Association of Genetic Polymorphism of <i>Pre-MicroRNA-146a</i> rs2910164 and Serum High-Mobility Group Box 1 With Febrile Seizures in Egyptian Children

Issac, Marianne Samir M.; Girgis, Marian; Haroun, Mervat; Shalaby, Amal

doi:10.1177/0883073814550312

Cited by 12 publications

(7 citation statements)

References 32 publications

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“…Although previous reports support the hypothesis that miRNAs may contribute to the pathogenesis of epilepsy, studies on the role of microRNAs in the pathophysiology of FS are limited. 5,6,12,13,[17][18][19][20][21][22] Several pro-inflammatory cytokines increase during FS, and, as a consequence, their related miRNAs are also affected. 4,6 Omran et al 7 revealed a negative correlation between IL-1β and miRNA146a expression.…”

Section: Discussionmentioning

confidence: 99%

“…The genetic polymorphisms might play a role in this correlation. A study conducted by Issac et al 12 revealed that rs2910164 polymorphism in the pre-microRNA-146a gene might be accompanied by an upregulation of proinflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

“…11 The role of miRNAs in the pathophysiology of FS has rarely been investigated. 12,13 Thus, in the present study, we aimed to investigate miRNAs 146a, 155, 181 and 223 expressions in children with FS and compare these to levels in febrile controls.…”

mentioning

confidence: 99%

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Expression of MicroRNA 146a, 155, 181 and 223 in febrile seizure

Çarman¹,

Karal²,

Mert³

et al. 2021

Turk J Pediatr

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The pathophysiology of febrile seizure (FS) is not fully understood, and research results have revealed a complex interaction of inflammation, genetic tendency and cytokines. Tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β) and interleukin 6 (IL-6) are the main cytokines involved in the pathophysiology of FS. 1,2 MicroRNAs (miRNAs) are small non-coding RNAs, and their main target is messenger RNAs (mRNAs). More than two thousand miRNAs have been identified thus far, and more than half of these are expressed in the human brain. 3 Alteration in the expression levels of specific miRNAs has been suggested as a possible cause in the pathophysiology of different diseases, such as cancer, Parkinson disease and epilepsy. 3,4 miRNAs have emerged as potent regulators of inflammation. 4,5 For example, miRNA-146a is the first inflammation-associated miRNA.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Expression of MicroRNA 146a, 155, 181 and 223 in febrile seizure

Çarman¹,

Karal²,

Mert³

et al. 2021

Turk J Pediatr

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“…Kornblit et al postulated this relationship based on in silico modeling, while others demonstrated it in pneumonia and cancer [ 48 , 49 , 50 ]. Several polymorphisms in gene loci of microRNAs regulating HMGB1 expression were also identified [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Decreased Expression of the High Mobility Group Box 1 (HMGB1) Gene in Peripheral Blood in Patients with Mild or Moderate Clostridioides difficile Infection

et al. 2020

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Cytokines are mediators of inflammation induced in the course of Clostridioides difficile infection (CDI). High Mobility Group Box 1 (HMGB1) is a cytokine playing an important role in the pathogenesis of numerous inflammatory and autoimmune diseases. The aim of the study was to assess the HMGB1 gene expression in the course of CDI. We have performed a prospective case-control study- including 55 adult patients, among them 27 with CDI, who were hospitalized from October 2018 to February 2020 and 28 healthy volunteers. We assessed: a complete blood count with differential leukocyte count, blood creatinine, albumin, and C-reactive protein (CRP) levels. Then, the expression of the HMGB1 gene was evaluated using quantitative Real-Time PCR. Patients with CDI were found to have a significant increase in white blood cells (WBC), neutrophil count, and CRP levels, they also exhibited decreased levels of albumin compared with controls. The HMGB1 gene expression was significantly lower among patients with CDI compared with the control group and significantly, inversely correlated with CRP level in blood. In conclusion, we have observed a decreased expression of the HMGB1 gene in peripheral blood of patients with mild or moderate CDI, which hypothetically could reflect their diminished capability to fight the pathogen.

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“…The complex interactions between immune‐inflammatory processes, cytokine activation, and genetic factors play important roles in the development of FS 99,100 . The levels of blood HMGB1 and IL‐1β in children with FS after 30 min of seizure attacks were significantly higher than those with fever only, and these two inflammatory indicators were correlated with each other 101–103 . HMGB1 contributes to the onset of FS and plays an important role in the occurrence of secondary epilepsy associated with the prolongation of FS, 104 and the occurrence of adult epilepsy is related to the recurrence of FS in childhood 105 .…”

Section: Role Of Hmgb1 In Pediatric Diseasesmentioning

confidence: 98%

The performance of the alarmin HMGB1 in pediatric diseases: From lab to clinic

Peng

et al. 2020

Immunity Inflam & Disease

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Introduction The ubiquitously expressed nonhistone nuclear protein high‐mobility group box protein 1 (HMGB1) has different functions related to posttranslational modifications and cellular localization. In the nucleus, HMGB1 modulates gene transcription, replication and DNA repair as well as determines chromosomal architecture. When the post‐transcriptional modified HMGB1 is released into the extracellular space, it triggers several physiological and pathological responses and initiates innate immunity through interacting with its reciprocal receptors (i.e., TLR4/2 and RAGE). The effect of HMGB1‐mediated inflammatory activation on different systems has received increasing attention. HMGB1 is now considered to be an alarmin and participates in multiple inflammation‐related diseases. In addition, HMGB1 also affects the occurrence and progression of tumors. However, most studies involving HMGB1 have been focused on adults or mature animals. Due to differences in disease characteristics between children and adults, it is necessary to clarify the role of HMGB1 in pediatric diseases. Methods and Results Through systematic database retrieval, this review aimed to first elaborate the characteristics of HMGB1 under physiological and pathological conditions and then discuss the clinical significance of HMGB1 in the pediatric diseases according to different systems. Conclusions HMGB1 plays an important role in a variety of pediatric diseases and may be used as a diagnostic biomarker and therapeutic target for new strategies for the prevention and treatment of pediatric diseases.

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Association of Genetic Polymorphism of Pre-MicroRNA-146a rs2910164 and Serum High-Mobility Group Box 1 With Febrile Seizures in Egyptian Children

Cited by 12 publications

References 32 publications

Expression of MicroRNA 146a, 155, 181 and 223 in febrile seizure

Expression of MicroRNA 146a, 155, 181 and 223 in febrile seizure

Decreased Expression of the High Mobility Group Box 1 (HMGB1) Gene in Peripheral Blood in Patients with Mild or Moderate Clostridioides difficile Infection

The performance of the alarmin HMGB1 in pediatric diseases: From lab to clinic

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