Association of elevated triglycerides and acute myocardial infarction in young Hispanics

Essilfie, Gilbert; Shavelle, David M.; Tun, Han; Platt, Kevin D.; Kobayashi, Ryan; Mehra, Anilkumar; Matthews, Ray V.; Clavijo, Leonardo; Gaglia, Michael A.

doi:10.1016/j.carrev.2016.06.001

Cited by 10 publications

(9 citation statements)

References 29 publications

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“…The global incidence of MI was 2483 per 100,000 in 2016 [2], and MI accounts for about one million deaths in China annually [3]. Previous investigations revealed that dyslipidemias has a major and causal role in MI development, and that MI incidence increases with high total cholesterol (TC) levels, high low-density https://doi.org/10.1016/j.atherosclerosis.2020.03.026 Received 6 November 2019; Received in revised form 22 February 2020; Accepted 27 March 2020 lipoprotein cholesterol (LDL-C) levels, high triglyceride (TG) levels, high non-high-density lipoprotein cholesterol (non-HDL-C) levels, and low high-density lipoprotein cholesterol (HDL-C) levels [4][5][6][7][8][9]. However, recent studies [10,11] have indicated that lipid level evaluation at a single time point may yield a biased estimate of the relationships between lipid levels and MI risk, and that changes in lipids may be an important factor for accurate prediction of MI risk.…”

Section: Introductionmentioning

confidence: 99%

“…These findings raise the question as to whether changes in lipid levels are associated with risk of MI in people without lipid-lowering therapy. Because the majority of previous studies [4][5][6][7][8][9] focused on baseline lipid levels and risk of MI, evidence on the effects of changes in lipid levels on MI incidence in participants without lipid-lowering therapy remains insufficient.…”

Section: Introductionmentioning

confidence: 99%

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Association of changes in lipids with risk of myocardial infarction among people without lipid-lowering therapy

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of changes in lipids with risk of myocardial infarction among people without lipid-lowering therapy

et al. 2020

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“…Therefore, other novel risk factors should be evaluated in these young patients. It has been reported that plasma homocysteine, γ-glutamyl transferase, triglycerides, lipoprotein subfractions and fibrinogen may be associated with an increased risk of CAD in young patients 7 – 11 , and most of these may be mediated by vascular inflammation.…”

Section: Introductionmentioning

confidence: 99%

Lipoprotein-associated phospholipase A2 and oxidized low-density lipoprotein in young patients with acute coronary syndrome in China

Huang

Yang

et al. 2017

Sci Rep

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Lipoprotein-associated phospholipase A2 (Lp-PLA2) is considered to be a risk factor for acute coronary syndrome (ACS), but this remains controversial. This study investigated the role of Lp-PLA2 in young Chinese patients with ACS. 228 young patients (aged ≤55 years) with ACS and 237 age-matched controls were included. Lp-PLA2 and oxidized low-density lipoprotein (ox-LDL) levels were measured by sandwich enzyme-linked immunosorbent assay. Lp-PLA2 levels were significantly correlated with smoking, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and ox-LDL levels (all P < 0.05). Multivariate logistic regression analysis showed that male sex (OR = 3.25, 95%CI = 1.26–8.38), smoking (OR = 3.50, 95%CI = 1.75–7.0), triglyceride (OR = 1.76, 95%CI = 1.08–2.87), high sensitivity C-reactive protein (hs-CRP) (OR = 2.11, 95%CI = 1.14–3.90) and ox-LDL (OR = 2.98, 95%CI = 1.72–5.1) were independently associated with ACS risk in young patients. Lp-PLA2 was associated with risk of ACS in young patients when adjusted for traditional risk factors, including age, sex, diabetes, hypertension, smoking, TC, LDL-C, triglyceride and hs-CRP (OR = 1.98, 95%CI = 1.10–3.56). When further adjusted for ox-LDL levels, the association between Lp-PLA2 and ACS became insignificant (OR = 1.69, 95%CI = 0.90–3.17). Lp-PLA2 was a marker of oxidative stress and inflammation, rather than an independent risk factor for ACS in young Chinese patients.

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“…Among Hispanic adults currently living in the US, 51% of males and 41% of females have elevated blood pressure (Virani et al, 2021). One study found that Hispanics under age 45 had a higher incidence of MetS than older Hispanics (Essilfie et al, 2016). This could signify the less healthy lifestyles of Hispanics born in the US compared to those who immigrate to the US.…”

Section: Introductionmentioning

confidence: 99%

Electrocardiogram Abnormalities Associated With Metabolic Syndrome: The Hispanic Community Health Study/Study of Latinos

Richard

Kim

et al. 2023

Biological Research For Nursing

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Background Metabolic syndrome (MetS) is a prognostic cluster of physiologic risk factors that may develop into cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). Electrocardiogram abnormalities (ECGA) can be instrumental in identifying the early stages of disease and may be associated with MetS in Hispanic Americans. Objective To explore the relationships between MetS and major and minor ECGA in the Hispanic population (Hypothesis 1) and determine whether gender-ethnic subgroups moderate these relationships (Hypothesis 2). Methods This secondary data analysis was conducted using large-scale data from the cohort study Hispanic Community Health Study/Study of Latinos ( N = 13,628; 59% women and 41% men). Major ECGA encompassed 9 abnormalities including pathologic Q waves and left ventricular hypertrophy. Minor ECGA were tested independently of major ECGA. MetS was classified into 4 categories delineating metabolic abnormalities and related medication use. Multinomial logistic regression and Hayes’ PROCESS macro were used for statistical analysis. Results Major ECGA were significantly associated with the presence of MetS and/or related medication use, whereas minor ECGA abnormalities were associated with MetS for participants who also took MetS-related medications only. Gender moderated the association between MetS and minor ECGA such that women with minor ECGA had a higher likelihood of MetS when compared to men. Conclusions Findings suggest that early recognition and associated treatment of major and minor ECGA can be important to prevent MetS and further morbidities in the Hispanic population.

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Association of elevated triglycerides and acute myocardial infarction in young Hispanics

Cited by 10 publications

References 29 publications

Association of changes in lipids with risk of myocardial infarction among people without lipid-lowering therapy

Association of changes in lipids with risk of myocardial infarction among people without lipid-lowering therapy

Lipoprotein-associated phospholipase A2 and oxidized low-density lipoprotein in young patients with acute coronary syndrome in China

Electrocardiogram Abnormalities Associated With Metabolic Syndrome: The Hispanic Community Health Study/Study of Latinos

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