Association Of Dog Exposure and Early-Life IgE Production In The Microbes, Asthma, Allergy and Pets (MAAP) Birth Cohort

Abstract

Research on the influence of different architectural styles and ventilation systems on mite allergen levels is crucial to decrease mite allergen exposures in houses. The purpose of this study was to examine the seasonal changes in mite allergen (Der 1) levels on the floors and mattresses of houses with different architectural styles and ventilation systems. METHODS: Thirty-one families, without considering the families' histories of allergies, participated in this study. Written consent was obtained from all the families. All 31 families lived in Hamamatsu-city, Japan. Dust samples were monthly collected from the floors of the living rooms and mattresses in the bedrooms from March 2019 to February 2020. Mite allergen Der 1 (Der f 1 and Der p 1) levels were measured using sandwich ELISA. The air temperature and relative humidity in each house were measured using hygrothermography. RESULTS: Ten families lived in detached houses with balanced ventilation (group A), 10 families lived in detached houses with exhaustonly ventilation (group B), and 11 families lived in concrete apartment buildings with exhaust-only ventilation (group C). All groups showed significant seasonal changes in mean monthly temperature and relative humidity. Group A showed significantly lower mean monthly relative humidity than other groups. Group A showed significantly lower levels of Der 1 in mattress dust than other groups. CONCLUSIONS: Different architectural styles and ventilation systems may have some influence on mite allergen levels and could possibly be modified to decrease mite allergen exposure in houses.

Heritable vaginal bacteria influence immune tolerance and relate to early-life markers of allergic sensitization in infancy

“…Infant serum total IgE levels were generated within the WISC 52 and MAAP 60 studies as previously described. Specific IgE for foods was available from WISC participants (milk, egg, peanut).…”