesions (Hakala et al, 1986) of which oral lichenoid lesions may be the first (Brown et al, 1993;Laeijendecker and van Joost, 1994).…”

Section: (2) Drug-related White Lesions (A) Burns (See Above) (B) Licmentioning

confidence: 99%

Adverse Drug Reactions in the Orofacial Region

Scully

Bagán

2004

Critical Reviews in Oral Biology & Medicine

215

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A wide spectrum of drugs can sometimes give rise to numerous adverse orofacial manifestations, particularly dry mouth, taste disturbances, oral mucosal ulceration, and/or gingival swelling. There are few relevant randomized double-blind controlled studies in this field, and therefore this paper reviews the data from case reports, small series, and non-peer-reviewed reports of adverse drug reactions affecting the orofacial region (available from a MEDLINE search to April, 2003). The more common and significant adverse orofacial consequences of drug therapy are discussed.

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“…HAKALA et al [52] showed that gold-induced hypersensitivity pneumonitis is associated with HLA-DR1 in Finnish RA patients and the same association was found by PAR-TANEN et al [53]. Strikingly, in RA patients with gold hypersensitivity described by ROMAGNOLI et al [92], the T-cell response to gold was restricted by HLA-DR1, leading to the hypothesis that gold may be able to haptenize, or "neoantigenize", the HLA-DR1 molecule.…”

Section: Hypersensitivity Pneumonitismentioning

confidence: 83%

Immunogenetic basis of environmental lung disease: lessons from the berylliosis model

Saltini¹,

Amicosante²,

Franchi³

et al. 1998

Eur Respir J

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The role of genetic factors has been hypothesized in the pathogenesis of a number of chronic inflammatory lung diseases. The genes of the major histocompatibility complex (MHC) locus on human chromosome 6 have been identified as important determinants in diseases caused both by inorganic and organic compounds such as beryllium, gold, acid anhydrides, isocyanates and grass pollens. Since many environmental factors are the determinants of the immunopathogenesis of asthma, pulmonary granulomatous disorders, hypersensitivity pneumonitis and fibrotic lung disorders, an understanding of the interaction between environmental factors is crucial to epidemiology, prevention and treatment of these disorders. Berylliosis is an environmental chronic inflammatory disorder of the lung caused by inhalation of beryllium dusts. A human leukocyte antigen class II marker (HLA-DP Glu69) has been found to be strongly associated with the disease. In in vitro studies, the gene has been shown to play a direct role in the immunopathogenesis of the disease. In human studies, the gene has been shown to confer increased susceptibility to beryllium in exposed workers, thus suggesting that HLA gene markers may be used as epidemiological probes to identify population groups at higher risk of environmental lung diseases, to identify environmental levels of lung immunotoxicants that would be safe for the entire population and to prevent disease risk associated with occupation, manufactured products and the environment. Studies on the associations between human leukocyte antigens and chronic inflammatory lung disorders are reviewed in the context of the berylliosis model.

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Association of different HLA antigens with various toxic effects of gold salts in rheumatoid arthritis.

Cited by 47 publications

References 28 publications

Update On Oral Lichen Planus: Etiopathogenesis and Management

Update On Oral Lichen Planus: Etiopathogenesis and Management

Adverse Drug Reactions in the Orofacial Region

Immunogenetic basis of environmental lung disease: lessons from the berylliosis model

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