Association of Fibrinogen with Glycemic Control and Albumin Excretion Rate in Patients with Non-Insulin-Dependent Diabetes Mellitus

Bruno, Graziella; Cavallo‐Perin, P.; Bargero, G; Borra, M; D'Errico, Nicola; Pagano, Gianfranco

doi:10.7326/0003-4819-125-8-199610150-00005

Cited by 69 publications

(70 citation statements)

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“…The present study adds to this information, showing that a further increase not only of fibrinogen concentration but also of its synthesis occurs when type 2 diabetes patients are also albuminuric (Table 1) [7,8]. The slightly higher rate of fibrinogen absolute synthesis rate in the macro-vs the microalbuminuric patients may indicate some sort of consumptive coagulopathy or an increased rate of disappearance of fibrinogen in the former.…”

Section: Discussionsupporting

confidence: 51%

“…It increases cardiovascular risk in type 2 diabetes mellitus [30,31], probably because it reflects widespread increased vascular permeability causing organ damage [28,31,32]. Albuminuria and hyperfibrinogenaemia, another cardiovascular risk factor, are frequently associated [7,8] in diabetes. Such an association is important in that fibrinogen, an acutephase protein, is a powerful and independent cardiovascular risk factor [1][2][3].…”

Section: Discussionmentioning

confidence: 99%

“…Hyperfibrinogenaemia is common in type 2 diabetes, and is often associated with albuminuria [4][5][6][7][8][9]. The mechanism(s) of such an association in diabetes are not known.…”

Section: Introductionmentioning

confidence: 99%

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Diabetic nephropathy is associated with increased albumin and fibrinogen production in patients with type 2 diabetes

et al. 2006

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Aims/hypothesis: Hyperfibrinogenaemia and albuminuria are cardiovascular risk factors, often coexisting in diabetic and non-diabetic people. Albuminuria in turn is associated with a compensatory albumin overproduction in non-diabetic patients. It is not known whether the presence of albuminuria in patients with type 2 diabetes mellitus is associated with greater albumin and fibrinogen production rates than in normoalbuminuric patients. Subjects, materials, and methods: Using leucine isotope methods, we measured fractional and absolute synthesis rates (FSR, ASR) of albumin and fibrinogen in post-absorptive type 2 diabetic patients with either normal (n=11) or increased (n=10) urinary albumin excretion. Results: In albuminuric patients, albumin FSR (16.2± 1.5%/day) and ASR (20.5±1.9 g/day) were greater (p<0.02 and p<0.05, respectively) than in normoalbuminuric patients (FSR=11.5±1.1%/day; ASR=15.7±1.2 g/day). Fibrinogen FSR was similar between patients with normal and increased albumin excretion, but concentration, the circulating pool and ASR of fibrinogen were 40 to 50% greater (p<0.035) in patients with albuminuria. Albuminuria was positively correlated with albumin ASR, with fibrinogen concentration, the fibrinogen pool and ASR, whereas albumin synthesis was inversely correlated with calculated oncotic pressure. Conclusions/interpretation: Synthesis of albumin and fibrinogen is upregulated in type 2 diabetic patients with increased urinary albumin excretion. Albuminuria is associated with enhanced fibrinogen and albumin synthesis.

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

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Diabetic nephropathy is associated with increased albumin and fibrinogen production in patients with type 2 diabetes

et al. 2006

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“…It modifies foam cell formation and several inflammatory products, contributing to the onset of atherosclerosis [31]. Fibrinogen, which is correlated with glycosylated haemoglobin and microalbuminuria [32], is known as an acute phase reactant. Increased levels of sVCAM-1, which mediates the adhesion and transmigration of leucocytes to the vascular endothelial wall, are associated with an increased risk of cardiovascular mortality in Type 2 diabetes [33].…”

