Association of genetic polymorphism of HLA-DRB1 antigens with the susceptibility to lepromatous leprosy

Escamilla-Tilch, Mónica; Torres‐Carrillo, Nora Magdalena; Ramos-Payán, Rosalío; Aguilar‐Medina, Maribel; Salazar, Ma Isabel; Fafutis‐Morris, Mary; Arenas‐Guzmán, Roberto; Estrada‐Parra, Sergio; Estrada-Garcı́a, Iris; Granados, Julio

doi:10.3892/br.2013.167

Cited by 4 publications

(5 citation statements)

References 26 publications

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“…For this purpose and taking into account that the majority of cases of leprosy in Mexico are MB [3, 15], we only considered the MB leprosy and control group for this analysis. The distribution of genotypic and allelic frequencies of IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene polymorphisms in patients with leprosy and healthy controls is shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…We investigated the possible association with leprosy in 144 Mexican Mestizo individuals (75 leprosy patients and 69 healthy controls) who were genotyped for the IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene polymorphisms. For this purpose and taking into account that the majority of cases of leprosy in Mexico are MB [ 3 , 15 ], we only considered the MB leprosy and control group for this analysis. The distribution of genotypic and allelic frequencies of IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene polymorphisms in patients with leprosy and healthy controls is shown in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

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Lack of Association of the PolymorphismsIL-17A(−197G/A) andIL-17F(+7488A/G) with Multibacillary Leprosy in Mexican Patients

Escamilla-Tilch

Estrada-Garcı́a

Granados

et al. 2014

International Journal of Genomics

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Background. Leprosy is a chronic infectious disease caused by the intracellular acid-fast bacilli Mycobacterium leprae; it has been determined that genetic factors of the host play an important role in the disease susceptibility. Thus, in this case-control study, we evaluated the possible association between the IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene SNPs and susceptibility to leprosy disease in Mexican population. Methods. Seventy-five leprosy patients and sixty-nine control subjects were included. Both SNPs were genotyped with the polymerase chain reaction-restriction fragment length polymorphism technique. Results. We found nonsignificant differences in genotype and allele frequencies related to IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene SNPs in MB as well as subclinical forms of leprosy disease versus healthy individuals. Conclusions. Since the sample size is not large enough, it is difficult to sustain an association of susceptibility to leprosy with genotypes or allele frequencies of IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780), suggesting that IL-17 polymorphisms have no significant role in the genetic susceptibility to development of this disease in the Mexican Mestizo population.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Lack of Association of the PolymorphismsIL-17A(−197G/A) andIL-17F(+7488A/G) with Multibacillary Leprosy in Mexican Patients

Escamilla-Tilch

Estrada-Garcı́a

Granados

et al. 2014

International Journal of Genomics

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“…Although leprosy is of infectious etiology, studies have demonstrated that a genetic component and its variability serve a crucial role in the establishment and progression of the disease (5,6). In previous reports, our group observed that human leukocyte antigen (HLA)-DRB1*01 and HLA-A*28 alleles were associated with susceptibility to leprosy, whereas HLA-DRB1*08 was associated with resistance, in a Mexican mestizo population (23,24). The rs2476601 polymorphism of PTPN22 has been associated with a negative regulatory function in T-cell signaling and with autoimmune diseases including type 1 diabetes (25), rheumatoid arthritis (26) and systemic lupus erythematosus (27), and several infectious diseases including tuberculosis and leprosy (15)(16)(17)(18).…”

Section: Discussionmentioning

confidence: 90%

Analysis of the rs2476601 polymorphism of PTPN22 in Mexican mestizo patients with leprosy

et al. 2019

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Leprosy, a human chronic granulomatous disease caused by Mycobacterium leprae (M. leprae), remains endemic in certain countries despite the use of multidrug therapy. Recently, several host genes modulating the immune responses to M. leprae infection have been suggested to influence the acquisition and clinical course of leprosy. Lymphoid protein tyrosine phosphatase, encoded by the protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene, serves a negative regulatory role in T cell activation. The non-synonymous single-nucleotide polymorphism (SNP) rs2476601 (1858C>T) has been associated with autoimmune diseases. Here, the present study investigated if rs2476601 polymorphism was associated with leprosy in a Mexican mestizo population. Genotyping was performed in patients with leprosy (n=189) and control subjects (n=231) from regions with higher incidence of leprosy. Genotypic (P=0.44) and allelic frequencies (P=0.45) of the rs2476601 polymorphism were similar between patients and controls; genotypic frequencies were 91 vs. 94% for CC and 9 vs. 6% for CT, and the TT genotype was absent in both groups. Allelic frequencies were 96 vs. 97% for C, and 4 vs. 3% for T. In the same way, the genotypic (P=0.46) and allelic frequencies (P=0.47) from MB patients and controls were similar. In conclusion, there was a lack of association of the PTPN22 rs2476601 polymorphism with the development of leprosy, which suggests that this SNP was not a genetic risk factor for leprosy in the Mexican mestizo population studied.

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“…() studied 92 patients and 315 controls from a Mexican‐American population, showing no significant differences for HLA‐A and ‐B serotypes among the groups. Recently, our group reported that HLA‐DRB1*01 is associated with susceptibility to LL and DL in a study performed with 52 patients and 99 controls from seven states of Mexico (Mónica Escamilla‐Tilch, ). Altogether, these results suggest that involvement of HLA antigens in susceptibility to leprosy in Mestizos may be influenced by the genetic diversity found in different resident populations of Mexico (Moreno‐Estrada et al., ).…”

Section: Discussionmentioning

confidence: 99%

HLA Alleles are Genetic Markers for Susceptibility and Resistance towards Leprosy in a Mexican Mestizo Population

Aguilar‐Medina

Escamilla-Tilch

Frías-Castro

et al. 2016

Annals of Human Genetics

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Despite the use of multidrug therapy, leprosy remains endemic in some countries. The association of several human leucocyte antigen (HLA) alleles and gene polymorphisms with leprosy has been demonstrated in many populations, but the major immune contributors associated to the spectrum of leprosy have not been defined yet. In this study, genotyping of HLA-A, -B, -DR, and -DQ alleles was performed in leprosy patients (n = 113) and control subjects (n = 117) from the region with the highest incidence for the disease in México. The odds of developing leprosy and lepromatous subtype were 2.12- and 2.74-fold higher in carriers of HLA-A*28, and 2.48- and 4.14-fold higher for leprosy and dimorphic subtype in carriers of DQB1*06. Interestingly, DQB1*07 was overrepresented in healthy individuals, compared to patients with leprosy (OR = 0.08) and the lepromatous subtype (OR = 0.06). These results suggest that HLA-A*28 is a marker for predisposition to leprosy and the lepromatous subtype and DQB1*06 to leprosy and the dimorphic subtype, while DQB1*07 might be a resistance marker in this Mestizo population.

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Association of genetic polymorphism of HLA-DRB1 antigens with the susceptibility to lepromatous leprosy

Cited by 4 publications

References 26 publications

Lack of Association of the PolymorphismsIL-17A(−197G/A) andIL-17F(+7488A/G) with Multibacillary Leprosy in Mexican Patients

Lack of Association of the PolymorphismsIL-17A(−197G/A) andIL-17F(+7488A/G) with Multibacillary Leprosy in Mexican Patients

Analysis of the rs2476601 polymorphism of PTPN22 in Mexican mestizo patients with leprosy

HLA Alleles are Genetic Markers for Susceptibility and Resistance towards Leprosy in a Mexican Mestizo Population

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