Association of GA genotype of SNP rs4680 in COMT gene with psoriasis

Соболев, В. В.; Sakaniya, L. R.; Tretiakov, Artemii; Кокаева, З.Г.; Наумова, Е. А.; Рудько, О.И.; Соболева, А. Г.; Danilin, I.; Korsunskaya, I. M.; Klimov, Eugene

doi:10.1007/s00403-019-01904-1

Cited by 11 publications

(9 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among genetic studies we retrieved, Mössner et al [ 50 ] did not find a significant contribution of the 5-HTTLPR polymorphism to Ps susceptibility and comorbidity of Ps with depressive symptoms. Differently, Sobolev et al [ 51 ], who investigated several genes encoding for enzymes involved in neurotransmitter metabolic pathways, evidenced that only a GA genotype of the COMT gene was significantly associated with Ps. Therefore, the authors excluded the 5-HT involvement and suggested a role for catecholamines and norepinephrine in particular.…”

Section: Discussionmentioning

confidence: 99%

“…Such findings do not support a major contribution of the 5-HTTLPR polymorphism to Ps susceptibility and depressive symptoms in psoriatic patients. Sobolev et al [51] investigated associations of Ps with a single nucleotide polymorphism (SNP) in different genes, such as several encoding enzymes involved in the biosynthetic and catabolic pathways of some neurotransmitters such as catechol-O-methyltransferase (COMT), dopamine beta-hydroxylase (DBH), cholecystokinin-A-receptor, and CCK-B-receptor. Among the studied genes, the authors found that only a GA genotype of the COMT gene was significantly associated with Ps (χ 2 = 19.163 [p = 1.3EÀ5], F (p) = 1.2EÀ5, OR 3.47 [CI 99% = 1.61-7.91]).…”

Section: Genetic Studiesmentioning

confidence: 99%

See 1 more Smart Citation

A systematic review on shared biological mechanisms of depression and anxiety in comorbidity with psoriasis, atopic dermatitis, and hidradenitis suppurativa

et al. 2021

View full text Add to dashboard Cite

Background Mental disorders in comorbidity with chronic skin diseases may worsen disease outcome and patients’ quality of life. We hypothesized the comorbidity of depression, anxiety syndromes, or symptoms as attributable to biological mechanisms that the combined diseases share. Methods We conducted a systematic review based on the Preferred Reporting Items for Systematic Review and Meta-Analysis statement searching into PubMed, PsycInfo, and Scopus databases. We examined the literature regarding the comorbidity of psoriasis (Ps), atopic dermatitis (AD), or hidradenitis suppurativa with depression and/or anxiety in adults ≥18 years and the hypothetical shared underlying biological mechanisms. Results Sixteen studies were analyzed, mostly regarding Ps and AD. Brain-derived neurotrophic factor/tropomyosin receptor kinase B signaling and nuclear factor kappa-light-chain-enhancer of activated B cells/p38 mitogen-activated protein kinase pathways arose as shared mechanisms in Ps animal models with depression- and/or anxiety-like behaviors. Activated microglia and neuroinflammatory responses emerged in AD depressive models. As to genetic studies, atopic-dermatitis patients with comorbid anxiety traits carried the short variant of serotonin transporter and a polymorphism of the human translocator protein gene. A GA genotype of catechol-O-methyltransferase gene was instead associated with Ps. Reduced natural killer cell activity, IL-4, serotonin serum levels, and increased plasma cortisol and IgE levels were hypothesized in comorbid depressive AD patients. In Ps patients with comorbid depression, high serum concentrations of IL-6 and IL-18, as well as IL-17A, were presumed to act as shared inflammatory mechanisms. Conclusions Further studies should investigate mental disorders and chronic skin diseases concurrently across patients’ life course and identify their temporal relation and biological correlates. Future research should also identify biological characteristics of individuals at high risk of the comorbid disorders and associated complications.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Genetic Studiesmentioning

confidence: 99%

A systematic review on shared biological mechanisms of depression and anxiety in comorbidity with psoriasis, atopic dermatitis, and hidradenitis suppurativa

et al. 2021

View full text Add to dashboard Cite

show abstract

“…[4][5][6] Huang et al 4 reported a frequency of 52% for a European cohort. The frequency reported by Sobolev et al 5 is 51.1% in patients with psoriasis and 48.2% in controls, and frequency of 47.95% in a European cohort was reported by Ghisari et al 6 In our cohort, the frequency of the DRD2 rs1799732 DEL allele was statistically similar to the one reported for the 1000 Genomes European cohort (6% vs. 8%, χ 2 =3.1, p=0.078). The test for the genotypes of variant rs1799732 was statistically similar to the genotype distribution for the 1000 Genomes dataset (χ 2 =3.85, p=0.15).…”

