Association of Family History of Exceptional Longevity With Decline in Physical Function in Aging

Ayers, Emmeline; Barzilai, Nir; Crandall, Jill P.; Milman, Sofiya

doi:10.1093/gerona/glx053

Cited by 14 publications

(17 citation statements)

References 42 publications

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“…These findings support the notion that individuals with familial longevity may be more likely to not only achieve longevity themselves but to also enjoy their later years without morbidity or disability. Our findings agree with prior studies showing that offspring of long-lived parents may live longer and healthier lives [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. A study among Italians observed that, compared with an age-matched group without long-lived parents and from a similar birth cohort, offspring of centenarians had lower BMI and smaller proportion of obese individuals, and were also more likely to be able to walk 500 meters without requiring help [20].…”

Section: Discussionsupporting

confidence: 92%

“…In the New England Centenarian Study, offspring of centenarians had 78%, 83% and 86% lower risk of developing myocardial infarction, stroke and diabetes, respectively, than a similarly aged referent cohort [5]. Among Ashkenazi Jewish adults, individuals with either one or two compared with no parents who survived to age 95 had reduced decline in objectively-measured physical function during a median 3-year follow-up period [17].…”

Section: Introductionmentioning

confidence: 97%

“…cardiovascular disease [CVD] and diabetes), have fewer CVD risk factors (e.g. hypertension) and have slower declines in physical and cognitive function [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. In the New England Centenarian Study, offspring of centenarians had 78%, 83% and 86% lower risk of developing myocardial infarction, stroke and diabetes, respectively, than a similarly aged referent cohort [5].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Parental longevity predicts healthy ageing among women

Shadyab

Manson

et al. 2018

Age and Ageing

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Parental longevity predicts healthy ageing among women

Shadyab

Manson

et al. 2018

Age and Ageing

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“…These studies also indicate that the difference in 'relative risk' of living to 90 or 95 years is very marginal, which suggests limited heritability of longevity at these ages. Moreover, multiple extreme long-lived individuals are classified as ³ 95 years of age, regardless of gender (Ayers et al, 2017;Deluty et al, 2015;Gubbi et al, 2017;Perice et al, 2016). As females generally live to older ages, we calculated and applied a sex-specific age threshold for long-lived status.…”

Section: Exome-and Genome-wide Association Analysis Of Long-lived Casmentioning

confidence: 99%

Exome-wide association studies in general and long-lived populations identify genetic variants related to human age

Sin‐Chan

Gosalia

Gao

et al. 2020

Preprint

Self Cite

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Aging is characterized by degeneration in cellular and organismal functions leading to increased disease susceptibility and death. Although our understanding of aging biology in model systems has increased dramatically, large-scale sequencing studies to understand human aging are now just beginning. We applied exome sequencing and association analyses (ExWAS) to identify age-related variants on 58,470 participants of the DiscovEHR cohort. Linear Mixed Model regression analyses of age at last encounter revealed variants in genes known to be linked with clonal hematopoiesis of indeterminate potential, which are associated with myelodysplastic syndromes, as top signals in our analysis, suggestive of age-related somatic mutation accumulation in hematopoietic cells despite patients lacking clinical diagnoses. In addition to APOE, we identified rare DISP2 rs183775254 (p = 7.40x10-10) and ZYG11A rs74227999 (p = 2.50x10-08) variants that were negatively associated with age in either both sexes combined and females, respectively, which were replicated with directional consistency in two independent cohorts. Epigenetic mapping showed these variants are located within cell-type-specific enhancers, suggestive of important transcriptional regulatory functions. To discover variants associated with extreme age, we performed exome-sequencing on persons of Ashkenazi Jewish descent ascertained for extensive lifespans. Case-Control analyses in 525 Ashkenazi Jews cases (Males greater than 92 years, Females greater than 95years) were compared to 482 controls. Our results showed variants in APOE (rs429358, rs6857), and TMTC2 (rs7976168) passed Bonferroni-adjusted p-value, as well as several nominally-associated population-specific variants. Collectively, our Age-ExWAS, the largest performed to date, confirmed and identified previously unreported candidate variants associated with human age.

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“…The exception has been the lack of preventive success in reducing drowning rates among seniors (Mahony, Peden, Franklin, Pearn, & Scarr, 2017;Peden, Franklin, & Queiroga, 2017). This preventive challenge will intensify (Ayers, Barzilai, Crandall, Milman, & Verghese, 2017) as worldwide the elderly population (i.e., 60 years and older) is predicted to double between 2017 and2050 (World Health Organization, 2015).…”

Section: Introductionmentioning

confidence: 99%

Unintentional Bathtub Drowning Deaths Among Those Aged 65 Years and Older in Australia

Peden¹,

Franklin²,

Pearn³

et al. 2019

IJARE

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When compared with other age groups, fatal drowning rates among seniors have stayed static. This study identifies causal factors in unintentional bathtub drowning deaths among people aged 65 years and over. This study is a 10-year (2003-2012) total population retrospective survey of all unintentional bathtub (baths, spa baths and showers) drowning deaths afflicting people aged 65 years and over. Data were sourced from the Australian National Coronial Information System. Risk factors and circumstantial variables were analysed including sex, age, activity prior to drowning, alcohol, drugs, pre-existing medical conditions, living circumstances, time until found, and performance of cardio-pulmonary resuscitation (CPR). There were 32 fatalities (20 females, 12 males); 41% drowned after a fall into the bath. High blood alcohol (≥0.05%) was disproportionately represented. Twenty-six people (81%) had a pre-existing medical condition, deemed contributory in 19 cases including cardiac (n=9) and sarcopenia or frailty (n=5). Of those with medical conditions, 69% had blood levels of prescribed drugs, commonly analgesics (n=10). Seven cases recorded both drugs and alcohol. In half of all fatalities (50%), the person resided alone. In ten cases (31%) the person was not found for one or more days. Bathtub drowning afflicting the elderly poses an unmet challenge. This study has identified five areas for targeted prevention: Pre-existing medical conditions, alcohol, falls in the bath, review of medications; and if practical, advising family members of bathing. Increased awareness of drowning among this age group (and carers) is required as the aged population increases.

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Association of Family History of Exceptional Longevity With Decline in Physical Function in Aging

Cited by 14 publications

References 42 publications

Parental longevity predicts healthy ageing among women

Parental longevity predicts healthy ageing among women

Exome-wide association studies in general and long-lived populations identify genetic variants related to human age

Unintentional Bathtub Drowning Deaths Among Those Aged 65 Years and Older in Australia

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