Association of exceptional parental longevity and physical function in aging

Ayers, Emmeline; Barzilai, Nir; Crandall, Jill P.; Milman, Sofiya

doi:10.1007/s11357-014-9677-5

Cited by 22 publications

(35 citation statements)

References 37 publications

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“…We have previously reported that OPEL have a healthier phenotype than OPUS, with lower prevalence of chronic illnesses such as hypertension, diabetes mellitus, heart attacks, and strokes (8). Recently, we also showed that OPEL performed better than OPUS on objective and subjective measures of physical function in a cross-sectional analysis in the same cohort (12). Based on these findings, we hypothesized that OPEL may possess genetic "protection" that allows them to have a slower rate of decline in physical function compared to OPUS.…”

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confidence: 67%

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Association of Family History of Exceptional Longevity With Decline in Physical Function in Aging

Ayers¹,

Barzilai

Crandall³

et al. 2017

The Journals of Gerontology: Series A

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Background: Although many genetic and nongenetic factors interact to determine an individual's physical phenotype, there has been limited examination of the contribution of family history of exceptional parental longevity on decline in physical function in aging. Methods: The LonGenity study recruited a relatively genetically homogenous cohort of Ashkenazi Jewish adults age 65 and older, who were defined as either offspring of parents with exceptional longevity ([OPEL]: having at least one parent who lived to age 95 or older) or offspring of parents with usual survival ([OPUS]: neither parent survived to age 95). Decline in performance on objective measures of strength (grip strength), balance (unipedal stance), and mobility (gait speed) as well as a composite physical function measure, the Short physical performance battery (SPPB), were compared between the two groups over a median follow-up of 3.2 years, accounting for age, sex, education, and comorbidities. Results: Of the 984 LonGenity participants (mean age 76, 55% women), 448 were OPEL and 536 were OPUS. Compared to OPUS, OPEL had slower decline on measures of unipedal stance (−0.03 log-units/year, p = .026), repeated chair rise (0.13 s/year, p = .020) and SPPB (−0.11 points/year, p = .002). OPEL women had slower decline on chair rise and SPPB scores compared to OPUS women, although OPEL men had slower decline on unipedal stance compared to OPUS men. Conclusion: Our findings provide evidence that variation in late-life decline in physical function is associated with familial longevity, and may vary for men and women.

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confidence: 67%

“…Covariates were selected based on results from our cross-sectional analysis (12). Presence of depression, diabetes, heart failure, hypertension, myocardial infarction, angina, strokes, Parkinson's disease, chronic obstructive lung disease, and arthritis was used to calculate a global health summary (GHS) as previously described (15).…”

Section: Covariatesmentioning

confidence: 99%

Association of Family History of Exceptional Longevity With Decline in Physical Function in Aging

Ayers¹,

Barzilai

Crandall³

et al. 2017

The Journals of Gerontology: Series A

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“…Individual study details have been published previously [14–18], and are briefly summarized here. LonGenity recruited an Ashkenazi Jewish cohort from New York City (USA) and surrounding counties with the aim of identifying longevity associated genotypes [14].…”

Section: Methodsmentioning

confidence: 99%

Motoric Cognitive Risk Syndrome and Falls Risk: A Multi-Center Study

Callisaya

Ayers

Barzilai

et al. 2016

JAD

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Background The Motoric Cognitive Risk Syndrome (MCR) is characterized by slow gait speed and cognitive complaints. Objectives The objective of this study was to determine if the presence of MCR increases the risk of falls in older people. Methods Individual participant data (n = 6,204) from five longitudinal studies from three countries were used for this analysis. MCR diagnosis was defined as both the presence of objectively measured slow gait speed and subjective cognitive complaints in those without dementia or mobility disability. Falls were prospectively ascertained using phone calls or questionnaires. Log binomial regression was performed to determine if MCR increased the risk of falls separately in each cohort. Random effects meta-analysis was used to pool results from all cohorts. Results The mean age of participants was 74.9 (SD 6.8) years and 44% (n = 2728) were male. Overall 33.9% (n = 2104) reported a fall over follow-up. Pooled relative risk of MCR with any falls was RR 1.44 95% CI 1.16, 1.79. The components of MCR, slow gait (RR 1.30 95% CI 1.14, 1.47) and cognitive complaint (RR 1.25, 95% CI 1.07, 1.46) were also associated with an increased risk of any falls. In sub-analyses MCR was associated with any fall independent of previous falls (RR 1.29 95% CI 1.09, 1.53) and with multiple falls (RR 1.77, 95% CI 1.25, 2.51). Conclusion MCR is associated with an increased risk of falls. The increase in risk was higher than for its individual components. The simplicity of the MCR makes it an attractive falls risk screening tool for the clinic.

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“…Both OPEL and OPUS were recruited through systematic searches of publicly available voter registration lists, contacts at synagogues and community organizations, and advertisements in Jewish newspapers. 16 A subset of eligible subjects (n=85) were recruited from the Einstein Aging Study and were cross-enrolled. Potential participants were contacted by mail and then by telephone to assess interest and eligibility.…”

Section: Methodsmentioning

confidence: 99%

Effect of Exceptional Parental Longevity and Lifestyle Factors on Prevalence of Cardiovascular Disease in Offspring

Gubbi

Schwartz

Crandall

et al. 2017

The American Journal of Cardiology

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Offspring of parents with exceptional longevity manifest lower prevalence of cardiovascular disease (CVD) but the role of lifestyle factors in this unique cohort is not known. Our study tested whether individuals with exceptional parental longevity have lesser prevalence of CVD independent of lifestyle factors. Prevalence of CVD and CVD risk factors was assessed in a population of community dwelling Ashkenazi Jewish adults aged 65-94 years. Participants included offspring of parents with exceptional longevity (OPEL, n=395), defined as having at least one parent living past the age of 95 years, and offspring of parents with usual survival (OPUS, n=450), defined as having neither parent survive to 95 years. Medical and lifestyle information was obtained using standardized questionnaires. Socioeconomic status was defined based on validated classification scores. Dietary intake was evaluated with the Block Brief Food Frequency Questionnaire (FFQ 2000) in a sub-group of the study population (n=234). Our study found no significant differences in the prevalence of obesity, smoking, alcohol use, physical activity, social strata scores and dietary intake between the two groups. After adjustment for age and sex, the OPEL demonstrated 29% lower odds of having hypertension (95% CI 0.53-0.95), 65% lower odds of having had a stroke (95% CI 0.14-0.88), and 35% lower odds of having CVD (95% CI 0.43-0.98), compared with OPUS. In conclusion, exceptional parental longevity is associated with lower prevalence of CVD independent of lifestyle, socioeconomic status and nutrition; thus, highlighting the potential role of genetics in disease-free survival among individuals with exceptional parental longevity.

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Association of exceptional parental longevity and physical function in aging

Cited by 22 publications

References 37 publications

Association of Family History of Exceptional Longevity With Decline in Physical Function in Aging

Association of Family History of Exceptional Longevity With Decline in Physical Function in Aging

Motoric Cognitive Risk Syndrome and Falls Risk: A Multi-Center Study

Effect of Exceptional Parental Longevity and Lifestyle Factors on Prevalence of Cardiovascular Disease in Offspring

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