Association of four apolipoprotein B polymorphisms with lipid profile and stenosis in Tunisian coronary patients

Raîs, L.; Omezzine, Asma; Kacem, Slim; Rejeb, Jaleleddine Ben; Boumaiza, Imen; Ibtihel, Ben Hadjmbarek; Kaouther, Kchock; Belkahla, Radhia; Nabila, Ben Rejeb; Nabli, Naoufel; Ahmed, Ben Abdelaziz; Boughzala, E.; Bouslama, Ali

doi:10.1007/s12041-012-0127-9

Cited by 16 publications

(11 citation statements)

References 17 publications

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“…However, Benhizia, et al in contrast to the results of our study exhibited that Ins allele is associated with higher risk of obesity [13]. Similar to our investigation, Lamia, et al showed that carriers of Del allele had higher LDL-c concentration than subjects with Ins genotype [14]. Similarly, Halsall, et al investigation on 725 non-diabetic British subjects indicated that TC and LDL-c levels were significantly higher in Del/Del homozygotes compare with carriers of Ins allele in men but not in women [15].…”

Section: Hdl-c (X ± Sd (Mg/dl) CV (%))supporting

confidence: 83%

“…Study of Benhizia et al on rat hepatoma cells was showed that Ins allele carriers compare with Del/Del genotype have higher serum TG and VLDL levels [13]. However, several previous studies have reported that Del allele of ApoB gene associated with dyslipidemia, especially hyper-LDL-cholesterolemia [14,15]. Additionally, Saha, et al has studied the association among the ApoB Ins/Del polymorphism and body mass index (BMI) in Hindi healthy population in Singapore and found that Del allele carriers have higher BMI compare with Ins/Ins homozygotes [16].…”

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confidence: 97%

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Association between Insertion/Deletion Polymorphism of ApoB Gene with Dyslipidemia and Obesity Risk in Patients with Type 2 Diabetes

Rafiee¹,

Sotoudeh²,

Djalali³

et al. 2016

Journal of Obesity and Overweight

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Background: Several studies have suggested that Insertion/Deletion polymorphism of ApoB gene is associated with obesity, dyslipidemia, diabetes and coronary heart disease (CHD). However, data are limited and inconsistence. The objective of this study is to investigate the aassociation between insertion/Deletion polymorphism of ApoB gene and dyslipidemia and obesity risk in patients with type 2 diabetes (T2D).

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Section: Hdl-c (X ± Sd (Mg/dl) CV (%))supporting

confidence: 83%

mentioning

confidence: 97%

Association between Insertion/Deletion Polymorphism of ApoB Gene with Dyslipidemia and Obesity Risk in Patients with Type 2 Diabetes

Rafiee¹,

Sotoudeh²,

Djalali³

et al. 2016

Journal of Obesity and Overweight

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“…very low density lipoprotein (VLDL), apoB-100) derived lipoproteins and plays an important role in the transport of triacylglycerol (TAG) and cholesterol [ 1 ]. The APOB insertion/deletion (ins/del) polymorphism (rs17240441), which produces a difference of three amino acids in the signal peptide, has been associated with fasting total cholesterol (TC) [ 2 , 3 ], TAG [ 4 , 5 ], high density lipoprotein-cholesterol (HDL-C) [ 2 ] and low density lipoprotein-cholesterol (LDL-C) [ 2 , 3 ] concentrations, along with cardiovascular disease-related outcomes [ 6 - 11 ]. In addition, the effect of this polymorphism on lipid metabolism appears to be modulated by dietary fat and cholesterol intakes [ 4 , 12 ].…”

Section: Resultsmentioning

confidence: 99%

The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults

Vimaleswaran

Minihane

et al. 2015

Nutr Metab (Lond)

