Association of FSHR missense mutations with female infertility, in silico investigation of their molecular significance and exploration of possible treatments using virtual screening and molecular dynamics

Haqiqi, Haniye; Farsimadan, Marziye; Abiri, Ardavan; Sharafshah, Alireza; Vaziri, Hamidreza; Zahiri, Ziba

doi:10.1016/j.ab.2019.113433

Cited by 14 publications

(6 citation statements)

References 59 publications

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“…Female infertility in different resources defines as a woman of reproductive age not being able to get pregnant after a year of trying or keeps having miscarriages 3 . Not being able to ovulate has been considered the major cause of infertility among women that can be a result of different factors including, social, genetic, endocrine, physiological and phycological factors as well as lifestyle habits (ie smoking and alcohol consumption) 4 . However, approximately 15%–30% of cases of female infertility still remain unexplained 5,6 .…”

Section: Introductionmentioning

confidence: 99%

The effects of hepatitis B virus infection on natural and IVF pregnancy: A meta‐analysis study

Farsimadan

Riahi

Muhammad

et al. 2021

Journal of Viral Hepatitis

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Background Hepatitis B virus (HBV) has been considered a significant cause of human reproductive failure in different studies; however, there is a considerable disagreement on the true impacts of HBV on female reproduction. This study has evaluated the impact of HBV infection on pregnancy complications in natural pregnancy and also on pregnancy outcomes in women undergoing in vitro fertilization (IVF) treatment. Method We searched Embase, Web of Science, PubMed and Google Scholar databases to identify the potentially relevant studies. Summary odds ratio (OR) or standardized mean difference (SMD) with 95% confidence interval (CI) was applied to assess the relationship. Heterogeneity testing, sensitivity analysis and publication bias testing were also performed. Results A total of 42 studies concerning the effect of HBV infection on the natural and IVF pregnancy were included in this study. Our meta‐analysis results revealed that HBV infection had a positive correlation to gestational diabetes mellitus (GDM) [OR = 1.32 (1.17–1.48) (p < 0.01)] and preterm birth [OR = 1.26 (1.14–1.40) (p < 0.01)] in natural pregnancy; however, HBV infection was not significantly associated with decreased fertility rates among the patients who underwent IVF. Conclusion This study revealed a strong association of GDM and preterm birth with higher rates of HBV infection in pregnant women. Also, our results suggested that HBV infection in patients undergoing IVF may not negatively influence the pregnancy outcome. It may be rational to conclude that IVF might be rather a safe and effective method for HBV+ females who desire to have children.

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Section: Introductionmentioning

confidence: 99%

The effects of hepatitis B virus infection on natural and IVF pregnancy: A meta‐analysis study

Farsimadan

Riahi

Muhammad

et al. 2021

Journal of Viral Hepatitis

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“…Since the results of docking energy values are not a really precise indicator of inhibitory activity, we focused on the MD study of the best ligand bisfucotriphlorethol B with the Vpu protein. MD simulations are well‐established in silico tools for understanding the complex behavior of the ligand and the receptor at the molecular level [5, 34]. A low RMSD value after the equilibrium state (i.e., after 25 ns of simulation) for the MD simulation indicates a low fluctuation of ligand in reference to its primary position and verifies the low value of docking scores.…”

Section: Resultsmentioning

confidence: 99%

“…The particle‐mesh‐based Ewald pattern was utilized for summation of long‐range electrostatic forces. A cutoff radius range of 9.0 Å was set for computation of Columbic forces [34, 49, 50].…”

Section: Methodsmentioning

confidence: 99%

Phlorotannins as HIV Vpu inhibitors, an in silico virtual screening study of marine natural products

Langarizadeh

Abiri

Ghasemshirazi

et al. 2020

Biotech and App Biochem

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The importance of new effective treatment methodologies for human immunodeficiency virus (HIV) is undeniable for the medical society. Viral protein U (Vpu), one of the disparaged accessory proteins of HIV, is responsible for the dissemination of viral particles, and HIV mutants lacking Vpu protein have remarkably reduced pathogenicity. Here, we explored the marine natural products to find the leading structures which can potentially inhibit the activity of Vpu in silico. To fulfill this goal, we set up a virtual screening based on molecular docking to evaluate the binding capacity of different marine products to Vpu. For validation, we used molecular dynamics simulation and monitored the root mean square deviation value and binding interactions. The results were intriguing when we realized that the hit compounds (phlorotannins) had previously been identified as reverse transcriptase and HIV protease inhibitors. This research inaugurates a new road to combat HIV by multifaceted mode of action of these marine natural products without putting the normal cells in jeopardy (with their safe toxicological profile).

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“…Some single nucleotide polymorphisms (SNPs) in miRNA genes can impact their stability and affect the binding of miRNAs to their target genes, thus interfere with target gene recognition and expression (11). Many studies have investigated the association of SNPs with various female reproductive disorders (12)(13)(14), but a limited number of studies have investigated the effect of these SNPs in endometriosis. Therefore, in this study, we evaluated the prevalence and the association of three different miRNAs variants including, miR-27a rs895819A>G, miR-124-1 rs531564G>C, and miR-423 rs6505162A>C with endometriosis to help further understand the importance of these variants in reproductive disorders among females.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA Variants miR-27a rs895819 and miR-423 rs6505162, but not miR-124-1 rs531564, are Linked to Endometriosis and its Severity

et al. 2022

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Background: While different studies have investigated the association of SNPs with female reproductive disorders, a limited number of studies have investigated the effect of microRNAs variants in endometriosis. In this study, we evaluated the prevalence and the association of three different miRNAs variants including, miR-27a rs895819, miR-124-1 rs531564, and miR-423 rs6505162 with endometriosis to help further elucidate the importance of these variants in female reproductive disorders.Methods: A total number of 440 women (220 cases and 220 controls) were included. DNA was extracted and genotyping of the SNPs was carried out by PCR.Results: The results showed that rs895819 and rs6505162 had a significant association with endometriosis under the dominant, recessive, co-dominant, and allelic model, but rs531564 was not linked to endometriosis. Our results also imply a protective effect on endometriosis severity for AG genotype and G allele in rs895819 (p < 0.001), and also for AA and AC genotypes in rs6505162 with severity in endometriosis (p < 0.001). Moreover, Hardy–Weinberg equilibrium, haplotype frequency, and linkage disequilibrium between SNPs were performed.Conclusion: miR-27a rs895819 and miR-423 rs6505162, but not miR-124-1 rs531564, are linked to endometriosis.

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Association of FSHR missense mutations with female infertility, in silico investigation of their molecular significance and exploration of possible treatments using virtual screening and molecular dynamics

Cited by 14 publications

References 59 publications

The effects of hepatitis B virus infection on natural and IVF pregnancy: A meta‐analysis study

The effects of hepatitis B virus infection on natural and IVF pregnancy: A meta‐analysis study

Phlorotannins as HIV Vpu inhibitors, an in silico virtual screening study of marine natural products

MicroRNA Variants miR-27a rs895819 and miR-423 rs6505162, but not miR-124-1 rs531564, are Linked to Endometriosis and its Severity

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