Association of genetic polymorphisms of IL1β -511 C>T, IL1RN VNTR 86 bp, IL6 -174 G>C, IL10 -819 C>T and TNFα -308 G>A, involved in symptomatic patients with dengue in Brazil

Abstract

In summary, the findings of this study in a Brazilian population point out the importance of studies of combinations of polymorphisms in the development of dengue, which can increase the risk of dengue infection and its severity.

The severity of the pathogen-induced acute sickness response is affected by polymorphisms in genes of the NLRP3 inflammasome pathway

“…NLRP3 responses are triggered by the recognition of viral RNA, bacterial products or sub-particles, as well as by tissue injury factors such as release of extracellular ATP, or the efflux of K + (Murphy et al, 2017). Interestingly, single nucleotide polymorphisms (SNPs) in different components, or regulators, of this pathway have been associated with heightened innate immune responses in different infective conditions, including dengue (Cansanção et al, 2016), hepatitis C (Estfanous et al, 2019), and tuberculosis (Abate et al, 2019), but also auto-immune conditions as rheumatoid arthritis (Jahid et al, 2018;Addobbati et al, 2018). In this study functional SNPs in the NLRP3 pathway were examined in relation to the severity and duration of the acute sickness response (ASR) to several different infectious diseases.…”