Section: Resultsmentioning

confidence: 99%

Exploring pharmacogenetic variation in a Bulgarian psychiatric cohort

Ivanov

Velinov²,

Kyosovksa³

et al. 2021

View full text Add to dashboard Cite

Introduction: Pharmacogenetics in psychiatry is currently gaining momentum. The efficiency of antipsychotic therapy is often limited by the lack of response and the presence of side effects. Pharmacogenetic variation is probably one of the causative factors for the observed interindividual differences in the response to and the side effects of antipsychotics, which could be addressed and whose negative effects could be avoided or mitigated. Aim: The present study aimed to conduct a comprehensive analysis of the frequency of DRD2 rs1799732, COMT rs4680, MC4R rs489693, and HTR2C rs3813929 in Bulgarian psychiatric patients. Materials and methods: The frequency of genotypes and the alleles of variants DRD2 rs1799732, COMT rs4680, MC4R rs489693, and HTR2C rs3813929 were studied in a cohort of 515 Bulgarian psychiatric patients using the polymerase chain reaction (PCR) method. Results: We found no significant difference between our cohort and the dataset of the 1000 Genomes Project. Moreover, we found that 433 out of 515 patients carried at least one, and 191 out of 515 carried at least two variants which, based on multiple scientific sources with consistent findings, could potentially alter the expected response rate, time to respond and/or risk of side effects to antipsychotic medications. Conclusions: Considering the consistent data about the frequency of these pharmacogenetic variants, testing these genetic variants may prove useful in clinical practice. Further studies regarding the clinical interpretation and frequency distribution in larger cohorts and different populations are warranted.

show abstract

“…Выявлены значимая ассоциация с риском развития псориаза генов семейства поздних ороговевших конвертов LCE3B/3C [11], которые участвуют в формировании эпидермальных клеток и кожного барьера и высоко представлены в псориатических поражениях, и гены NO-синтаз NOS1, NOS2 и NOS3 [12][13][14][15], которые влияют на поддержание воспалительного процесса в пораженной коже и являются регулятором роста и дифференцировки кератиноцитов. Совсем недавно обнаружена ассоциация генов [COMT (rs4680), DBH (rs141116007), CCKAR (rs1800857) и CCKBR (rs1805002)], отвечающих за психоэмоциональные расстройства, с псориазом [16][17][18][19][20]. Эти результаты впервые на генетическом уровне подтвердили, что в развитии заболевания в качестве факторов предрасположенности участвуют психические расстройства, а также подтверждены данные по корреляции дерматологических заболеваний с патологической тревожностью и стрессом [21].…”

Section: генетические маркерыunclassified

Basic genetic and biological markers of psoriasis

et al. 2021

View full text Add to dashboard Cite

Background. Psoriasis is a chronic inflammatory autoimmune disease characterized by an excessively aberrant hyperproliferation of keratinocytes. The pathogenesis of psoriasis is complex, and the exact mechanism, despite numerous studies, is still unclear. Complex genetic relationships play an important role in the pathogenesis of this skin disease. A large number of genes that are also associated with other diseases are involved in the development of psoriasis. The variety of comorbidities in patients with psoriasis often present challenges to the treatment for dermatosis. Understanding the role of certain genes in the pathogenesis of psoriasis will contribute the development of more effective targeted therapy aimed at blocking the corresponding inflammatory signaling pathways and molecules. Aim. To analyze and systematize the basic genetic and biological markers of psoriasis. Materials and methods. The study included research articles on the genetic analysis of psoriasis. The ResNet, PubMed and eLibrary databases were used. Results and discussion. Basic genetic and biological markers were identified by analysis of literature sources devoted to psoriasis. Attention is paid to the role and effects of single nucleotide polymorphisms, which make it possible to establish a clear association of a number of genes involved in the development of psoriasis. Genes with altered expression in the psoriatic process were considered separately. Conclusion. The identified biomarkers can be used in targeted biological therapy of psoriasis using biological modulators that block signaling.

show abstract

Association of GA genotype of SNP rs4680 in COMT gene with psoriasis

Cited by 11 publications

References 27 publications

A systematic review on shared biological mechanisms of depression and anxiety in comorbidity with psoriasis, atopic dermatitis, and hidradenitis suppurativa

A systematic review on shared biological mechanisms of depression and anxiety in comorbidity with psoriasis, atopic dermatitis, and hidradenitis suppurativa

Exploring pharmacogenetic variation in a Bulgarian psychiatric cohort

Basic genetic and biological markers of psoriasis

Contact Info

Product

Resources

About