Association of Genetic and Environmental Risks for Attention-Deficit/Hyperactivity Disorder With Hypomanic Symptoms in Youths

Hosang, Georgina M.; Lichtenstein, Paul; Ronald, Angelica; Lundström, Sebastian; Taylor, Mark J.

doi:10.1001/jamapsychiatry.2019.1949

Cited by 18 publications

(19 citation statements)

References 41 publications

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“…Together this evidence supports the hypothesis that common genetic variants acting additively play a role in the causes of ADHD 3 . In addition, twin, family, and molecular genetic studies suggest that these common variants may to some degree be shared with other conditions and traits, including autism and autistic traits 5,6,7,8,9,10 , tobacco and alcohol use 11,12 , and depressive and hypomanic symptoms 13,14,15 .…”

Section: Introductionmentioning

confidence: 99%

Systematic Review: How the Attention-Deficit/Hyperactivity Disorder Polygenic Risk Score Adds to Our Understanding of ADHD and Associated Traits

Ronald

Bode

Polderman

2021

Journal of the American Academy of Child & Adolescent Psych

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Introductionmentioning

confidence: 99%

Systematic Review: How the Attention-Deficit/Hyperactivity Disorder Polygenic Risk Score Adds to Our Understanding of ADHD and Associated Traits

Ronald

Bode

Polderman

2021

Journal of the American Academy of Child & Adolescent Psych

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“…We hypothesized that working memory and inhibition would be associated with psychotic experiences, given that executive function is one of the most commonly observed deficits among individuals with schizophrenia through various stages of the disease, 12 and that attention would be associated with depression, 13 BPD, 14 and hypomania. 15…”

Section: Introductionmentioning

confidence: 99%

Longitudinal Associations Between Cognitive Deficits in Childhood and Psychopathological Symptoms in Adolescence and Young Adulthood

et al. 2021

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IMPORTANCE Cognitive deficits are core features of mental disorders and are important in predicting long-term prognosis. However, it is still unknown whether individual patterns of cognitive deficits predate specific mental disorders.OBJECTIVE To investigate the specificity of the associations of attention, working memory, and inhibition in childhood with borderline personality disorder (BPD), psychosis, depression, and hypomania in adolescence and young adulthood.

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“…A case in point is a recently published genetic study on the association of genetic and environmental risks for attention deficit hyperactivity disorder (ADHD) with hypomanic symptoms in youth (Hosang et al 2019). The findings hinge on two questionnaires that were given to assess hypomania-the Child Mania Rating Scale-Short Form (Henry et al 2008) and the Mood Disorders Questionnaire (Wagner et al 2006).…”

Section: Origins Of the Controversymentioning

confidence: 99%

Pre-pubertal bipolar disorder: origins and current status of the controversy

Duffy

Carlson

Dubicka

et al. 2020

Int J Bipolar Disord

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Background: Evidence from epidemiological, clinical and high-risk studies has established that the peak period of risk for onset of bipolar disorder spans late adolescence and early adulthood. However, the proposal of the existence of a pre-pubertal form of bipolar disorder manifesting in early childhood created substantial debate. In this narrative review, the literature and contributing factors pertaining to the controversy surrounding the proposed pre-pubertal bipolar disorder subtype are discussed. The resolution of the debate and lessons learned are highlighted. Main body: In the mid 1990s US researchers proposed that chronic irritability and explosive temper in pre-pubertal children with pre-existing ADHD and/or other learning and developmental disorders might represent a variant of mania. A number of factors contributed to this proposal including severely ill children with no diagnostic home given changes in the ADHD DSM diagnostic criteria and over-reliance on symptoms and structured interviews rather than on a clinical assessment incorporating developmental history, social context and clinical course. Prospective studies of children at high familial risk did not support the proposed pre-pubertal bipolar phenotype; but rather provided convergent evidence that bipolar disorder onset in adolescence and early adulthood not uncommonly preceded by sleep and internalizing symptoms and most often debuting as depression in adolescence (after puberty). Epidemiological studies of population and hospital discharge data provided evidence that the pre-pubertal bipolar phenotype was largely a US driven phenomenon. Conclusions: Psychiatric diagnosis is particularly challenging given the current lack of objective biomarkers. However, validity and utility of clinical diagnoses can be strengthened if all available predictive information is used to formulate a diagnosis. As in other areas of medicine, critical information required to make a valid diagnosis includes developmental history, clinical course, family history and treatment response-weighed against the known trajectories of classical disorders. Moreover, given that psychiatric disorders are in evolution over childhood and adolescence and symptoms, in of themselves, are often non-specific, a thorough clinical assessment incorporating collateral history and psychosocial context is paramount. Such an approach might have avoided or at least brought a more timely resolution to the debate on pre-pubertal mania.

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Association of Genetic and Environmental Risks for Attention-Deficit/Hyperactivity Disorder With Hypomanic Symptoms in Youths

Cited by 18 publications

References 41 publications

Systematic Review: How the Attention-Deficit/Hyperactivity Disorder Polygenic Risk Score Adds to Our Understanding of ADHD and Associated Traits

Systematic Review: How the Attention-Deficit/Hyperactivity Disorder Polygenic Risk Score Adds to Our Understanding of ADHD and Associated Traits

Longitudinal Associations Between Cognitive Deficits in Childhood and Psychopathological Symptoms in Adolescence and Young Adulthood

Pre-pubertal bipolar disorder: origins and current status of the controversy

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