Section: Discussionmentioning

confidence: 99%

Moderate alcohol intake and markers of inflammation and endothelial dysfunction among diabetic men

et al. 2004

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Aims/hypothesis. Type 2 diabetes mellitus is characterised by heightened inflammation and endothelial dysfunction. Moderate alcohol intake has been associated with a reduced risk of cardiovascular disease in Type 2 diabetic patients. It remains to be determined whether there is an association between alcohol and inflammation in individuals with diabetes. Methods. We investigated the relationship between alcohol intake and inflammation in 726 of 18,159 men who returned blood samples in the Health Professionals Follow-up Study and had confirmed Type 2 diabetes at blood draw. Results. In age-adjusted analyses, alcohol intake was associated with lower levels of HbA 1 c, fibrinogen, soluble tumour necrosis factor receptor-2 (sTNF-R2) and soluble vascular adhesion molecule-1 (sVCAM-1), and with higher levels of HDL cholesterol and adiponectin (p value for trends <0.05). After adjustment for age, HbA 1 c, insulin use, fasting status, smoking, BMI, physical activity, aspirin use, prevalence of cardiovascular disease and dietary factors, each additional drink per day was related to increased HDL cholesterol (0.053 mmol/l, p<0.0001) and adiponectin (0.8 µg/ml, p=0.01), and decreased sTNFR-2 (73 pg/ml, p=0.03), fibrinogen (0.302 µmol/l, p=0.02) and sVCAM-1 (33 ng/ml, p=0.02). The relationship between alcohol and inflammatory biomarkers persisted when subjects were stratified according to HbA 1 c levels. Conclusions/interpretation. Moderate alcohol intake may have a beneficial effect on markers of inflammation and endothelial dysfunction in Type 2 diabetic patients.Keywords Alcohol · Cardiovascular disease · Diabetes mellitus · Inflammation

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“…Studies have shown that formation of an occlusive thrombus, on a damaged atherosclerotic lesion is the most common precipitating factor of acute myocardial infarction. Evidence also suggests that fibrinogen has a role, both in the early stages of plaque formation and late complications of cardiovascular disease [2]. The excess cardiovascular morbidity and mortality among diabetics have not been fully explained by major risk factors such as hypertension, cigarette smoking and hypercholesterolemia.…”

Section: Introductionmentioning

confidence: 99%

A Study of Plasma Fibrinogen Level in Type-2 Diabetes Mellitus and its Relation to Glycemic Control

Bembde

2011

Indian J Hematol Blood Transfus

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The high prevalence of classic cardiac risk factors in patients with type 2 diabetes mellitus does not explain the increased cardiovascular related morbidity and mortality in these patients. Fibrinogen may have a role in this excess risk. This study is undertaken to know the fibrinogen levels in type 2 diabetes mellitus and its relations to glycemic control. In the present study fibrinogen levels (Clauss method) were estimated in 100 type 2 diabetic subjects and 100 age and sex matched controls. Fibrinogen was correlated with various parameters like glycosylated hemoglobin (cation exchange resin method), age, sex, smoking, body mass index (kg/m 2 ), hypertension and ischemic heart disease. Higher plasma fibrinogen levels were found in type 2 diabetes mellitus patients (656 ± 130 mg/dl) as compared to controls (324 ± 139 mg/dl) which were statistically significant. Fibrinogen levels were associated with age (P \ 0.01), hypertension (P \ 0.01), body mass index (P \ 0.01), smoking (P \ 0.01), ischemic heart disease (P \ 0.01), and glycosylated hemoglobin (r = 0.49) in diabetics in a significant manner. But no correlation was found with sex (P \ 0.05) in diabetes. In controls, association was found between fibrinogen levels and smoking (P \ 0.01) and body mass index (P \ 0.01). Patients with type 2 diabetes mellitus had a high prevalence of hyperfibrinogenemia. Fibrinogen levels were independently associated with hemoglobin A1c values, which suggests that fibrinogen may be involved in the increased cardiovascular risk of patients with type 2 diabetes mellitus.

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Association of Fibrinogen with Glycemic Control and Albumin Excretion Rate in Patients with Non-Insulin-Dependent Diabetes Mellitus

Cited by 69 publications

References 0 publications

Diabetic nephropathy is associated with increased albumin and fibrinogen production in patients with type 2 diabetes

Diabetic nephropathy is associated with increased albumin and fibrinogen production in patients with type 2 diabetes

Moderate alcohol intake and markers of inflammation and endothelial dysfunction among diabetic men

A Study of Plasma Fibrinogen Level in Type-2 Diabetes Mellitus and its Relation to Glycemic Control

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