Association of Environmental Factors with Age-Related Macular Degeneration using the Intelligent Research in Sight Registry

Hunt, M. L.; Chee, Yewlin E.; Saraf, Steven S.; Chew, Emily Y.; Lee, Cecilia S.; Lee, Aaron; Manookin, Michael B.

doi:10.1016/j.xops.2022.100195

Cited by 6 publications

(10 citation statements)

References 23 publications

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“…After screening titles and abstracts combined with necessary full-text review, eight studies with 15,029,888 individuals were eligible for further analysis. Among these, four studies analysed PM 2.5 [8,[13][14][15], and three examined NO 2 [7,13,16] or O 3 [16][17][18]. Two of the eight studies were longitudinal cohort studies [7,8], while the rest were cross-sectional studies [13][14][15][16][17][18].…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…Among these, four studies analysed PM 2.5 [8,[13][14][15], and three examined NO 2 [7,13,16] or O 3 [16][17][18]. Two of the eight studies were longitudinal cohort studies [7,8], while the rest were cross-sectional studies [13][14][15][16][17][18]. In the longitudinal cohort study that explored the association between the AMD risk and CO or NO 2 , 1,442 individuals among 39,819 AMD-free residents developed AMD during the study period of 11 years [7].…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…The assessment and definition of AMD varied among studies. Among six studies applying standardised criteria for AMD diagnosis, grading was performed by at least two independent ophthalmologists to ensure the accuracy of diagnosis in three studies [8,16,17], whereas the other three did not describe the specific grading methodology [7,14,18]. Different from the standardised criteria, cases were diagnosed based on medical record review or self-reporting in two studies [13,15].…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…One study assessed AMD in patients with and without visual impairment [15]. One study explored the relationship of air pollution exposure with exudative and non-exudative AMD [18].…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

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Association between ambient air pollution and age-related macular degeneration: a meta-analysis

Wu,

Zhang,

2024

BMC Ophthalmol

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Background Several epidemiological studies have investigated the association between ambient air pollution and age-related macular degeneration (AMD). However, a consensus has not yet been reached. Our meta-analysis aimed to clarify this association. Methods Databases, including PubMed, EMBASE, and Web of Science, were searched for relevant studies from 01 January 2000 to 30 January 2024. English-language, peer-reviewed studies using cross-sectional, prospective, or retrospective cohorts and case–control studies exploring this relationship were included. Two authors independently extracted data and assessed study quality. A random-effects model was used to calculate pooled covariate-adjusted odds ratios. Heterogeneity across studies was also tested. Results We identified 358 relevant studies, of which eight were included in the meta-analysis. Four studies evaluated the association between particulate matter less than 2.5 μm in diameter (PM2.5) and AMD, and three studies explored the relationship between nitrogen dioxide (NO2) or ozone (O3) and AMD. The pooled odds ratios were 1.16 (95% confidence interval [CI]: 1.11–1.21), 1.17 (95% CI: 1.09–1.25), and 1.06 (95% CI: 1.05–1.07), respectively. Conclusion Current evidence suggests a concomitant positive but not causal relationship between PM2.5, NO2, or O3 and AMD risk.

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Section: Study Selection and Characteristicsmentioning

confidence: 99%

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…One study assessed AMD in patients with and without visual impairment [15]. One study explored the relationship of air pollution exposure with exudative and non-exudative AMD [18].…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

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Association between ambient air pollution and age-related macular degeneration: a meta-analysis

Wu,

Zhang,

2024

BMC Ophthalmol

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“…An interesting study evaluated the association of environmental factors on exudative and nonexudative age-related macular degeneration (AMD) [ 18 ]. Provider zip codes were used to collect environmental data including elevation, latitude, global horizontal irradiance (GHI) and direct normal irradiance (DNI), temperature and precipitation variables, and pollution variables.…”

Section: Iris Registry In Use – Various Advantages Of Big Datamentioning

confidence: 99%

Ophthalmology at the Forefront of Big Data Integration in Medicine: Insights from the IRIS Registry Database

Knapp,

Leng,

Rahimy

2023

Yale J Biol Med

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Ophthalmology stands at the vanguard of incorporating big data into medicine, as exemplified by the integration of The Intelligent Research in Sight (IRIS) Registry. This synergy cultivates patient-centered care, demonstrates real world efficacy and safety data for new therapies, and facilitates comprehensive population health insights. By evaluating the creation and utilization of the world’s largest specialty clinical data registry, we underscore the transformative capacity of data-driven medical paradigms, current shortcomings, and future directions. We aim to provide a scaffold for other specialties to adopt big data integration into medicine.

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Association of exposure to ultraviolet radiation and warm-season ozone air pollution with incident age-related macular degeneration: A nationwide cohort study in China

Qu,

Jiang,

Zhang

et al. 2024

Science of The Total Environment

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Association of Environmental Factors with Age-Related Macular Degeneration using the Intelligent Research in Sight Registry

Cited by 6 publications

References 23 publications

Association between ambient air pollution and age-related macular degeneration: a meta-analysis

Association between ambient air pollution and age-related macular degeneration: a meta-analysis

Ophthalmology at the Forefront of Big Data Integration in Medicine: Insights from the IRIS Registry Database

Association of exposure to ultraviolet radiation and warm-season ozone air pollution with incident age-related macular degeneration: A nationwide cohort study in China

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