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BackgroundApolipoprotein (apo)B is the structural apoprotein of intestinally- and liver- derived lipoproteins and plays an important role in the transport of triacylglycerol (TAG) and cholesterol. Previous studies have examined the association between the APOB insertion/deletion (ins/del) polymorphism (rs17240441) and postprandial lipaemia in response to a single meal; however the findings have been inconsistent with studies often underpowered to detect genotype-lipaemia associations, focused mainly on men, or with limited postprandial characterisation of participants. In the present study, using a novel sequential test meal protocol which more closely mimics habitual eating patterns, we investigated the impact of APOB ins/del polymorphism on postprandial TAG, non-esterified fatty acids, glucose and insulin levels in healthy adults.FindingsHealthy participants (n = 147) consumed a standard test breakfast (0 min; 49 g fat) and lunch (330 min; 29 g fat), with blood samples collected before (fasting) and on 11 subsequent occasions until 480 min after the test breakfast. The ins/ins homozygotes had higher fasting total cholesterol, LDL-cholesterol, TAG, insulin and HOMA-IR and lower HDL-cholesterol than del/del homozygotes (P < 0.017). A higher area under the time response curve (AUC) was evident for the postprandial TAG (P < 0.001) and insulin (P = 0.032) responses in the ins/ins homozygotes relative to the del/del homozygotes, where the genotype explained 35% and 7% of the variation in the TAG and insulin AUCs, respectively.ConclusionsIn summary, our findings indicate that the APOB ins/del polymorphism is likely to be an important genetic determinant of the large inter-individual variability in the postprandial TAG and insulin responses to dietary fat intake.

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“…APOB 3ʹ-VNTR alleles with relatively larger number of repeats have association with a number of disease conditions. Alleles with higher repeats (≥36 repeats) were shown to be strongly correlated with coronary heart disease 18,[33][34][35] . APOB 3ʹ-VNTR alleles with higher repeats are also significantly associated with higher levels of total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) 36,37 .…”

Section: Discussionmentioning

confidence: 99%

Association of APOB 3ʹ-VNTR alleles with type 2 diabetes, BMI, systolic and diastolic blood pressure

Sajib

Khan

Haque

et al. 2018

Bangladesh J Med Sci

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Background: Apolipoprotein B (APOB) is a component of chylomicrons, low-density lipoproteins (LDL), very low-density lipoproteins (VLDL), intermediate density lipoproteins (IDL) and functions as the main protein for transporting cholesterol to peripheral cells. APOB gene has an AT-rich VNTR site at its 3ʹ-untranslated region (3ʹ-UTR). APOB 3ʹ-VNTR alleles with ≥36 repeats have been shown to be strongly associated with increased serum lipid levels, gallstone formation and coronary artery disease. Objectives: To investigate any possible association of APOB 3ʹ-VNTR alleles with type 2 diabetes, BMI, systolic and diastolic blood pressure. Materials and methods: APOB 3ʹ-VNTR region in the DNA of non-diabetic controls and type 2 diabetic patients were amplified by polymerase chain reaction (PCR) and the numbers of core repeat in the amplified products were determined. Frequencies of the APOB alleles and genotypes among the controls and the patients were calculated and statistical analyses were performed. Results and discussion: Here we report for the first time that APOB 3ʹ-VNTR alleles have different distribution frequencies among type 2 diabetic and non-diabetic individuals. We also observed higher body mass index (BMI), systolic and diastolic blood pressures in individuals who had at least one APOB 3ʹ-VNTR allele with ≥35 repeats. Conclusion: Our study might bridge among the genetic signature of APOB 3ʹ-VNTR, high APOB protein level in blood, diabetes and other co-morbidities.

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Association of four apolipoprotein B polymorphisms with lipid profile and stenosis in Tunisian coronary patients

Cited by 16 publications

References 17 publications

Association between Insertion/Deletion Polymorphism of ApoB Gene with Dyslipidemia and Obesity Risk in Patients with Type 2 Diabetes

Association between Insertion/Deletion Polymorphism of ApoB Gene with Dyslipidemia and Obesity Risk in Patients with Type 2 Diabetes

The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults

Association of APOB 3ʹ-VNTR alleles with type 2 diabetes, BMI, systolic and diastolic blood pressure

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