Lack of Association of the PolymorphismsIL-17A(−197G/A) andIL-17F(+7488A/G) with Multibacillary Leprosy in Mexican Patients

Abstract

Background. Leprosy is a chronic infectious disease caused by the intracellular acid-fast bacilli Mycobacterium leprae; it has been determined that genetic factors of the host play an important role in the disease susceptibility. Thus, in this case-control study, we evaluated the possible association between the IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene SNPs and susceptibility to leprosy disease in Mexican population. Methods. Seventy-five leprosy patients and sixty-nine control subjects were included. Both SNPs were genotyped with the polymerase chain reaction-restriction fragment length polymorphism technique. Results. We found nonsignificant differences in genotype and allele frequencies related to IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene SNPs in MB as well as subclinical forms of leprosy disease versus healthy individuals. Conclusions. Since the sample size is not large enough, it is difficult to sustain an association of susceptibility to leprosy with genotypes or allele frequencies of IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780), suggesting that IL-17 polymorphisms have no significant role in the genetic susceptibility to development of this disease in the Mexican Mestizo population.

IL8 and IL17A polymorphisms associated with multibacillary leprosy and reaction type 1 in a mixed population from southern Brazil

“…Consistent with our data, Escamilla‐Tilch et al. () found no association between the IL17A and IL17F polymorphisms and MB leprosy in Mexican patients. However, in a north Indian cohort, the IL17F T7488C was associated with susceptibility to leprosy (Chaitanya et al., ).…”

“…Furthermore, it has been reported that the IL-8 production can be stimulated by IL-17A and IL-17F (Lavocat, Maggi, Annunziato, & Miossec, 2016;Okamoto Yoshida et al, 2010), which are produced by Th17 cells and have been associated with leprosy and formation of a mycobacterial infection-induced granuloma in the lung (Escamilla-Tilch et al, 2014 744) genes contain polymorphisms associated with the secretion of IL-17 (Espinoza et al, 2011); these were also included.…”

Interleukin-17A in Egyptian leprosy patients: a clinical, genetic, and biochemical study

“…They found no association between IL-17A (rs2275913A/G) gene SNPs and leprosy. 20 Therefore, the present study confirmed the evidence of a lack of relationship between IL-17A (rs2275913A/G) gene polymorphism and leprosy susceptibility.…”

“…They found that genotype frequencies had non-significant differences in the overall leprosy patients and controls. 19 Also, Escamilla-Tilch et al 20 investigated 75 Mexican Mestizo leprosy patients versus 69 controls. Sixty-two patients were classified as LL, 2 as TL, 2 as BL, and 9 as dimorphic.…”

Correlation between interleukin gene polymorphisms and current prevalence and mortality rates due to novel coronavirus disease 2019 (COVID‐2019) in 23 countries

“…To test this hypothesis and to limit any confounding bias (latitude, etc. ), we focused on the countries whose IL‐6 gene polymorphisms at rs1800796 and rs1800795 loci, IL‐6R gene polymorphism at rs2228145 locus, IL‐10 gene polymorphism at rs1800896 and rs1800871 loci, IL‐17A gene polymorphism at rs2275913 and IL‐17F gene polymorphism at rs763780 loci were defined and the allele frequencies were reported in 54 studies 10–63 . We searched the literature for the interleukin gene polymorphisms determined in the populations of China, Japan, India, Spain, Mexico, Sweden, Turkey, Brazil, Russia, Poland, Italy, South Africa, Netherlands, Greece, Germany, UK, Iran, Finland, Czechia, Tunisia, Norway, Egypt, Croatia.…”