Association of Estrogen Levels With Neuropsychological Performance in Women With Schizophrenia

Hoff, Anne L.; Kremen, William S.; Wieneke, Mary; Blankfeld, Howard M.; Faustman, William O.; Csernansky, John G.; Nordahl, Thomas E.

doi:10.1176/appi.ajp.158.7.1134

Cited by 92 publications

(49 citation statements)

References 44 publications

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“…Several studies already emphasised the importance of non-genomic actions of estrogen in the body. It is believed to play a role in neuroprotection of the brain [Garcia-Segura et al, 2001], the release of insulin from the pancreatic Langerhans islets [Ropero et al, 2002], and may also be involved in psychiatric diseases like Alzheimer's disease and schizophrenia [Hoff et al, 2001]. These findings are in support of a hypothesis that non-genomic actions of oestrogen are involved in the pathophysiology of Wolfram syndrome.…”

Section: Discussionmentioning

confidence: 61%

Sex-Related Hearing Impairment in Wolfram Syndrome Patients Identified by Inactivating <i>WFS1</i> Mutations

et al. 2003

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This study examined the audiovestibular profile of 11 Wolfram syndrome patients (4 males, 7 females) from 7 families, with identified WFS1 mutations, and the audiometric profile of 17 related heterozygous carriers of WFS1 mutations. Patients with Wolfram syndrome showed a downsloping audiogram and progressive hearing impairment. None of the carriers had sensorineural hearing loss. Two patients with missense (non-inactivating) mutations in WFS1 had normal hearing and mild symptoms of Wolfram syndrome and were excluded from the analyses. Of the identified patients with inactivating WFS1 mutations, 5 female patients were significantly more hearing impaired than four male patients (p < 0.05). Female patients showed hearing impairment progressing by 1.5–2.0 dB HL per year for the low frequencies and 4.0–4.5 dB HL per year for the mid and high frequencies. The age of onset (90% phoneme recognition score) was 21 years and the onset level 78 dB HL. The deterioration rate was 4.0% per year and the deterioration gradient 1.4% per dB HL. One of the 6 examined patients had vestibular areflexia.

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Section: Discussionmentioning

confidence: 61%

Sex-Related Hearing Impairment in Wolfram Syndrome Patients Identified by Inactivating <i>WFS1</i> Mutations

et al. 2003

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“…Several studies have recently confirmed earlier findings of disturbed gonadal function and hypo-estrogenism in women with schizophrenia [1,27,35,39,44,[56][57][58][59][60][61]. They described menstrual irregularities and reduced blood levels of estradiol, progesterone and gonadotropins (follicle-stimulating hormone, luteinizing hormone) throughout the menstrual cycle, plus anovulation in the majority of women with schizophrenia and related psychoses.…”

Section: Hypo-estrogenism In Women With Schizophrenia (The Hypothesismentioning

confidence: 54%

Estrogens and Gonadal Function in Schizophrenia and Related Psychoses

Riecher-Rössler¹,

Kulkarni

2010

Biological Basis of Sex Differences in Psychopharmacology

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“…[31][32][33] Speed & Flexibility has been labeled a femalespecific task, meaning women tend to outperform men in this area. Women perform better on female-oriented tasks when estrogen levels are high, for example, during the midluteal stage of the menstrual cycle.…”

Section: Discussionmentioning

confidence: 99%

Longer Duration of Hormonal Contraceptive Use Predicts Better Cognitive Outcomes Later in Life

Egan¹,

Gleason

2012

Journal of Women's Health

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Background: The cognitive effects of postmenopausal hormone therapy (HT) have been studied extensively, but little is known about the relationship between premenopausal hormone use and cognition. Hormonal contraceptive use vs. nonuse may be a potential factor influencing cognitive processes in midlife. The aim of this study is to explore the effect of modification of hormone milieu through use of hormonal contraception in premenopausal women and midlife cognitive function. Methods: Subjects were 261 cognitively normal women, aged 40-65 (mean l = 52), enrolled in the Wisconsin Registry for Alzheimer's Prevention. All women completed the Women's Health History Questionnaire and a self-report health history questionnaire and were administered a battery of neuropsychologic tests. Cognitive results were analyzed using summary scores for the domains of Verbal Ability, Visuo-spatial Ability, Working Memory, Verbal Learning & Memory, and Speed & Flexibility derived using a confirmatory factor analysis. Results: Hormonal contraceptive ever users performed significantly better than never users in the domains of Visuo-spatial Ability (l = 0.75, 95% confidence interval [CI] 0.23-1.28, p = 0.005) and Speed & Flexibility (l = 0.52, 95% CI -0.16-1.04, p = 0.007), with duration-dependent increases in performance, especially in ever users with ‡ 15 years of use. Conclusions: These data provide preliminary evidence that hormonal contraceptive use may influence cognitive outcomes, even years after use is discontinued. Hormonal contraceptive users scored better in domains of Visuospatial Ability and Speed & Flexibility than never users, with a duration-dependent trend. Further research is needed to explore the use of hormonal contraceptives to prevent or delay cognitive decline and to clarify the physiologic basis of this phenomenon.

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Association of Estrogen Levels With Neuropsychological Performance in Women With Schizophrenia

Abstract: Higher estrogen levels in female patients with schizophrenia are associated with better cognitive ability. These results may have implications for potential treatment of cognitive dysfunction with adjunctive estrogen in female patients with schizophrenia.

Cited by 92 publications

References 44 publications

Sex-Related Hearing Impairment in Wolfram Syndrome Patients Identified by Inactivating <i>WFS1</i> Mutations

Sex-Related Hearing Impairment in Wolfram Syndrome Patients Identified by Inactivating <i>WFS1</i> Mutations

Estrogens and Gonadal Function in Schizophrenia and Related Psychoses

Longer Duration of Hormonal Contraceptive Use Predicts Better Cognitive Outcomes Later in Life

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