Association of Functional Polymorphisms of the XRCC4 Gene with the Risk of Breast Cancer: A Meta-analysis

Polymorphisms in DNA Repair Genes and Risk of Glioma and Meningioma

“…Although previous studies explored the association between XRCC3 and risk of glioma have shown the polymorphisms in rs3212092, rs861530 and rs861539 of XRCC3 are associated with glioma (Kiuru et al, 2008;Custódio et al, 2012;Liu et al, 2012;Zhou et al, 2012). A recent study conducted in China has indicated the rs861539 is associated with glioma risk (Liu et al, 2012).…”

Investigation of the effects of single-nucleotide polymorphisms in DNA repair genes on the risk of glioma

“…However, several studies have investigated the association between rs1800067 and other cancers such as breast cancer, non-small cell lung cancer, bladder cancer, prostate cancer, and head and neck cancer (Chiu et al, 2008;Mandal et al, 2011;Zhou et al, 2012;Yin et al, 2012;Mittal et al, 2012). These studies suggested that individuals with the T allele genotype are more susceptible to various cancers, and this genotype might decrease the effectiveness of anticancer treatments.…”

Association between single nucleotide polymorphisms of X-ray repair cross-complementing protein 4 gene and development of pancreatic cancer

“…Numerous epidemiologic studies have reported that XRCC4 gene polymorphisms are associated with the risk of several types of cancers, such as colorectal cancer, acute lymphoblastic leukemia, breast cancer, glioma, hepatocellular carcinoma, non-small-cell lung cancer, esophageal cancer and prostate cancer (Bau et al, 2010;Chokkalingam et al, 2011;Zhou et al, 2012;He et al, 2013;Long et al, 2013;Zhao et al, 2013;Fan et al, 2013;Shao et al, 2014). Bau et al (2010) investigated the association between XRCC4 gene polymorphisms and the susceptibility to colorectal cancer, and suggested that XRCC4 rs6869366 polymorphism may contribute to the development of esophageal cancer and may be useful for early detection of colorectal cancer.…”