Association of epicardial adipose tissue with coronary atherosclerosis is region-specific and independent of conventional risk factors and intra-abdominal adiposity

Wang, Tzung‐Dau; Lee, Wei-Jei; Shih, Fuh‐Yuan; Huang, Chien‐Hua; Chen, Wen‐Jone; Lee, Yuan‐Teh; Shih, Tiffany Ting-Fang; Chen, Ming-Fong

doi:10.1016/j.atherosclerosis.2010.07.055

Cited by 84 publications

(77 citation statements)

References 27 publications

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“…Chung et al [22] found that EAT volume measured by MDCT at the level of the left main coronary artery was the most reliable location, which was related to metabolic syndrome. Eventhough Wang et al [23] measured the thickest EAT at the right AV groove, they found that left AV groove EAT measurements were significantly related with CAD and metabolic syndrome [24]. In our study we also found that left AV groove EAT volumes were significant independent predictors of coronary atherosclerosis.…”

Section: Discussionsupporting

confidence: 74%

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The relationship between location-specific epicardial adipose tissue volume and coronary atherosclerotic plaque burden in type 2 diabetic patients

et al. 2017

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A b s t r a c tBackground and aim: Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot that plays an important role in the pathogenesis of coronary atherosclerosis. Due to its asymmetrical distribution, the relation between location-specific EAT measurements and coronary atherosclerosis remains unclear. Our study investigated the relationship between location-specific EAT volume and coronary atherosclerotic plaque burden that was detected by coronary computed tomography angiography (CCTA) in type 2 diabetic patients without coronary artery disease (CAD) history. Methods:A total of 157 consecutive diabetic patients who had undergone CCTA were included retrospectively. After evaluation of the CCTA images, the study population was divided into two groups according to the presence of coronary atherosclerosis. In both groups, total and left atrioventricular groove EAT volumes were measured. Results:Total and left atrioventricular groove EAT volumes were significantly associated with coronary atherosclerosis, but only left atrioventricular groove EAT volumes were an independent predictor for CAD. Also, total and left atrioventricular groove EAT volumes were positively correlated with C-reactive protein values (p = 0.0001/p = 0.0001) and the number of coronary atherosclerotic segments (p = 0.0001/p = 0.0001).

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Section: Discussionsupporting

confidence: 74%

“…In our study we also found that left AV groove EAT volumes were significant independent predictors of coronary atherosclerosis. There are several possible explanations to define the correlation between the left AV groove EAT volume and coronary atherosclerosis [23].…”

Section: Discussionmentioning

confidence: 99%

The relationship between location-specific epicardial adipose tissue volume and coronary atherosclerotic plaque burden in type 2 diabetic patients

et al. 2017

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“…Despite the simplicity of evaluating EAT with echocardiography (36), EAT should be measured in three dimensions by MDCT: regional thickness, cross-sectional area, and total volume (33,37). Therefore, MDCT can be used to assess CAC and EAT in ESRD patients at a high risk of CVD.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Epicardial Adipose Tissue and Malnutrition, Inflammation, Atherosclerosis/Calcification Syndrome in ESRD Patients

Türkmen

Kayıkçıoğlu²,

Özbek³

et al. 2011

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Malnutrition, inflammation, atherosclerosis/calcification (MIAC) and endothelial dysfunction are the most commonly encountered risk factors in the pathogenesis of cardiovascular disease in ESRD patients. Epicardial adipose tissue (EAT) is the true visceral fat depot of the heart. The relationship between CAD and EAT was shown in patients with high risk of coronary artery disease. In this study, we aimed to investigate the relationship between EAT and MIAC syndrome in ESRD patients.Design, setting, participants, & measurements Eighty ESRD patients and 27 healthy subjects enrolled in this cross-sectional study. EAT and coronary artery calcification score were measured by a multidetector computed tomography (MDCT) scanner. Patients with serum albumin Ͻ3.5 mg/dl were defined as patients with malnutrition; those with serum C-reactive protein level Ͼ10 ng/dl (normal range, 0 -5 ng/dl) had inflammation; and those with CACS Ͼ10 had atheroscleosis/calcification.Results Total CACS and EAT measurements were significantly higher in ESRD patients when compared with healthy subjects. There was a statistically significant relationship between EAT and CACS in ESRD patients (r ϭ 0.48). EAT measurements were higher in PD patients than HD patients. Twenty-four of the patients had no component, 31 had one component, 17 had two components, and nine had all of the MIAC components. EAT was found to be significantly increased when the presence of MIAC components increased. EAT was positively correlated with age, body mass index, and presence of MIAC. These parameters were also found as independent predictors of increased EAT.Conclusions We found a relationship between EAT and components of MIAC syndrome in ESRD patients.

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“…1 The total EATV was calculated on a highlighted fat map, with a threshold of −190 to −30 HU. 20 The EATV index was defined as EATV/body surface area. 1 Local EAT thicknesses were measured on short-axis view (Figure 1).…”

Section: Discussionmentioning

confidence: 99%

Local Thickness of Epicardial Adipose Tissue Surrounding the Left Anterior Descending Artery Is a Simple Predictor of Coronary Artery Disease　― New Prediction Model in Combination With Framingham Risk Score ―

Maimaituxun

Shimabukuro

Fukuda

et al. 2018

Circ J

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Association of epicardial adipose tissue with coronary atherosclerosis is region-specific and independent of conventional risk factors and intra-abdominal adiposity

Cited by 84 publications

References 27 publications

The relationship between location-specific epicardial adipose tissue volume and coronary atherosclerotic plaque burden in type 2 diabetic patients

The relationship between location-specific epicardial adipose tissue volume and coronary atherosclerotic plaque burden in type 2 diabetic patients

The Relationship between Epicardial Adipose Tissue and Malnutrition, Inflammation, Atherosclerosis/Calcification Syndrome in ESRD Patients

Local Thickness of Epicardial Adipose Tissue Surrounding the Left Anterior Descending Artery Is a Simple Predictor of Coronary Artery Disease　― New Prediction Model in Combination With Framingham Risk Score ―

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Association of epicardial adipose tissue with coronary atherosclerosis is region-specific and independent of conventional risk factors and intra-abdominal adiposity

Cited by 84 publications

References 27 publications

The relationship between location-specific epicardial adipose tissue volume and coronary atherosclerotic plaque burden in type 2 diabetic patients

The relationship between location-specific epicardial adipose tissue volume and coronary atherosclerotic plaque burden in type 2 diabetic patients

The Relationship between Epicardial Adipose Tissue and Malnutrition, Inflammation, Atherosclerosis/Calcification Syndrome in ESRD Patients

Local Thickness of Epicardial Adipose Tissue Surrounding the Left Anterior Descending Artery Is a Simple Predictor of Coronary Artery Disease ― New Prediction Model in Combination With Framingham Risk Score ―

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Local Thickness of Epicardial Adipose Tissue Surrounding the Left Anterior Descending Artery Is a Simple Predictor of Coronary Artery Disease　― New Prediction Model in Combination With Framingham Risk Score ―