Association of fibrinogen, fibrin degradation product, and D-dimer level with disease severity in hospitalized COVID-19 patients "&amp;#".ord($0).";""&amp;#".ord($0).";""&amp;#".ord($0).";" A cross-sectional study in Eastern India

Samaddar, Aparajita; Talukdar, Manas; Pal, Santasmita; Saha, Ipsita; Chowdhury, Anadi

doi:10.5455/njppp.2022.12.03124202221032022

Cited by 2 publications

(7 citation statements)

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“…Many diseases, including diabetes, blood pressure, surgeries and bacterial infection of various types of pathogens. The result of this study agrees with many previous studies as [19], [3], [14], [15], [22], [11], [16], [18], [21], [25], [26], [27] that the D-Daimer indicate to various disease, It is not limited to virus infection only.…”

Section: Discussionsupporting

confidence: 92%

“…Figure (3) It can be seen that the Frequency and Percent of the type of infection, which the highest percent for viral infection 498 (89.6%), followed by Surgery 23(4.1%), Deep Vein Thrombosis18 (3.2%), and Respiratory Diseases 17(3.1%). It is apparent from the results in a table (5) and Figure 4 that the D. Dimer result of Types of infection the highest result was for viral infection (498), followed by Surgery (23), Deep Vein Thrombosis (18), and Respiratory Diseases (17). Figure (5) The Figure illustrates the relationship between D. Dimer Result and Chronic Disease that the blood pressure was the highest followed by pneumonia, diabetes Miletus, Anemia, kidney disease, and Heart disease.…”

Section: Discussionmentioning

confidence: 94%

“…Elevated level of D-dimer, fibrinogen, and FDP is indicator of disease progression in COVID-19. Thus, regular estimation of these simple coagulation parameters may predict disease severity and help in adequate management [18]. Elevated D-dimer levels reportedly predict the onset of deep vein thrombosis (DVT) after total hip arthroplasty or total knee arthroplasty [9].…”

Section: Introductionmentioning

confidence: 99%

“…There was no publication bias. CRP and D-dimer rose with age in COVID-19 diabetic and non-diabetic patients [18]. Over thirty different D-dimer assays, using more than twenty different types of monoclonal antibodies, are currently commercially available available [13].…”

Section: Introductionmentioning

confidence: 99%

“…Over thirty different D-dimer assays, using more than twenty different types of monoclonal antibodies, are currently commercially available available [13]. Regular estimation of these simple coagulation parameters may predict disease severity and help in adequate management [18]. Cancer, and pneumonia were frequently present when ultra-high plasma D-dimer levels were encountered, and mortality was high when the levels were >15,000 ng/mL cancer, and pneumonia were frequently present when ultra-high plasma D-dimer levels were encountered, and mortality was high when the levels were >15,000 ng/mL, [24].…”

Section: Introductionmentioning

confidence: 99%

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The relationship of D-Dimer level with various diseases

Eljamay¹,

Younis

Elgebaily

2022

dsi

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D-dimer is a biomarker of thrombosis considered to predict poor outcomes in patients with various diseases. This study aimed to find out the relationship between levels of D dimer in different diseases. 556 blood sample analyses for D dimer Patients' were collected from private laboratories, isolation, and health care centres in the Derna, Al- Gubba City, and its surrounding areas, Plasma separation from the tube containing sodium citrate, Preparation of I-Chroma D-Dimer Quantitative kits reagent. The Frequency and Percent of the Gender were 278 (50%) for males, 278 (50%) for females and for Chronic Diseases, the highest percent for Pneumonia was 121 (21.8%), followed by Blood Pressure at 77 (13.8 %). Diabetes Miletus 51 (9.2%), and for other diseases 71 (12.8%), the type of infection, the highest percent for Viral Infection was 498 (89.6%), followed by Surgery 23 (4.1%), Deep Vein Thrombosis 18 (3.2%), and for Respiratory Diseases 17 (3.1%), the level of D dimer which the highest percent for Moderate 247 (44.4%), followed by High 149 (26.8%). The result of D dimer was Normal 109 (19.6%), and the very high result of 51 (9.2%), the relationship between D dimer result and chronic disease was the highest for blood pressure followed by pneumonia, diabetes Miletus, Anemia, kidney disease, and Heart disease, The correlation between D dimer for age and chronic diseases, p-value < & = 0.05, and there is not a significant relationship between D dimer and type of infection and gender p-value < 0.05. We concluded that the obtained results prove that among obtained results, there is a strong relationship between age and chronic diseases, an increase in the level of D-dimer, level in the blood is not an indication of a specific disease, but rather a signal and alert for several diseases, many diseases

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The relationship of D-Dimer level with various diseases

Eljamay¹,

Younis

Elgebaily

2022

dsi

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Hemostatic and liver function parameters as COVID-19 severity markers

Iqbal,

Mudatsir,

Harapan

et al. 2024

Narra J

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Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a disease newly discovered in December 2019 which affects coagulation cascade and liver functions. The aim of this study was to investigate the potential of hemostatic and liver function parameters as severity markers in COVID-19 patients. This study was an observational analytic with cohort retrospective design using total sampling method. Data were retrieved from medical record of COVID-19 patients admitted to provincial hospital in Banda Aceh, Indonesia from March 2020 to March 2022. There were 1208 data eligible for the study after applying certain criteria. Mann–Whitney, logistic regression, and receiving operating characteristic (ROC) analyses were used to analysis the data. Thrombocyte count (p<0.001), prothrombin time (p<0.001), activated partial thromboplastin time (p<0.001), D-dimer (p<0.001), fibrinogen (p<0.001), aspartate aminotransferase (p<0.001), and alanine transaminase (p<0.001) significantly increased in severe compared to mild COVID-19 patients. After being adjusted, age (odds ratio (OR); 1.026 (95% confidence interval (CI): 1.016–1.037) was the most significant factor in predicting COVID-19 severity. Fibrinogen (cut-off 526.5 mg/L) was the best parameter associated with COVID-19 severity with 70% sensitivity and 66.4% specificity. Meanwhile, D-dimer (cut-off 805 ng/mL) had a sensitivity of 72.3% and specificity of 66.4%. Combining the parameters resulted in improved sensitivity to 82.0% with a slight decline of specificity to 65.5%. In conclusion, fibrinogen and D-dimer level on admission could be used as biomarkers in predicting COVID-19 prognosis. Routine monitoring and evaluation of laboratory testing especially D-dimer and fibrinogen could be implemented in order to reduce morbidity and mortality rate of COVID-19.

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Association of fibrinogen, fibrin degradation product, and D-dimer level with disease severity in hospitalized COVID-19 patients "&#".ord($0).";""&#".ord($0).";""&#".ord($0).";" A cross-sectional study in Eastern India

Cited by 2 publications

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The relationship of D-Dimer level with various diseases

The relationship of D-Dimer level with various diseases

Hemostatic and liver function parameters as COVID-19 severity markers

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